ANP32B acidic nuclear phosphoprotein 32 family member B [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANP32Bprovided by HGNC
Official Full Name: acidic nuclear phosphoprotein 32 family member Bprovided by HGNC
Primary source: HGNC:HGNC:16677
See related: Ensembl:ENSG00000136938 MIM:619823; AllianceGenome:HGNC:16677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APRIL; SSP29; PHAPI2
Summary: Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bone marrow (RPKM 88.8), lymph node (RPKM 73.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q22.33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (97983341..98015943)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (110155281..110187884)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (100745623..100778225)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.
Title: Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.
ANP32B inhibition suppresses the growth of prostate cancer cells by regulating c-Myc signaling.
Title: ANP32B inhibition suppresses the growth of prostate cancer cells by regulating c-Myc signaling.
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A.
Title: The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A.
ANP32B promotes lung cancer progression by regulating VDAC1.
Title: ANP32B promotes lung cancer progression by regulating VDAC1.
KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity.
Title: KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity.
A natural variant in ANP32B impairs influenza virus replication in human cells.
Title: A natural variant in ANP32B impairs influenza virus replication in human cells.
Interaction of host cellular factor ANP32B with matrix proteins of different paramyxoviruses.
Title: Interaction of host cellular factor ANP32B with matrix proteins of different paramyxoviruses.
ANP32A and ANP32B mediate the export of unspliced or partially spliced viral mRNA via interactions with Rev and CRM1.
Title: ANP32A and ANP32B are key factors in the Rev-dependent CRM1 pathway for nuclear export of HIV-1 unspliced mRNA.
ANP32A and ANP32B from different species are powerful factors in the maintenance of viral polymerase activity. Human ANP32A and ANP32B contribute equally to support human influenza viral RNA replication.
Title: Fundamental Contribution and Host Range Determination of ANP32A and ANP32B in Influenza A Virus Polymerase Activity.
Human ANP32A and ANP32B homologues both support function of human-adapted influenza polymerase but do not support efficient activity of avian IAV polymerase which requires avian ANP32A.
Title: Species specific differences in use of ANP32 proteins by influenza A virus.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	The interaction of Rev with ANP32B is decreased by the presence of RRE	PubMed
	rev	HIV-1 Rev interacting protein, acidic (leucine-rich) nuclear phosphoprotein 32 family, member B (ANP32B), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70770 (e-PCR)
- UniSTS:47794

PMC311040P1 (e-PCR)
- UniSTS:272846

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in roof of mouth development	IEA Inferred from Electronic Annotation more info
involved_in vasculature development	IEA Inferred from Electronic Annotation more info
involved_in ventricular system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
colocalizes_with nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acidic leucine-rich nuclear phosphoprotein 32 family member B

Names: acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic protein rich in leucines; putative HLA-DR-associated protein I-2; silver-stainable protein SSP29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.