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Conserved domains on  [gi|768006681|ref|XP_011524789|]
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zinc finger protein 524 isoform X1 [Homo sapiens]

Protein Classification

COG5048 and PHA00733 domain-containing protein( domain architecture ID 11472679)

COG5048 and PHA00733 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-283 2.61e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 2.61e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768006681 219 PHFCPVCLRAFPYLSDLERH--SISHS--ELKPHQCKV--CGKTFKRSSHLRRHCNIHAGLRPFRCPLCPR 283
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHlrSVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
PHA00733 super family cl26169
hypothetical protein
 275-327 6.14e-03

hypothetical protein


The actual alignment was detected with superfamily member PHA00733:

Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 6.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768006681 275 PFRCPLCPRRFREAGELAHHHRVhsGERPYQCPICRLRFTEANTLRRHAKRKH 327
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKH 123
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-283 2.61e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 2.61e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768006681 219 PHFCPVCLRAFPYLSDLERH--SISHS--ELKPHQCKV--CGKTFKRSSHLRRHCNIHAGLRPFRCPLCPR 283
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHlrSVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
zf-H2C2_2 pfam13465
Zinc-finger double domain;
234-259 1.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 768006681  234 DLERHSISHSELKPHQCKVCGKTFKR 259
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
248-270 2.91e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 2.91e-03
                           10        20
                   ....*....|....*....|...
gi 768006681   248 HQCKVCGKTFKRSSHLRRHCNIH 270
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 275-327 6.14e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 6.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768006681 275 PFRCPLCPRRFREAGELAHHHRVhsGERPYQCPICRLRFTEANTLRRHAKRKH 327
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKH 123
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 276-298 7.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.23e-03
                          10        20
                  ....*....|....*....|...
gi 768006681  276 FRCPLCPRRFREAGELAHHHRVH 298
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-283 2.61e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 2.61e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768006681 219 PHFCPVCLRAFPYLSDLERH--SISHS--ELKPHQCKV--CGKTFKRSSHLRRHCNIHAGLRPFRCPLCPR 283
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHlrSVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
zf-H2C2_2 pfam13465
Zinc-finger double domain;
234-259 1.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 768006681  234 DLERHSISHSELKPHQCKVCGKTFKR 259
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 248-270 3.17e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.17e-04
                          10        20
                  ....*....|....*....|...
gi 768006681  248 HQCKVCGKTFKRSSHLRRHCNIH 270
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-352 8.39e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 8.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006681 220 HFCPVCLRAFPYLSDLERHSISHS-ELKPHQCKVCGKTFKRSSHLRRH--CNIH--AGLRPFRCP--LCPRRFREAGELA 292
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKgFSLPIKSKQCNISFSRSSPLTRHlrSVNHsgESLKPFSCPysLCGKLFSRNDALK 340

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768006681 293 HHHRVHSGERPYQCPICRL--RFTEANTLRRHA---KRKHPEAMGVPLCAPDPGSEPPWDEEGIP 352
Cdd:COG5048  341 RHILLHTSISPAKEKLLNSssKFSPLLNNEPPQslqQYKDLKNDKKSETLSNSCIRNFKRDSNLS 405
zf-H2C2_2 pfam13465
Zinc-finger double domain;
262-285 9.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 9.14e-04
                          10        20
                  ....*....|....*....|....
gi 768006681  262 HLRRHCNIHAGLRPFRCPLCPRRF 285
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-270 2.05e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 2.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768006681 217 KAPHFCPVCLRAFPYLSDLERHSISHSELKPHQCKV--CGKTFKRSSHLRRHCNIH 270
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTH 86
ZnF_C2H2 smart00355
zinc finger;
248-270 2.91e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 2.91e-03
                           10        20
                   ....*....|....*....|...
gi 768006681   248 HQCKVCGKTFKRSSHLRRHCNIH 270
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 275-327 6.14e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 6.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768006681 275 PFRCPLCPRRFREAGELAHHHRVhsGERPYQCPICRLRFTEANTLRRHAKRKH 327
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKH 123
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 276-298 7.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.23e-03
                          10        20
                  ....*....|....*....|...
gi 768006681  276 FRCPLCPRRFREAGELAHHHRVH 298
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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