U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    FABP4 fatty acid binding protein 4, adipocyte [ Bos taurus (domestic cattle) ]

    Gene ID: 281759, updated on 4-Oct-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    FABP4
    Gene description
    fatty acid binding protein 4, adipocyte
    See related
    BGD:BT10868; Ensembl:ENSBTAG00000037526
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FABP4 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (44676559..44680947, complement)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene peripheral myelin protein 2 Neighboring gene fatty acid binding protein 9 Neighboring gene fatty acid binding protein 12 Neighboring gene uncharacterized LOC132342209

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Adenovirus-mediated interference of FABP4 regulates mRNA expression of ADIPOQ, LEP and LEPR in bovine adipocytes. Wei S, et al. Genet Mol Res, 2013 Feb 27. PMID 23315880
    2. Mammary derived growth inhibitor is not a distinct protein but a mix of heart-type and adipocyte-type fatty acid-binding protein. Specht B, et al. J Biol Chem, 1996 Aug 16. PMID 8702709
    3. The bovine fatty acid binding protein 4 gene is significantly associated with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses. Michal JJ, et al. Anim Genet, 2006 Aug. PMID 16879357
    4. Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle. Cho S, et al. BMB Rep, 2008 Jan 31. PMID 18304447
    5. Effects of FABP4 variation on milk fatty-acid composition for dairy cattle grazed on pasture in late lactation. Li Y, et al. J Dairy Res, 2020 Feb. PMID 32000870

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of FABP4 variation on milk fatty-acid composition for dairy cattle grazed on pasture in late lactation.
      Title: Effects of FABP4 variation on milk fatty-acid composition for dairy cattle grazed on pasture in late lactation.
    2. Studied SNPs in cattle Fatty Acid Binding Protein 4 (FABP4) in several cattle breeds and evaluated possible associations with regards to meat quality and fat content of the meat.
      Title: Genetic Variation in FABP4 and Evaluation of Its Effects on Beef Cattle Fat Content.
    3. Overexpressed FABP4 of different genotypes in bovine intramuscular preadipocytes and studied the intracellular localization of FABP4 and the expression levels of lipid metabolism-related genes among different genotypes.
      Title: Subcellular Localization and Polymorphism of Bovine FABP4 in Bovine Intramuscular Adipocytes.
    4. These results provide an important basis for further understanding the regulation of bovine FABP4.
      Title: Tissue expression analysis, cloning, and characterization of the 5'-regulatory region of the bovine fatty acid binding protein 4 gene.
    5. This suggest that FABP4 affects milk yield and milk protein content, both economically important traits, and that further study of this gene is warranted.
      Title: Variation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows.
    6. Data show that overexpression of cattle adipocyte fatty acid-binding protein (A-FABP)gene promoted fat deposition in the skeletal muscle of transgenic mice.
      Title: Overexpression of the A-FABP gene facilitates intermuscular fat deposition in transgenic mice.
    7. FABP4 gene frequency and SNP genotypes in Holstein-Friesian cows and its relationship with protein and fat content in milk
      Title: FABP3, FABP4 and ANXA9 SNP genotypes in relation to breeding values for milk production traits in Polish Holstein-Friesian cows.
    8. polymorphisms can be used to select for milk with lower concentrations of saturated fatty acids and higher concentrations of unsaturated fatty acids
      Title: Association of polymorphisms in solute carrier family 27, isoform A6 (SLC27A6) and fatty acid-binding protein-3 and fatty acid-binding protein-4 (FABP3 and FABP4) with fatty acid composition of bovine milk.
    9. The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
      Title: Effect of DNA polymorphisms related to fatty acid composition in adipose tissue of Holstein cattle.
    10. The results confirm the lack of an association found by many other studies and suggest that these SNPs are not influential on the divergent intramuscular fat levels in the crossbred population tested.
      Title: Association analysis of single nucleotide polymorphisms in DGAT1, TG and FABP4 genes and intramuscular fat in crossbred Bos taurus cattle.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    fatty acid-binding protein, adipocyte
    Names
    A-FABP
    AFABP
    ALBP
    adipocyte lipid-binding protein
    adipocyte-type fatty acid-binding protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174314.2 → NP_776739.1  fatty acid-binding protein, adipocyte

      See identical proteins and their annotated locations for NP_776739.1

      Status: PROVISIONAL

      Source sequence(s)
      X89244
      UniProtKB/Swiss-Prot
      P48035
      UniProtKB/TrEMBL
      A0AA95Z2M9
      Related
      ENSBTAP00000000079.3, ENSBTAT00000000079.5
      Conserved Domains (1) summary
      pfam00061
      Location:6 → 132
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      44676559..44680947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48035.2 GenPept UniProtKB/Swiss-Prot:P48035

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials