Pcdhb18 protocadherin beta 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcdhb18provided by MGI
Official Full Name: protocadherin beta 18provided by MGI
Primary source: MGI:MGI:2136756
See related: Ensembl:ENSMUSG00000048347 AllianceGenome:MGI:2136756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pcdhb9; PcdhbR
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to be active in plasma membrane. Orthologous to human PCDHB10 (protocadherin beta 10) and PCDHB9 (protocadherin beta 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 18 B3; 18 19.5 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (37622524..37627558)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (37489465..37494503)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protocadherin beta-18

Names: PCDH-beta-18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053143.3 → NP_444373.1 protocadherin beta-18 precursor

See identical proteins and their annotated locations for NP_444373.1

Status: VALIDATED

Source sequence(s)

AC020967

Consensus CDS

CCDS29184.1

UniProtKB/Swiss-Prot

Q91Y02

UniProtKB/TrEMBL

Q3USI6

Related

ENSMUSP00000052113.3, ENSMUST00000055949.4

Conserved Domains (3) summary

cd11304
Location:247 → 343

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:32 → 112

Cadherin_2; Cadherin-like

pfam16492
Location:688 → 771

Cadherin_C_2; Cadherin cytoplasmic C-terminal