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    ZNF524 zinc finger protein 524 [ Homo sapiens (human) ]

    Gene ID: 147807, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF524provided by HGNC
    Official Full Name
    zinc finger protein 524provided by HGNC
    Primary source
    HGNC:HGNC:28322
    See related
    Ensembl:ENSG00000171443 AllianceGenome:HGNC:28322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 6.3), spleen (RPKM 5.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF524 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55599574..55603138)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58695510..58699073)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56111654..56114504)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11043 Neighboring gene Sharpr-MPRA regulatory region 13032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11045 Neighboring gene FLT3 interacting zinc finger 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56110254-56111128 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56111129-56112002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56113981-56114531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56115635-56116186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56116187-56116738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11048 Neighboring gene zinc finger protein 865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15098 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56135913-56136412 Neighboring gene zinc finger protein 784

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study of chronic periodontitis in a general German population. Teumer A, et al. J Clin Periodontol, 2013 Nov. PMID 24024966
    2. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Oliviero G, et al. Sci Rep, 2015 Dec 21. PMID 26687479, Free PMC Article
    3. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. Oliviero G, et al. Mol Cell Proteomics, 2016 Nov. PMID 27634302, Free PMC Article
    4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
    5. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC23143

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 524

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153219.4 → NP_694951.1  zinc finger protein 524

      See identical proteins and their annotated locations for NP_694951.1

      Status: VALIDATED

      Source sequence(s)
      AC008735, BC014666, BC067748, HY097571
      Consensus CDS
      CCDS12929.1
      UniProtKB/Swiss-Prot
      Q6NW31, Q96C55, Q96IL7
      Related
      ENSP00000301073.2, ENST00000301073.4
      Conserved Domains (3) summary
      PHA00733
      Location:169 → 221
      PHA00733; hypothetical protein
      COG5048
      Location:113 → 177
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55599574..55603138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526487.3 → XP_011524789.1  zinc finger protein 524 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:219 → 283
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:250 → 270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:234 → 259
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58695510..58699073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319881.1 → XP_054175856.1  zinc finger protein 524 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96C55.1 GenPept UniProtKB/Swiss-Prot:Q96C55

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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