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SLC16A7 solute carrier family 16 member 7 [ Homo sapiens (human) ]

Gene ID: 9194, updated on 11-Apr-2024

Summary

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Official Symbol
SLC16A7provided by HGNC
Official Full Name
solute carrier family 16 member 7provided by HGNC
Primary source
HGNC:HGNC:10928
See related
Ensembl:ENSG00000118596 MIM:603654; AllianceGenome:HGNC:10928
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT2
Summary
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Broad expression in fat (RPKM 11.7), heart (RPKM 9.2) and 22 other tissues See more
Orthologs
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Genomic context

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See SLC16A7 in Genome Data Viewer
Location:
12q14.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (59596029..59789841)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (59572554..59766418)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (59989810..60183622)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6575 Neighboring gene RNA, U4 small nuclear 20, pseudogene Neighboring gene polyadenylate-binding protein 4-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:60265054-60265568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:60265569-60266081 Neighboring gene uncharacterized LOC124903070

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function. Medel V, et al. Proc Natl Acad Sci U S A, 2022 Aug 16. PMID 35939682, Free PMC Article
  2. Cooperative transport mechanism of human monocarboxylate transporter 2. Zhang B, et al. Nat Commun, 2020 May 15. PMID 32415067, Free PMC Article
  3. Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer. Pertega-Gomes N, et al. Oncotarget, 2015 Aug 28. PMID 26035357, Free PMC Article
  4. Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer. Valença I, et al. J Cell Mol Med, 2015 Apr. PMID 25639644, Free PMC Article
  5. The genetic variation in monocarboxylic acid transporter 2 (MCT2) has functional and clinical relevance with male infertility. Lee J, et al. Asian J Androl, 2014 Sep-Oct. PMID 24799634, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
    Title: Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
  2. Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function.
    Title: Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function.
  3. Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.
    Title: Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.
  4. Cooperative transport mechanism of human monocarboxylate transporter 2.
    Title: Cooperative transport mechanism of human monocarboxylate transporter 2.
  5. the present study reports that the combination of tumour stroma percentage and tumour cell expression of cytoplasmic MCT-2 or nuclear LDH-5 is associated with poor prognosis.
    Title: The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer.
  6. MCT2 dictates the mode of action of N-oxalylglycine (NOG) by determining its intracellular concentration
    Title: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.
  7. Adipocytes promote malignant growth of breast tumors with MCT2 expression via beta-hydroxybutyrate.
    Title: Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate.
  8. SLC16A7 (MCT2) epigenetic regulation results in protein over-expression, affecting signalling and cellular phenotypes in prostate cancer
    Title: Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer.
  9. Data suggest that monocarboxylate transporter 2 (MCT2) at peroxisomes is related to an increase in beta-oxidation levels which may be crucial for malignant transformation.
    Title: Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer.
  10. This study identified that CGPs was found to significantly correlate with the differential expression and methylation of genes encoding solute carrier family 16, member 7.
    Title: Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lactate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lactate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyruvate secondary active transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables pyruvate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lactate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane lactate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 2
Names
solute carrier family 16 (monocarboxylate transporter), member 7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270622.2 → NP_001257551.1  monocarboxylate transporter 2

    See identical proteins and their annotated locations for NP_001257551.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC079905, AC119793, AF058056, BC007463, BC030693, DR000391
    Consensus CDS
    CCDS8961.1
    UniProtKB/Swiss-Prot
    O60669, Q8NEM3, Q9UPB3
    UniProtKB/TrEMBL
    F8W0N3
    Related
    ENSP00000449547.1, ENST00000552432.5
    Conserved Domains (1) summary
    TIGR00892
    Location:15 → 458
    2A0113; monocarboxylate transporter 1

  2. NM_001270623.2 → NP_001257552.1  monocarboxylate transporter 2

    See identical proteins and their annotated locations for NP_001257552.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC079905, AC119793, AF049608, AF058056, BC007463, BC030693, DR000391
    Consensus CDS
    CCDS8961.1
    UniProtKB/Swiss-Prot
    O60669, Q8NEM3, Q9UPB3
    UniProtKB/TrEMBL
    F8W0N3
    Related
    ENSP00000448071.1, ENST00000547379.6
    Conserved Domains (1) summary
    TIGR00892
    Location:15 → 458
    2A0113; monocarboxylate transporter 1

  3. NM_004731.5 → NP_004722.2  monocarboxylate transporter 2

    See identical proteins and their annotated locations for NP_004722.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC079905, AF058056, BC030693
    Consensus CDS
    CCDS8961.1
    UniProtKB/Swiss-Prot
    O60669, Q8NEM3, Q9UPB3
    UniProtKB/TrEMBL
    F8W0N3
    Related
    ENSP00000261187.4, ENST00000261187.8
    Conserved Domains (1) summary
    TIGR00892
    Location:15 → 458
    2A0113; monocarboxylate transporter 1

RNA

  1. NR_073055.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079905, AF058056, AK301725, BC030693

  2. NR_073056.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079905, AF058056, AK310281, BC030693

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    59596029..59789841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538989.3 → XP_011537291.1  monocarboxylate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011537291.1

    UniProtKB/TrEMBL
    F8W0N3
    Conserved Domains (2) summary
    cd06174
    Location:20 → 449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15 → 484
    2A0113; monocarboxylate transporter 1

  2. XM_011538992.3 → XP_011537294.1  monocarboxylate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011537294.1

    UniProtKB/TrEMBL
    F8W0N3
    Conserved Domains (2) summary
    cd06174
    Location:20 → 449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15 → 484
    2A0113; monocarboxylate transporter 1

  3. XM_024449276.2 → XP_024305044.1  monocarboxylate transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    O60669, Q8NEM3, Q9UPB3
    UniProtKB/TrEMBL
    F8W0N3
    Conserved Domains (1) summary
    TIGR00892
    Location:15 → 458
    2A0113; monocarboxylate transporter 1

  4. XM_011538991.3 → XP_011537293.1  monocarboxylate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011537293.1

    UniProtKB/TrEMBL
    F8W0N3
    Conserved Domains (2) summary
    cd06174
    Location:20 → 449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15 → 484
    2A0113; monocarboxylate transporter 1

  5. XM_005269231.4 → XP_005269288.1  monocarboxylate transporter 2 isoform X2

    See identical proteins and their annotated locations for XP_005269288.1

    UniProtKB/Swiss-Prot
    O60669, Q8NEM3, Q9UPB3
    UniProtKB/TrEMBL
    F8W0N3
    Related
    ENSP00000446722.1, ENST00000548610.5
    Conserved Domains (1) summary
    TIGR00892
    Location:15 → 458
    2A0113; monocarboxylate transporter 1

  6. XM_011538990.4 → XP_011537292.1  monocarboxylate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011537292.1

    UniProtKB/TrEMBL
    F8W0N3
    Conserved Domains (2) summary
    cd06174
    Location:20 → 449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15 → 484
    2A0113; monocarboxylate transporter 1

  7. XM_017020226.3 → XP_016875715.1  monocarboxylate transporter 2 isoform X3

    UniProtKB/TrEMBL
    B4DWX9
    Conserved Domains (1) summary
    cd06174
    Location:1 → 324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  8. XM_011538995.3 → XP_011537297.1  monocarboxylate transporter 2 isoform X3

    See identical proteins and their annotated locations for XP_011537297.1

    UniProtKB/TrEMBL
    B4DWX9
    Conserved Domains (1) summary
    cd06174
    Location:1 → 324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  9. XM_047429885.1 → XP_047285841.1  monocarboxylate transporter 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    59572554..59766418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373834.1 → XP_054229809.1  monocarboxylate transporter 2 isoform X1

  2. XM_054373837.1 → XP_054229812.1  monocarboxylate transporter 2 isoform X1

  3. XM_054373838.1 → XP_054229813.1  monocarboxylate transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    O60669, Q8NEM3, Q9UPB3

  4. XM_054373839.1 → XP_054229814.1  monocarboxylate transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    O60669, Q8NEM3, Q9UPB3

  5. XM_054373836.1 → XP_054229811.1  monocarboxylate transporter 2 isoform X1

  6. XM_054373835.1 → XP_054229810.1  monocarboxylate transporter 2 isoform X1

  7. XM_054373840.1 → XP_054229815.1  monocarboxylate transporter 2 isoform X3

  8. XM_054373841.1 → XP_054229816.1  monocarboxylate transporter 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60669.2 GenPept UniProtKB/Swiss-Prot:O60669

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