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    Actl6b actin-like 6B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288563, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Actl6bprovided by RGD
    Official Full Name
    actin-like 6Bprovided by RGD
    Primary source
    RGD:1307763
    See related
    EnsemblRapid:ENSRNOG00000001408 AllianceGenome:RGD:1307763
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Actl6
    Summary
    Predicted to enable chromatin binding activity. Involved in spinal cord development. Located in nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to human ACTL6B (actin like 6B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 112.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24761660..24778193, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19124887..19141419, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22194595..22211107, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene motile sperm domain containing 3 Neighboring gene transferrin receptor 2 Neighboring gene small nuclear ribonucleoprotein Sm D1-like Neighboring gene G protein subunit beta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons. Bell S, et al. Am J Hum Genet, 2019 May 2. PMID 31031012, Free PMC Article
    2. miR-9*- and miR-124a-Mediated switching of chromatin remodelling complexes is altered in rat spina bifida aperta. Wei X, et al. Neurochem Res, 2013 Aug. PMID 23677776
    3. Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues. Harata M, et al. Biosci Biotechnol Biochem, 1999 May. PMID 10380635
    4. Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex. Kuroda Y, et al. Biochem Biophys Res Commun, 2002 Nov 29. PMID 12437990
    5. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. Shain AH, et al. PLoS One, 2013. PMID 23355908, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spinal cord development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nBAF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nBAF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin-like protein 6B
    Names
    BAF53B
    BRG1-associated factor 53B
    actin-like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105917.1 → NP_001099387.2  actin-like protein 6B

      See identical proteins and their annotated locations for NP_001099387.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/Swiss-Prot
      A6J021, P86173
      UniProtKB/TrEMBL
      A0A0G2JW70
      Related
      ENSRNOP00000069766.2, ENSRNOT00000087817.3
      Conserved Domains (1) summary
      pfam00022
      Location:11 → 426
      Actin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      24761660..24778193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249120.4 → XP_006249182.1  actin-like protein 6B isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW70, A0A8L2UHA2
      Related
      ENSRNOP00000001910.6, ENSRNOT00000001910.9
      Conserved Domains (1) summary
      pfam00022
      Location:11 → 444
      Actin

    2. XM_039089206.2 → XP_038945134.1  actin-like protein 6B isoform X2

      UniProtKB/TrEMBL
      A6J022
      Conserved Domains (1) summary
      pfam00022
      Location:1 → 290
      Actin

    3. XM_039089208.2 → XP_038945136.1  actin-like protein 6B isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:2 → 245
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. XM_063271148.1 → XP_063127218.1  actin-like protein 6B isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P86173.2 GenPept UniProtKB/Swiss-Prot:P86173

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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