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    Gripap1 GRIP1 associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116493, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gripap1provided by RGD
    Official Full Name
    GRIP1 associated protein 1provided by RGD
    Primary source
    RGD:621249
    See related
    EnsemblRapid:ENSRNOG00000009071 AllianceGenome:RGD:621249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Grasp1
    Summary
    Enables guanyl-nucleotide exchange factor activity and ionotropic glutamate receptor binding activity. Involved in negative regulation of receptor clustering; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane; and regulation of recycling endosome localization within postsynapse. Located in dendrite; neuronal cell body; and presynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic early endosome membrane. Orthologous to human GRIPAP1 (GRIP1 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 105.2), Adrenal (RPKM 78.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gripap1 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17350817..17380626, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14678896..14708747, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15523929..15553702, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene OTU deubiquitinase 5 Neighboring gene solute carrier family 25 member 39, pseudogene 6 Neighboring gene potassium voltage-gated channel subfamily D member 1 Neighboring gene transcription factor binding to IGHM enhancer 3 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons. Mele M, et al. FASEB J, 2021 Aug. PMID 34245609
    2. Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. Hoogenraad CC, et al. PLoS Biol, 2010 Jan 19. PMID 20098723, Free PMC Article
    3. GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. Ye B, et al. Neuron, 2000 Jun. PMID 10896157
    4. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons.
      Title: GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of modification of synaptic structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of recycling endosome localization within postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of recycling endosome localization within postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of recycling endosome localization within postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of postsynaptic early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of postsynaptic early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GRIP1-associated protein 1
    Names
    GRASP-1
    GRIP-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053807.2 → NP_446259.1  GRIP1-associated protein 1

      See identical proteins and their annotated locations for NP_446259.1

      Status: VALIDATED

      Source sequence(s)
      BQ780554, JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q9JHZ3, Q9JHZ4
      UniProtKB/TrEMBL
      A0A8I5ZRM3, A6KP79
      Related
      ENSRNOP00000012646.7, ENSRNOT00000012646.9
      Conserved Domains (2) summary
      COG1196
      Location:193 → 496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:8 → 337
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17350817..17380626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279751.1 → XP_063135821.1  GRIP1-associated protein 1 isoform X21

    2. XM_063279749.1 → XP_063135819.1  GRIP1-associated protein 1 isoform X19

    3. XM_063279744.1 → XP_063135814.1  GRIP1-associated protein 1 isoform X10

    4. XM_063279750.1 → XP_063135820.1  GRIP1-associated protein 1 isoform X20

    5. XM_063279747.1 → XP_063135817.1  GRIP1-associated protein 1 isoform X14

    6. XM_063279740.1 → XP_063135810.1  GRIP1-associated protein 1 isoform X4

    7. XM_063279738.1 → XP_063135808.1  GRIP1-associated protein 1 isoform X2

    8. XM_063279746.1 → XP_063135816.1  GRIP1-associated protein 1 isoform X12

    9. XM_063279742.1 → XP_063135812.1  GRIP1-associated protein 1 isoform X7

    10. XM_063279739.1 → XP_063135809.1  GRIP1-associated protein 1 isoform X3

    11. XM_063279741.1 → XP_063135811.1  GRIP1-associated protein 1 isoform X5

    12. XM_063279743.1 → XP_063135813.1  GRIP1-associated protein 1 isoform X9

    13. XM_063279737.1 → XP_063135807.1  GRIP1-associated protein 1 isoform X1

    14. XM_063279754.1 → XP_063135824.1  GRIP1-associated protein 1 isoform X24

    15. XM_063279753.1 → XP_063135823.1  GRIP1-associated protein 1 isoform X23

      Related
      ENSRNOP00000081274.1, ENSRNOT00000104859.2

    16. XM_063279745.1 → XP_063135815.1  GRIP1-associated protein 1 isoform X11

    17. XM_063279748.1 → XP_063135818.1  GRIP1-associated protein 1 isoform X16

    18. XM_063279752.1 → XP_063135822.1  GRIP1-associated protein 1 isoform X22

    19. XM_039099405.2 → XP_038955333.1  GRIP1-associated protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZRM3
      Conserved Domains (2) summary
      PTZ00121
      Location:28 → 575
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:193 → 465
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    20. XM_039099401.2 → XP_038955329.1  GRIP1-associated protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZRM3
      Conserved Domains (2) summary
      PTZ00121
      Location:196 → 717
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:3 → 381
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    21. XM_039099404.2 → XP_038955332.1  GRIP1-associated protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZRM3, A6KP78
      Related
      ENSRNOP00000085406.1, ENSRNOT00000111277.2
      Conserved Domains (1) summary
      COG1196
      Location:148 → 451
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    22. XM_039099399.2 → XP_038955327.1  GRIP1-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZRM3
      Conserved Domains (2) summary
      COG1196
      Location:184 → 487
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:9 → 622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    23. XM_039099403.2 → XP_038955331.1  GRIP1-associated protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZRM3
      Conserved Domains (1) summary
      COG1196
      Location:157 → 460
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    24. XM_039099400.2 → XP_038955328.1  GRIP1-associated protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZRM3
      Related
      ENSRNOP00000097700.2, ENSRNOT00000102832.2
      Conserved Domains (1) summary
      TIGR02168
      Location:244 → 617
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHZ4.1 GenPept UniProtKB/Swiss-Prot:Q9JHZ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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