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Conserved domains on  [gi|1958668186|ref|XP_038945136|]
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actin-like protein 6B isoform X3 [Rattus norvegicus]

Protein Classification

acetate and sugar kinases/Hsc70/actin family protein( domain architecture ID 99298)

acetate and sugar kinases/Hsc70/actin (ASKHA) family protein catalyzes phosphoryl transfer from ATP to their respective substrates

CATH:  3.30.420.40
Gene Ontology:  GO:0000166
PubMed:  8800467|7781919
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 2-236 3.00e-151

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd13395:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 413  Bit Score: 427.37  E-value: 3.00e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186   2 MAMSYSIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKeKLPQVSKSWHNYMCNEVIQDFQAS 81
Cdd:cd13395   175 YVLQKAIVRSPLGGDFLTDQLLKLLESKNIEIIPRYMIKSKEPVEGGAPAKYTKK-DLPNTTSSYHRYMVRRVLQDFKES 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  82 VLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKG-----LSGNTMLGVGHVVTTSIGMCDIDI 156
Cdd:cd13395   254 VCQVSDSPFDESEAASIPTVSYELPDGYNIEFGAERFKIPELLFDPSLVKGipappSEGNELLGLPQLVYTSIGSCDVDI 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 157 RPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGG 236
Cdd:cd13395   334 RPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLKLKILASGNTVERRFSSWIGGSILASLGSFQQMWISKQEYEEHG 413
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 2-236 3.00e-151

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 427.37  E-value: 3.00e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186   2 MAMSYSIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKeKLPQVSKSWHNYMCNEVIQDFQAS 81
Cdd:cd13395   175 YVLQKAIVRSPLGGDFLTDQLLKLLESKNIEIIPRYMIKSKEPVEGGAPAKYTKK-DLPNTTSSYHRYMVRRVLQDFKES 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  82 VLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKG-----LSGNTMLGVGHVVTTSIGMCDIDI 156
Cdd:cd13395   254 VCQVSDSPFDESEAASIPTVSYELPDGYNIEFGAERFKIPELLFDPSLVKGipappSEGNELLGLPQLVYTSIGSCDVDI 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 157 RPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGG 236
Cdd:cd13395   334 RPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLKLKILASGNTVERRFSSWIGGSILASLGSFQQMWISKQEYEEHG 413
Actin pfam00022
Actin;
2-245 2.49e-116

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 338.51  E-value: 2.49e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186   2 MAMSYSIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPvreGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQAS 81
Cdd:pfam00022 162 YVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKKP---GDPAPAVTKRELPDTTYSYKTYQERRVLEEIKES 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  82 VLQVSDSPY-DEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSG----NTMLGVGHVVTTSIGMCDIDI 156
Cdd:pfam00022 239 VCYVSDDPFgDETTSSSIPTRVYELPDGSTIILGAERFRVPEILFNPSLIGSESElpppQTAVGIPELIVDAINACDVDL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 157 RPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGG 236
Cdd:pfam00022 319 RPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGNTVERRYSAWIGGSILASLGTFQQMWVSKQEYEEHG 398


                  ....*....
gi 1958668186 237 KQCVERKCP 245
Cdd:pfam00022 399 ASVVERKCK 407
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 2-244 7.54e-78

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 239.08  E-value: 7.54e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186    2 MAMSYSIVKSPLAGDFISMQCRELFQEmaiDIIPPYMIAAKEPVREGappnwkkKEKLPQVSKSWHNYMCNeviqdfqas 81
Cdd:smart00268 164 YVLPHAIKRIDIAGRDITDYLKELLSE---RGYQFNSSAEFEIVREI-------KEKLCYVAEDFEKEMKL--------- 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186   82 vlqvsdspYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVkglsGNTMLGVGHVVTTSIGMCDIDIRPGLY 161
Cdd:smart00268 225 --------ARESSESSKLEKTYELPDGNTIKVGNERFRIPEILFSPELI----GLEQKGIHELVYESIQKCDIDVRKDLY 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  162 GSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIAsnsTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVE 241
Cdd:smart00268 293 ENIVLSGGSTLIPGFGERLEKELKQLAPKKLKVKVIA---PPERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVE 369


                   ...
gi 1958668186  242 RKC 244
Cdd:smart00268 370 RKC 372
PTZ00004 PTZ00004
actin-2; Provisional
 101-244 4.39e-45

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 154.93  E-value: 4.39e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 101 VHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTM-LGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDR 179
Cdd:PTZ00004  240 ESYELPDGTIITVGSERFRCPEALFQPS----LIGKEEpPGIHELTFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPER 315

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958668186 180 LNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 244
Cdd:PTZ00004  316 LTKELTTLAPSTMKIKVVAP---PERKYSVWIGGSILSSLPTFQQMWVTKEEYDESGPSIVHRKC 377
COG5277 COG5277
Actin-related protein [Cytoskeleton];
73-234 4.45e-19

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 85.23  E-value: 4.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  73 EVIQDFQASVLQVSDSPYDE-QVAAQMPT---VHYEMPNGYNT----DYGAERLRIPEGLFDP----------------- 127
Cdd:COG5277   228 YVVRVVKEALGLVPRDLAKAiQKAASNPDsfeAKVRLPNPTVEielgNYAWERFLIGEILFNPnhegfesyiqqgrlrie 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 128 -SNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLL---QGFTD-------RLNRELSQKTPpSMRLKL 196
Cdd:COG5277   308 dAVIGDVVLYGEMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLEDvavdsvtRVQIELSELAP-ELKVNV 386

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958668186 197 IASNstmERKFSPWIGGSILASLGTFQQMW--ISKQEYEE 234
Cdd:COG5277   387 RLVS---DPQYSVWKGAIIYGYALPFSVKWswITKEGWYF 423
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
 175-244 6.19e-15

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 69.24  E-value: 6.19e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 175 GFTDRLNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 244
Cdd:NF040575   66 GFYEKLKKSITEKAPKGALIGMTLD---PKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRKC 132
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 2-236 3.00e-151

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 427.37  E-value: 3.00e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186   2 MAMSYSIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKeKLPQVSKSWHNYMCNEVIQDFQAS 81
Cdd:cd13395   175 YVLQKAIVRSPLGGDFLTDQLLKLLESKNIEIIPRYMIKSKEPVEGGAPAKYTKK-DLPNTTSSYHRYMVRRVLQDFKES 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  82 VLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKG-----LSGNTMLGVGHVVTTSIGMCDIDI 156
Cdd:cd13395   254 VCQVSDSPFDESEAASIPTVSYELPDGYNIEFGAERFKIPELLFDPSLVKGipappSEGNELLGLPQLVYTSIGSCDVDI 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 157 RPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGG 236
Cdd:cd13395   334 RPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLKLKILASGNTVERRFSSWIGGSILASLGSFQQMWISKQEYEEHG 413
Actin pfam00022
Actin;
2-245 2.49e-116

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 338.51  E-value: 2.49e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186   2 MAMSYSIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPvreGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQAS 81
Cdd:pfam00022 162 YVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKKP---GDPAPAVTKRELPDTTYSYKTYQERRVLEEIKES 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  82 VLQVSDSPY-DEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSG----NTMLGVGHVVTTSIGMCDIDI 156
Cdd:pfam00022 239 VCYVSDDPFgDETTSSSIPTRVYELPDGSTIILGAERFRVPEILFNPSLIGSESElpppQTAVGIPELIVDAINACDVDL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 157 RPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGG 236
Cdd:pfam00022 319 RPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGNTVERRYSAWIGGSILASLGTFQQMWVSKQEYEEHG 398


                  ....*....
gi 1958668186 237 KQCVERKCP 245
Cdd:pfam00022 399 ASVVERKCK 407
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 2-244 7.54e-78

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 239.08  E-value: 7.54e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186    2 MAMSYSIVKSPLAGDFISMQCRELFQEmaiDIIPPYMIAAKEPVREGappnwkkKEKLPQVSKSWHNYMCNeviqdfqas 81
Cdd:smart00268 164 YVLPHAIKRIDIAGRDITDYLKELLSE---RGYQFNSSAEFEIVREI-------KEKLCYVAEDFEKEMKL--------- 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186   82 vlqvsdspYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVkglsGNTMLGVGHVVTTSIGMCDIDIRPGLY 161
Cdd:smart00268 225 --------ARESSESSKLEKTYELPDGNTIKVGNERFRIPEILFSPELI----GLEQKGIHELVYESIQKCDIDVRKDLY 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  162 GSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIAsnsTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVE 241
Cdd:smart00268 293 ENIVLSGGSTLIPGFGERLEKELKQLAPKKLKVKVIA---PPERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVE 369


                   ...
gi 1958668186  242 RKC 244
Cdd:smart00268 370 RKC 372
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
 3-236 1.80e-50

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 168.52  E-value: 1.80e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186   3 AMSYSIVKSPLAGDFISMQCRELFQEMAIDIIPPymiAAKEPVREgappnwkKKEKLPQVSkswhnymcneviQDFQAsV 82
Cdd:cd13397   165 ALPHAVQRLDLAGRDLTEYLMKLLKERGHSFTTT---AEREIVRD-------IKEKLCYVA------------LDYEE-E 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  83 LQVSDSPYDEqvaaqmptvHYEMPNGYNTDYGAERLRIPEGLFDPSNVkglsGNTMLGVGHVVTTSIGMCDIDIRPGLYG 162
Cdd:cd13397   222 LKKKSEELEK---------EYTLPDGQVIKIGSERFRCPEALFRPSLI----GREAPGIHKLVYNSIMKCDIDIRKDLYS 288

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668186 163 SVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWISKQEYEEGG 236
Cdd:cd13397   289 NIVLSGGSTMFPGLPERLQKELEALAPSSTKVKVIAPP---ERKYSVWIGGSILASLSTFKSMWITRAEYDEFG 359
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
 90-240 6.93e-49

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 164.46  E-value: 6.93e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  90 YDE--QVAAQMPTVH--YEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVI 165
Cdd:cd10224   218 FEQemQTAASSSSLEksYELPDGQVITIGNERFRCPEALFQPS----FLGMEAAGIHETTYNSIMKCDVDIRKDLYANIV 293

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958668186 166 VTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCV 240
Cdd:cd10224   294 LSGGTTMFPGIADRMQKEITALAPSTMKIKIVAPP---ERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIV 365
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
 100-244 1.12e-46

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 158.86  E-value: 1.12e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 100 TVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDR 179
Cdd:cd10216   233 KAQYTLPDGSTIEIGPERFRAPEILFNPE----LIGLEYPGVHEVLVDSIQKSDLDLRKTLYSNIVLSGGSTLFKGFGDR 308

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958668186 180 LNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 244
Cdd:cd10216   309 LLSEVKKLAPKDVKIRISAPP---ERLYSTWIGGSILASLSTFKKMWVSKKEYEEDGARILHRKT 370
PTZ00004 PTZ00004
actin-2; Provisional
 101-244 4.39e-45

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 154.93  E-value: 4.39e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 101 VHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTM-LGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDR 179
Cdd:PTZ00004  240 ESYELPDGTIITVGSERFRCPEALFQPS----LIGKEEpPGIHELTFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPER 315

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958668186 180 LNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 244
Cdd:PTZ00004  316 LTKELTTLAPSTMKIKVVAP---PERKYSVWIGGSILSSLPTFQQMWVTKEEYDESGPSIVHRKC 377
PTZ00281 PTZ00281
actin; Provisional
 73-244 8.34e-43

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 149.08  E-value: 8.34e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  73 EVIQDFQASVLQVS-DSPYDEQVAAQMPTVH--YEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSI 149
Cdd:PTZ00281  208 EIVRDIKEKLAYVAlDFEAEMQTAASSSALEksYELPDGQVITIGNERFRCPEALFQPS----FLGMESAGIHETTYNSI 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 150 GMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWISK 229
Cdd:PTZ00281  284 MKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPP---ERKYSVWIGGSILASLSTFQQMWISK 360

                         170
                  ....*....|....*
gi 1958668186 230 QEYEEGGKQCVERKC 244
Cdd:PTZ00281  361 EEYDESGPSIVHRKC 375
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
 137-236 5.09e-41

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 141.09  E-value: 5.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 137 TMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSIL 216
Cdd:cd10169   162 KLCGLHELIYDSIMKCDIDLRKELYSNIVLSGGTTLFPGFAERLQKELSKLAPSSVKVKVIAP---PERKYSAWIGGSIL 238

                          90       100
                  ....*....|....*....|
gi 1958668186 217 ASLGTFQQMWISKQEYEEGG 236
Cdd:cd10169   239 ASLSTFQQMWITKEEYEEHG 258
PTZ00466 PTZ00466
actin-like protein; Provisional
 73-243 4.35e-40

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 142.00  E-value: 4.35e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  73 EVIQDFQASVLQVSDSPYDEQVAAQ--MPTVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSIG 150
Cdd:PTZ00466  213 EVVKNMKENCCYVSFNMNKEKNSSEkaLTTLPYILPDGSQILIGSERYRAPEVLFNPS----ILGLEYLGLSELIVTSIT 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 151 MCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWISKQ 230
Cdd:PTZ00466  289 RADMDLRRTLYSHIVLSGGTTMFHGFGDRLLNEIRKFAPKDITIRISAPP---ERKFSTFIGGSILASLATFKKIWISKQ 365

                         170
                  ....*....|...
gi 1958668186 231 EYEEGGKQCVERK 243
Cdd:PTZ00466  366 EFDEYGSVILHRK 378
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
 86-244 4.68e-39

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 138.71  E-value: 4.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  86 SDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVI 165
Cdd:cd10214   218 LDFEEEMGLPPQEYTVDYELPDGHLITIGKERFRCPEMLFNPS----LIGSKQPGLHTLTMNSLNKCDANLKKDLAKNIL 293

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958668186 166 VTGGNTLLQGFTDRLNRELSQKTPPSMRLkliaSNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 244
Cdd:cd10214   294 LCGGSTMFDGFPDRFQKELSKLCPNDNPI----VAASPERKYSVWTGGSILASLKSFQQLWVRRREYEERGPFVIYRKC 368
PTZ00452 PTZ00452
actin; Provisional
 90-244 4.22e-27

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 107.15  E-value: 4.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  90 YDEQVAAQMPtvhYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGG 169
Cdd:PTZ00452  230 YKESNSQDSP---YKLPDGNILTIKSQKFRCSEILFQPK----LIGLEVAGIHHLAYSSIKKCDLDLRQELCRNIVLSGG 302

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958668186 170 NTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 244
Cdd:PTZ00452  303 TTLFPGIANRLSNELTNLVPSQLKIQVAAPP---DRRFSAWIGGSIQCTLSTQQPQWIKRQEYDEQGPSIVHRKC 374
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
 116-236 2.59e-25

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 102.24  E-value: 2.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 116 ERLRIPEGLFDPSNVkglsGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLK 195
Cdd:cd10210   276 ERFTVPELLFHPSDI----GIQQAGIAEAIVQSINACPEELQPLLYANIVLTGGNALFPGFRERLEAELRSLAPDDYDVN 351

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958668186 196 LIASNSTMErkfSPWIGGSILASLGTFQQMWISKQEYEEGG 236
Cdd:cd10210   352 VTLPEDPIT---YAWEGGSLLAQSPEFEELAVTRAEYEEHG 389
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
 90-242 1.48e-19

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 86.46  E-value: 1.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  90 YD---EQVAAQMPTVH---YEMPNGYNTDYGAERLRIPEGLFDPS--NVKGLsgntmlGVGHVVTTSIGMCDIDIRPGLY 161
Cdd:cd10220   218 YDielEQKLALETTVLvesYTLPDGRVIKVGGERFEAPEALFQPHliDVEGP------GIAELLFNTIQAADIDTRPELY 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 162 GSVIVTGGNTLLQGFTDRLNRELSQ-------KTPPSmRLK--LIASNSTMERKFSPWIGGSILASLGTFQ-QMWISKQE 231
Cdd:cd10220   292 KHIVLSGGSTMYPGLPSRLEKEIKQlylervlKGDTE-RLSkfKIRIEDPPRRKHMVFLGGAVLADIMKDKdEFWITRQE 370

                         170
                  ....*....|.
gi 1958668186 232 YEEGGKQCVER 242
Cdd:cd10220   371 YEEQGVRVLDK 381
COG5277 COG5277
Actin-related protein [Cytoskeleton];
73-234 4.45e-19

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 85.23  E-value: 4.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  73 EVIQDFQASVLQVSDSPYDE-QVAAQMPT---VHYEMPNGYNT----DYGAERLRIPEGLFDP----------------- 127
Cdd:COG5277   228 YVVRVVKEALGLVPRDLAKAiQKAASNPDsfeAKVRLPNPTVEielgNYAWERFLIGEILFNPnhegfesyiqqgrlrie 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 128 -SNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLL---QGFTD-------RLNRELSQKTPpSMRLKL 196
Cdd:COG5277   308 dAVIGDVVLYGEMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLEDvavdsvtRVQIELSELAP-ELKVNV 386

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958668186 197 IASNstmERKFSPWIGGSILASLGTFQQMW--ISKQEYEE 234
Cdd:COG5277   387 RLVS---DPQYSVWKGAIIYGYALPFSVKWswITKEGWYF 423
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
 7-236 8.89e-19

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 84.40  E-value: 8.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186   7 SIVKSPLAGDFISmqcrELFQEMAIDiippymiaakepvREGAPPNWKKKEkLPQVSKSWHNYMCNEVIQDFQAsvlqvs 86
Cdd:PTZ00280  186 SIKHIPLAGRDIT----NFIQQMLRE-------------RGEPIPAEDILL-LAQRIKEKYCYVAPDIAKEFEK------ 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  87 dspYDEQVAAQMPTVHYEMP---NGYNTDYGAERLRIPEGLFDPsnvKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGS 163
Cdd:PTZ00280  242 ---YDSDPKNHFKKYTAVNSvtkKPYTVDVGYERFLGPEMFFHP---EIFSSEWTTPLPEVVDDAIQSCPIDCRRPLYKN 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 164 VIVTGGNTLLQGFTDRLNRELSQKT----------------PPSMRLKLIASNstMERkFSPWIGGSILASLGTFQQMWI 227
Cdd:PTZ00280  316 IVLSGGSTMFKGFDKRLQRDVRKRVdrrlkkaeelsggklkPIPIDVNVVSHP--RQR-YAVWYGGSMLASSPEFEKVCH 392


                  ....*....
gi 1958668186 228 SKQEYEEGG 236
Cdd:PTZ00280  393 TKAEYDEYG 401
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
 87-240 2.78e-17

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 79.74  E-value: 2.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  87 DSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIV 166
Cdd:cd10209   201 DEEAYEKKVLTCSPETYTLPDGRVISVGKERYCVGEALFRPS----ILGIEEYGIVEQLVRAVSTSPSENRRQLLENIVL 276

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958668186 167 TGGNTLLQGFTDRLNRELSQKTPPSMRLKLIA-----SNSTMErkFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCV 240
Cdd:cd10209   277 CGGTSSVPGLEARLQKEIRLLSSPSSRPALVKppeymPENTLR--YSAWIGGAILAKVVFPQNQHVTKADYDETGPSVV 353
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
 109-236 8.49e-16

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 75.68  E-value: 8.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 109 YNTDYGAERLRIPEGLFDPsnvKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKT 188
Cdd:cd10221   261 YTVDVGYERFLAPEIFFNP---EIASSDFTTPLPEVVDQVIQSCPIDTRRGLYKNIVLSGGSTMFKDFGRRLQRDVKRIV 337

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668186 189 ppSMRLKLIASNST----------------MERkFSPWIGGSILASLGTFQQMWISKQEYEEGG 236
Cdd:cd10221   338 --DARLKASEELSGgklkpkpidvnvishpMQR-YAVWFGGSMLASTPEFYTVCHTKAEYEEYG 398
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
 175-244 6.19e-15

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 69.24  E-value: 6.19e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 175 GFTDRLNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 244
Cdd:NF040575   66 GFYEKLKKSITEKAPKGALIGMTLD---PKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRKC 132
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
 114-236 1.49e-13

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 68.87  E-value: 1.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 114 GAERLRIPEGLFDPSNVKGLSGNTMLGVGHVVTTSigmCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMr 193
Cdd:cd10208   212 GKERFRACEPLFKPSSLRVDLLIAAIAGALVLNAS---DEPDKRPALWENIIIVGGGSRIRGLKEALLSELQQFHLISE- 287

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668186 194 lKLIASNSTMERKF-----------------SPWIGGSILASLgTF----QQMWISKQEYEEGG 236
Cdd:cd10208   288 -TSASPQQPRIIRLakipdyfpewkksgyeeAAFLGASIVAKL-VFndpsSKHYISKVDYNEKG 349
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
 140-236 7.48e-12

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 64.13  E-value: 7.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 140 GVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLI-ASNSTmerkFSPWIGGSILAS 218
Cdd:cd10211   245 GLVETIEFVLKRYPAEQQDRLVQNVFLTGGNALFPGLKERLEKELRAIRPFGSPFNVVrAKDPV----LDAWRGAAKWAL 320

                          90
                  ....*....|....*...
gi 1958668186 219 LGTFQQMWISKQEYEEGG 236
Cdd:cd10211   321 DSTFEKVWITKQEYEEKG 338
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 145-236 1.06e-11

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 63.80  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 145 VTTSIGMC-DIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSM----RLKLIASNSTMERKFSPWIGGSILASL 219
Cdd:cd10206   344 IVQSILSCaSDELKRKMYSSILLVGGGAKIPGLAEALEDRLLIKIPSLFeaveTVEVLPPPKDMDPSLLAWKGGAVLACL 423

                          90
                  ....*....|....*..
gi 1958668186 220 GTFQQMWISKQEYEEGG 236
Cdd:cd10206   424 DSAQELWITRKEWQRLG 440
ASKHA_NBD_Arp10 cd10207
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; ...
 73-234 7.60e-10

nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.


Pssm-ID: 466813 [Multi-domain]  Cd Length: 375  Bit Score: 58.03  E-value: 7.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  73 EVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYN-TDY---GAERLRIPEGLFDPSN-VKGLSGNTMLGVGHVVTT 147
Cdd:cd10207   191 EVLEDIKVRACFVTSLERGKTLQSATEEGSTEEPSPPPpVDYpldGEKILIVPGSIRESAEeLLFEGDNEEKSLPTLILD 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 148 SIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELS---QKTPPSMRLKLIASNS-TMERKFSP----WIGGSILASL 219
Cdd:cd10207   271 SLLKCPIDVRKQLAENIVVIGGTSMLPGFKHRLLEELRallRKPKYFEELAPKTFRFhTPPSVFKPnylaWLGGSIFGAL 350

                         170
                  ....*....|....*
gi 1958668186 220 GTFQQMWISKQEYEE 234
Cdd:cd10207   351 ESILGRSLSREAYLQ 365
ASKHA_NBD_AtArp8-like cd13396
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and ...
 90-232 2.67e-09

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and similar proteins; Arabidopsis thaliana ARP8, also called F-box protein ARP8, is an F-Box protein localized to the nucleolus. It is ubiquitously expressed in all organs and cell types and has a cell cycle-dependent subcellular pattern of distribution: it is localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.


Pssm-ID: 466847  Cd Length: 332  Bit Score: 56.40  E-value: 2.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186  90 YDEQVAAQMPTVHyEMPNGYNTDYGAERLRIPEGLFDPsnvkGLSGNTMLGVGHVVTTSIGMCDIDIRPG---LYGSVIV 166
Cdd:cd13396   188 YEAELAKDTQASC-EVAGEGWFTLSNERFKTGEILFQP----GLGGMRAMGLHQAVALCMDHCALVHSQGddgWFKTIVL 262

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668186 167 TGGNTLLQGFTDRLNRELSQKTPPSMrLKLIASNSTMERKFSPWIGGSILASLGTFQQMW-ISKQEY 232
Cdd:cd13396   263 SGGSACLPGLSERLERELRKLLPKSL-SEGIRIIPPPLGPDSAWQGAKLISNLSNFPDGWcITKKQF 328
ASKHA_NBD_ScArp7-like cd10212
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and ...
 140-233 6.36e-08

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; Saccharomyces cerevisiae Arp7, also called actin-like protein 7, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp7 forms a stable heterodimer with Arp9 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466818 [Multi-domain]  Cd Length: 424  Bit Score: 52.41  E-value: 6.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668186 140 GVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTpPSMRLKLIASNSTMERKFSPWIGGSILASL 219
Cdd:cd10212   326 GLGPLMAKSVKKAPEQVYSLLLTNVIITGSTSLIEGMEQRIIKELSIRF-PQYKLTTFANQVMMDRKIQGWLGALTMANL 404

                          90
                  ....*....|....*
gi 1958668186 220 GTFQ-QMWISKQEYE 233
Cdd:cd10212   405 PSWSlGKWYSKEDYE 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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