|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
15-484 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 755.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 15 DGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGrifesfliftslriqcsftqs 94
Cdd:TIGR00892 13 DGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGG--------------------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 95 gsclgPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANG 174
Cdd:TIGR00892 72 -----PISSILVNRFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 175 LAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKikTKKS 254
Cdd:TIGR00892 147 LAMAGSPVFLSTLAPLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKEGLPPDGSTKKL--SKKS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 255 TWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKY 334
Cdd:TIGR00892 225 TAEKINRFLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKW 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 335 IRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLL 414
Cdd:TIGR00892 305 IRPHVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLI 384
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975940 415 GPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPL-SKSKHSE 484
Cdd:TIGR00892 385 GPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYINYRLLAKEQKAALEREGARDKKDAeGDSRESE 455
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
19-451 |
0e+00 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 630.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGrifesfliftslriqcsftqsgscl 98
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGG------------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 gPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17427 56 -PISSILVNKYGSRPVVIAGGLLCSLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMA 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17427 135 GSPVFLSTLAPLNQFLFNQFGWRGSFLILGGLLLNCCVAGSLMRPLGP-------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPR 338
Cdd:cd17427 183 --------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPR 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 IQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL 418
Cdd:cd17427 255 IQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPL 334
|
410 420 430
....*....|....*....|....*....|...
gi 767975940 419 AGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGN 451
Cdd:cd17427 335 GGKLVDVTGNYKYMYFVCGAIVIVASIWLFIGN 367
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
19-450 |
0e+00 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 513.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGrifesfliftslriqcsftqsgscl 98
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGG------------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 gPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17426 56 -PISSILVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMA 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17426 135 GSPVFLSTLAPLNQWFFDIFGWRGSFLILGGLLLNCCVAGSLMRPIGP-------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPR 338
Cdd:cd17426 183 -KPFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPR 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 IQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL 418
Cdd:cd17426 262 IQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPL 341
|
410 420 430
....*....|....*....|....*....|..
gi 767975940 419 AGKLVDLTGEYKYMYMSCGAIVVAASVWLLIG 450
Cdd:cd17426 342 LGRLNDIYGDYKYTYWACGIVLIISSIYLFIG 373
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
19-451 |
1.38e-147 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 426.84 E-value: 1.38e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGgrifesfliftslriqcsftqsgscl 98
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGT-------------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17430 55 GPLCSILVNRFGCRPVMLVGGLLASLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAA 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17430 135 GSPVFLSALSPLGQILLEEYGWRGGFLILGGLLLNCCTCGAVMRP----------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPR 338
Cdd:cd17430 180 ----LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPR 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 IQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL 418
Cdd:cd17430 256 VVYLFSFAMLFNGLTDLCSATAADYGGLVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPS 335
|
410 420 430
....*....|....*....|....*....|...
gi 767975940 419 AGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGN 451
Cdd:cd17430 336 AGRLVDATKNYELIFYLAGSEVVLSALFLALGN 368
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
19-449 |
8.05e-117 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 348.39 E-value: 8.05e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYaggrifesfliftslriqcsftqsgsCL 98
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSL--------------------------FS 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17352 55 GPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVA 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17352 135 GSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR------------------------------------ 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIrpR 338
Cdd:cd17352 179 --------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRI--G 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 IQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL 418
Cdd:cd17352 249 RLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPI 328
|
410 420 430
....*....|....*....|....*....|.
gi 767975940 419 AGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd17352 329 AGLLRDYTGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
19-449 |
2.39e-103 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 314.02 E-value: 2.39e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGrifesfliftslriqcsftqsgscl 98
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGG------------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 gPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17425 56 -PLCSILVERFGCRVTVMLGGLLSGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALAST 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17425 135 GTSIGLTLWPLLSQYLLEEMGWRGSFLVFGGVLLNCCVCGAVMRP----------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPR 338
Cdd:cd17425 180 --------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGR 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 IQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL 418
Cdd:cd17425 252 RIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPL 331
|
410 420 430
....*....|....*....|....*....|.
gi 767975940 419 AGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd17425 332 AGLLVDITQQYSYVFYASSIFVVSAALFMGL 362
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
19-448 |
1.31e-86 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 271.57 E-value: 1.31e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMyaggrifesfliftslriqcsftQSGScl 98
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQ-----------------------QLAS-- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 gPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17423 56 -PVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALT 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGpnqttsksknktgkTEDDSSpkkiktkkSTWEK 258
Cdd:cd17423 135 GVGLSSFALSPLFQLLLDTYAWRGALLLLSALSLHLVPCGALLRPLA--------------LPGDPP--------APPRS 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 VNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPr 338
Cdd:cd17423 193 LSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 iQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL 418
Cdd:cd17423 272 -LHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPL 350
|
410 420 430
....*....|....*....|....*....|
gi 767975940 419 AGKLVDLTGEYKYMYMSCGAIVVAASVWLL 448
Cdd:cd17423 351 SGWLRDITGDYTASFLVAGSFLLLGSLILL 380
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
19-447 |
2.87e-75 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 241.58 E-value: 2.87e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYaggrifesfliFTSlriqcsftqsgscl 98
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMT-----------FTA-------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 gPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17422 56 -PLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIAST 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17422 135 GECFAVFAFAPAFTALKESIGWRYCLLVVGALQLNIVVCGALLR------------------------------------ 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRpR 338
Cdd:cd17422 179 --------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIR-K 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 IQYFFSFAIMFnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLM--DLVGAPRFSSAVGLVTIVECGPVLLGP 416
Cdd:cd17422 250 IYIELICVILL-CVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGP 328
|
410 420 430
....*....|....*....|....*....|.
gi 767975940 417 PLAGKLVDLTGEYKYMYMSCGAIVVAASVWL 447
Cdd:cd17422 329 PLGGVLVDWTQNYGSAFYSCAAGMALGAVFL 359
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
19-447 |
6.34e-56 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 190.79 E-value: 6.34e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSImlavmyaggrifesfliftslrIQCSFTqsgsCL 98
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSI----------------------VDCTTM----LC 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17424 55 APLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17424 135 GSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMR------------------------------------ 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldFSLFKhrGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPR 338
Cdd:cd17424 179 ------FLLMP--DFLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKY 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 IQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL 418
Cdd:cd17424 251 RYFCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPI 330
|
410 420
....*....|....*....|....*....
gi 767975940 419 AGKLVDLTGEYKYMYMSCGAIVVAASVWL 447
Cdd:cd17424 331 AGWLVDTTGTYTAAFLLSGFSMIFSSLLL 359
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
19-449 |
1.91e-46 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 165.77 E-value: 1.91e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMlavmyaggrifesflifTSLRIqcsftqsgsCL 98
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIM-----------------SSLRL---------SA 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17421 55 GPLASVACGRLGERWTSILGAFLVSAGFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLsSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17421 135 GMGLTF-ALAPFTQLLLDEYDWQGALLIFGGIMLNLVASGMLLRP----------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRpR 338
Cdd:cd17421 179 ----IDFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIK-K 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 IQYFFSFAIMFnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL 418
Cdd:cd17421 254 YHYHKAYLILC-GVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPL 332
|
410 420 430
....*....|....*....|....*....|.
gi 767975940 419 AGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd17421 333 AGWLYDYTQTYDCSFYLAGGCYLLSSVSFFL 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-449 |
9.39e-35 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 134.24 E-value: 9.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 20 WIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVmyaggrifesfliftslriqcsftqsGSCLG 99
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLV--------------------------GALLR 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 100 PVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYFY-RKRPMANGLAMA 178
Cdd:COG2223 58 IPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMrplgpnqttsksknktGKTEDDSSPKKIKTKKSTWek 258
Cdd:COG2223 137 GGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLF----------------LRDPPAGAAAAAKASLRDQ-- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRP 337
Cdd:COG2223 199 ------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSD--RIGG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 338 RIQYFFSFAIMfnGVCHLLCPLAQ-DYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGP 416
Cdd:COG2223 271 RRVLLIVFALM--ALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGP 348
|
410 420 430
....*....|....*....|....*....|...
gi 767975940 417 PLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 449
Cdd:COG2223 349 LLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
19-429 |
7.80e-34 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 131.88 E-value: 7.80e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHT-----TYSEIAWISSImlavmyAGGRIFesfliftslriQCSftq 93
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGAL------AMGMIF-----------FCS--- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 94 sgsclgPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMAN 173
Cdd:cd17420 61 ------PIVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVN 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 174 GLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKnktgkteddssPKKIKTKK 253
Cdd:cd17420 135 GFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSK-----------PGRRTLHS 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 254 STWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSK 333
Cdd:cd17420 204 RINLFLRKIFNVEIFKRKRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 334 YIRPRIqYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVL 413
Cdd:cd17420 284 PGVKKM-YLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMT 362
|
410
....*....|....*.
gi 767975940 414 LGPPLAGKLVDLTGEY 429
Cdd:cd17420 363 VGPPIAGLLRDSTGSY 378
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
19-449 |
3.05e-32 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 126.87 E-value: 3.05e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMyaggrifesfLIftslriqcsftqsgscL 98
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGIT----------LI----------------V 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17429 55 GPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTT 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17429 135 GTGFGTFLMTILLKYLCAEFGWRNAMFIQGAVSLNLCVCGALMR------------------------------------ 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIANSKYIrp 337
Cdd:cd17429 179 --------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCI-- 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 338 RIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGL--GFGSVSSVLFEtlmDLVGAPRFSSAVGLVTIVECGPVLLG 415
Cdd:cd17429 249 SVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFssGYFSLMPVVTE---DLVGIKNLANAYGIIICANGISALLG 325
|
410 420 430
....*....|....*....|....*....|....
gi 767975940 416 PPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd17429 326 PPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLL 359
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-450 |
2.99e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 123.83 E-value: 2.99e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 16 GGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVmYAGGrifesfliftslriqcsftqsg 95
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLG-YALG---------------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 96 sclGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYRK-RPMANG 174
Cdd:COG2271 62 ---QIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKeRGRALG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 175 LAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAgslmrplgpnqttsksknktgkteddsspkkiktkks 254
Cdd:COG2271 138 IFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 255 twekvnkyldfslfkhrGFLIYLSGNVIMFLGFFAPIIFLAPYAKD-QGIDEYSAAFLLSVMAFVDMFARPSVGLIANSK 333
Cdd:COG2271 181 -----------------RFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 334 YIRPRIQYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVL 413
Cdd:COG2271 244 GRRRKLVLAIGLLLA--ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
410 420 430
....*....|....*....|....*....|....*..
gi 767975940 414 LGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIG 450
Cdd:COG2271 322 LGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
100-429 |
7.17e-29 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 117.97 E-value: 7.17e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 100 PVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAG 179
Cdd:cd17464 61 PIVSVFTDLFGCRKTATGGAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 180 SPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQttsksknktgkteDDSSPKKIKTKKSTwekV 259
Cdd:cd17464 141 SSVFTITLPFLLRVLLDSVGLFNTLRVLCIFMFVLFLAGFTYKPLVPMK-------------KDKEGKKRKFKCPP---L 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 260 NKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIrPRI 339
Cdd:cd17464 205 KKIFNFNIWKSTGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVAD--YI-PGV 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 340 Q--YFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPP 417
Cdd:cd17464 282 KkvYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPP 361
|
330
....*....|..
gi 767975940 418 LAGKLVDLTGEY 429
Cdd:cd17464 362 IAGFLRDRLGSY 373
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-448 |
1.41e-28 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 116.99 E-value: 1.41e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGrifesfliftslriqcsftqsgscl 98
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQ------------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 gPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPA-LTIIGKYFYRKRPMANGLAM 177
Cdd:cd17355 56 -PFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILT 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 178 AGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPlgpnqttsksknktgkteDDSSPKKIKTKKSTWE 257
Cdd:cd17355 135 AGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLR------------------RRPADLALRAYDDASP 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 258 KVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRP 337
Cdd:cd17355 197 ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD-RYSPR 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 338 RIqyffSFAIMFNGVCHLLCPLA--QDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLG 415
Cdd:cd17355 276 RL----LAASYALRALGLALLLLlpFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALG 351
|
410 420 430
....*....|....*....|....*....|...
gi 767975940 416 PPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLL 448
Cdd:cd17355 352 PWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
19-449 |
3.56e-26 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 109.52 E-value: 3.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVmyaggrifesfliftslriqcsftqsGSCL 98
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGV--------------------------GLIA 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17428 55 SPVCSACVSSFGARPVTIFSGFMVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLIST 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwek 258
Cdd:cd17428 135 GSSVGLFIYAALQRELIELYGLDGCLLIVGALALNLLACGSLMR------------------------------------ 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIANSKYIRP 337
Cdd:cd17428 179 --------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 338 riQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETlMDLVGAPRFSSAVGLVTIVECGPVLLGPP 417
Cdd:cd17428 251 --LYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSIFPYVT-TKTVGIEKLGHAYGILMFFAGLGNSLGPP 327
|
410 420 430
....*....|....*....|....*....|..
gi 767975940 418 LAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd17428 328 IVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLL 359
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
17-453 |
7.07e-26 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 109.19 E-value: 7.07e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 17 GWGWIVVGAAFISIGFSYAFPkAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMyaggrifesfliftslriqcsftqsgS 96
Cdd:COG2807 15 GRWLLLLAIVLVALNLRPAIT-SVGPLLPEIRADLGLSATQAGLLTTLPLLAF--------------------------G 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 97 CLGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFItGLGLAFnLQPALT-IIGKYFYRKRPMANGL 175
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI-GAGIAV-GNVLLPgLIKRWFPDRVGLMTGL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 176 AMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKteddsspkkiktkkst 255
Cdd:COG2807 146 YTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR---------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 256 wekvnkyldfSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIAnSKYI 335
Cdd:COG2807 210 ----------SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLA-DRLG 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 336 RPRIQYFFSFAIMFNGVCHLLcpLAQDyTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPR-FSSAVGLVTIVECGPVLL 414
Cdd:COG2807 279 DRRPLLLLLGLLGLAGLLGLL--LAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAeAAALSGMAQSVGYLLAAL 355
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 767975940 415 GPPLAGKLVDLTGEYKY--MYMSCGAIVVAASVWLLIGNAI 453
Cdd:COG2807 356 GPLLVGALHDATGSWTAalLLLAALAVLMLVAGLLAGRPYV 396
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-407 |
3.52e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 100.43 E-value: 3.52e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 20 WIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGrifesfliftslriqcsftqsgsclg 99
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-------------------------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 100 PVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMA 178
Cdd:COG2814 63 PLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTgkteddsspkkiktkkstwek 258
Cdd:COG2814 142 GLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL--------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRP 337
Cdd:COG2814 201 ------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 338 RIqyFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIV 407
Cdd:COG2814 275 LL--LIGLLLL--ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-416 |
3.63e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.57 E-value: 3.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 21 IVVGAAFISIGFSYAFPkavtVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGrifesfliftslriqcsftqsgsclgP 100
Cdd:pfam07690 1 LFLAAFLAALGRSLLGP----ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ--------------------------P 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 101 VSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYFYRK-RPMANGLAMAG 179
Cdd:pfam07690 51 LAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAG 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 180 SPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddsSPKKIKTKKSTWEKV 259
Cdd:pfam07690 130 FGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP---------------------PPESKRPKPAEEARL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 260 NKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRI 339
Cdd:pfam07690 189 SLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767975940 340 QYFFSFAIMFnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGP 416
Cdd:pfam07690 269 LLALLLLILA-ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
20-449 |
1.88e-21 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 96.14 E-value: 1.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 20 WIVVGAAFI---SIGFSYAFpkavTVFFKEIQQIFHTTYSEIAWISSImlavmyaggrifesfliftslriqcsFTQSGS 96
Cdd:cd17353 3 WLVLLGAVLmhlILGYQYAW----SVFNPPLSSALGWSLASVALAFTL--------------------------TIVFLA 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 97 CLGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLA 176
Cdd:cd17353 53 ISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIV 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 177 MAGspVFLSSL--APFNQYLFNTFGWKGSFLILGSL-LLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSpkkiktKK 253
Cdd:cd17353 133 IAG--FGLGSLifSPLIAYLINTVGVPTTFLILGIIfLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPR------DY 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 254 STWEkvnkyldfSLFKHRGFLIYLSgnviMFLGFFAPIIF---LAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLI 329
Cdd:cd17353 205 TPRE--------MLRTPTFWLLWLM----FFLNATAGLMLigqAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 330 anSKYIRPRIQYFFSFAImfNGVCHLLCPLAQDYTSL-VLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVE 408
Cdd:cd17353 273 --SDKIGRKNTLSIAFLI--QGVAMFLLPFIGSVAVLfVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAK 348
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 767975940 409 CGPVLLGPPLAGkLVDLTGEYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd17353 349 GVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
19-450 |
5.89e-19 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 88.62 E-value: 5.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYaggrifesfliftslriqcsFTQsgscl 98
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGML--------------------LTQ----- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 gPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMA 178
Cdd:cd17314 56 -PILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTT 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPlgpnqttsksknktgKTEDDSSPKKIKTKKSTWEK 258
Cdd:cd17314 135 GYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGF---------------KEPPDNQARLHVQKKKTQTM 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 VnkyldfSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYS-AAFLLSVMAFVDMFARPSVGLIANsKYIRP 337
Cdd:cd17314 200 G------EIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVAD-FFGGR 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 338 RIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPP 417
Cdd:cd17314 273 LSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPM 352
|
410 420 430
....*....|....*....|....*....|...
gi 767975940 418 LAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIG 450
Cdd:cd17314 353 LGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
90-450 |
3.14e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 86.48 E-value: 3.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 90 SFTQSGSCLGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYF-YRK 168
Cdd:cd17325 39 AYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 169 RPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPlgpnqTTSKSKNKTGKTEDDSSPKK 248
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP-----EPRPPPNKRAVSAARLRSGL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 249 IKtkkstwekvnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVG 327
Cdd:cd17325 193 RL----------------LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 328 LIANskYIRPRIQYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIV 407
Cdd:cd17325 257 KLSD--RIGRKPLILIGLLLS--AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 767975940 408 ECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLLIG 450
Cdd:cd17325 333 FSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
100-429 |
4.64e-18 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 85.62 E-value: 4.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 100 PVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAG 179
Cdd:cd17465 61 PVVSIFTDRFGCRKTAMGGAAVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 180 SPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGslmrplgpnqttsksknktgkteddsspkkiktkkstwekv 259
Cdd:cd17465 141 SSLFSMLLPFLLKMVGDAIGLAHTFQVLSLFMFIQIFLS----------------------------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 260 nkyLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANS----KYI 335
Cdd:cd17465 180 ---LTYKVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDLipglKKI 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 336 RPRIQYFFSFAIMfngvcHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLG 415
Cdd:cd17465 257 YLQVASFLLLGIM-----SMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAG 331
|
330
....*....|....
gi 767975940 416 PPLAGKLVDLTGEY 429
Cdd:cd17465 332 PPIAGLLHDYFGSY 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
98-445 |
1.39e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.40 E-value: 1.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 98 LGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYRK-RPMANGLA 176
Cdd:cd06174 47 LQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPEReRGRALGLL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 177 MAGSPVFLSSLAPFNQYLF--NTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTeddsspkkikTKKS 254
Cdd:cd06174 126 QAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKS----------VLKL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 255 TWEkvnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQG-IDEYSAAFLLSVMAFVDMFARPSVGLIAnSK 333
Cdd:cd06174 196 LKR---------VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGgLSVAVAGLLLSLFGLAGALGSLLLGLLS-DR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 334 YIRPRIQYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVL 413
Cdd:cd06174 266 LIGRKPLLLIGLLLM--ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGA 343
|
330 340 350
....*....|....*....|....*....|..
gi 767975940 414 LGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 445
Cdd:cd06174 344 IGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
99-449 |
1.35e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 78.38 E-value: 1.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSvvqLYLTMG--FITGLGLAFNLQPALTIIGKYF---YRKRPMA- 172
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS---LYALLAsrALLGIGVAGIMTLATALIGDYFegeERAKMLGl 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 173 NGLAMAGSPVFLSSLAPFnqylFNTFGWKGSFLI-LGSLLLNACVAGSLMRPlgpnQTTSKSKNKTGKTEDDSSPKKikt 251
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGA----LAEIGWRAPFLVyLLALPVLILVLLFLPEP----ARKSKSAASPGAATAAALPWK--- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 252 kkstwekvnkyldfslfkhRGFLIYLSGNVIMFLgFFAPIIFLAPYAKDQGI-DEYSAAFLLSVMAFVDMFARPSVGLIa 330
Cdd:cd17473 198 -------------------RVLPIYFLAFLAMLL-FYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRL- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 331 nSKYIRPRIQYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECG 410
Cdd:cd17473 257 -KRRLGKRRLLAIGFALM--ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFL 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 767975940 411 PVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd17473 334 GQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
100-448 |
2.24e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 74.55 E-value: 2.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 100 PVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYFYRKRpMANGLAMAG 179
Cdd:cd17489 49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLV-LRLIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 180 SPVFLSSL--APFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMrplgpnqttsksknktgkteddsspKKIKTKKSTWE 257
Cdd:cd17489 127 LATTLAMAlgPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV-------------------------KDPPPVAAEEA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 258 KVNKYLDFSLFKHRGFLIYLSGNViMFLGFFAPIIFLAPYAKDQGIDeySAAFLLSVMAFVDMFARPSVGLIANskyiRP 337
Cdd:cd17489 182 EAGTRAFRRLVEKKVLPPALILFL-ASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSD----RK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 338 RIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPP 417
Cdd:cd17489 255 GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGL 334
|
330 340 350
....*....|....*....|....*....|.
gi 767975940 418 LAGKLVDLTGeYKYMYMSCGAIVVAASVWLL 448
Cdd:cd17489 335 LLGLVAELFG-YRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
90-445 |
3.61e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.06 E-value: 3.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 90 SFTQSGSCLGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYF-YRK 168
Cdd:cd17474 42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAGLGPLALTLIGDLFeGGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 169 RP-------MANGLAMAGSPVFLSSLApfnqylfnTFGWKGSFLILGSLLLNACVAGSLMrplgpnqttsksKNKTGKTE 241
Cdd:cd17474 121 RAkamglyeAALGLGIAVGPLLGGLLA--------AISWRYPFFLLAALIPVAFLAILFL------------LPEPKEKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 242 DDSSPKKIKTKKstwekvnkyldfSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKD-QGIDEYSAAFLLSVMAFVDM 320
Cdd:cd17474 181 KSSSATKLRDLK------------KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELlYGISPIIIGLLFAGWSVLLA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 321 FARPSVGLIANSKYIRPRIqYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSA 400
Cdd:cd17474 249 LGSLFVGRLLKKRFGARRI-LVIGLLLY--ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 767975940 401 VGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASV 445
Cdd:cd17474 326 SSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAV 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
266-478 |
8.58e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 69.62 E-value: 8.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 266 SLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPriqyFFSF 345
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR----VLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 346 AIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDL 425
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 767975940 426 TGeYKYMYMSCGAIVVAASVWLlignainYRLLAKERKEENARQKTRESEPLS 478
Cdd:COG2814 161 FG-WRWVFLVNAVLALLALLLL-------LRLLPESRPAARARLRGSLRELLR 205
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
98-448 |
2.47e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 68.42 E-value: 2.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 98 LGPVSS-----VLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAfNLQPALT--IIGKYFYRKRP 170
Cdd:cd17475 42 LGVAVSmlpagWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL-FLVGAGYG-SVQPGGGraIMRWFPPRERG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 171 MANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLM--RPLGPNQTTSKSknktgktedDSSPKK 248
Cdd:cd17475 120 LAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFyrEPPAASAATESA---------STLLRS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 249 IKtkkstwekvnkyldfSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVG 327
Cdd:cd17475 191 LK---------------EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRIGLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 328 LIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVS--SVLFETLMDLVGAPRFSSAVGL-V 404
Cdd:cd17475 256 RVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwnGLYLTLVAESAGPEQAGTALGLaN 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 767975940 405 TIVECGpVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLL 448
Cdd:cd17475 336 TINFIG-IAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-447 |
1.61e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.03 E-value: 1.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 21 IVVGAAFISIGFSYAfpkAVTVFFKEIQQIFHTTYSEIAWIssimLAVMYAGgrifesFLIFtslriqcsftqsgsclGP 100
Cdd:COG0738 11 IAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLL----LFAFFLG------YLLA----------------SL 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 101 VSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVqLYLTMGFITGLGLAF---NLQPALTIIGKYFYRKR-PMA---N 173
Cdd:COG0738 62 PAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-LLLLALFLLGLGLGLldvAANPYVAALGPETAASRlNLLhafF 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 174 GLAMAGSPVFLSSLAPFNqylfNTFGWKGSFLILGSLLLNACVAgslmrplgpnqtTSKSKNKTGKTEDDSSPKKIKTKK 253
Cdd:COG0738 141 SLGALLGPLLGGLLILLG----LSLSWHLPYLILAVLLLLLALL------------FLRSKLPEIEEEEEEAAGSAASLK 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 254 stwekvnkyldfSLFKHRGFLIYLsgnVIMFLGFFA---PIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLI 329
Cdd:COG0738 205 ------------SLLKNPRLLLGG---LAIFLYVGAegaIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 330 AnsKYIRPRIQYFFSFAIMFNGVchLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRfSSAVGLVTIVEC 409
Cdd:COG0738 270 L--KRFGPVRLLRLSALLAAVGL--LLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGI 344
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 767975940 410 GPVLLGPPLAGKLVDLTGEYKYMYMS--CGAIVVAASVWL 447
Cdd:COG0738 345 VGGAIGPPLIGFLADAFGLRAAFLVPlvCYLLILLLALAL 384
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
90-448 |
1.27e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 62.95 E-value: 1.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 90 SFTQSGSCLG-PVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYF-YR 167
Cdd:cd17324 41 SAYALGYALGaLLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL-LLARALAGLAHGGFWAIAAAYAADLVpPE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 168 KRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGslLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEddsspk 247
Cdd:cd17324 120 KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA--VLALLAALLLWRLLPSLPPKKPGSLGLLSSL------ 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 248 kiktkkstwekvnkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSV 326
Cdd:cd17324 192 -----------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 327 GLIANsKYIRPRIqyfFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRfSSAVGL-VT 405
Cdd:cd17324 255 GRLAD-RGGRRAL---LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLyLA 329
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 767975940 406 IVECGpVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLL 448
Cdd:cd17324 330 AYNLG-GALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
277-445 |
1.12e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.92 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 277 LSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHLL 356
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLD--RFGRKRLLLIGLLIF--ALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 357 CPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSC 436
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVA 156
|
....*....
gi 767975940 437 GAIVVAASV 445
Cdd:cd17489 157 AVLALLALL 165
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
282-449 |
1.59e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 282 IMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqYFFSFAIMfnGVCHLLCPLAQ 361
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD-RFGRKRL-LLLGLLLL--AVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 362 DYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVV 441
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALAL 161
|
....*...
gi 767975940 442 AASVWLLI 449
Cdd:cd17325 162 LALVLALL 169
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
282-448 |
1.43e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.32 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 282 IMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAImfngVCHLLCPLAQ 361
Cdd:cd17324 10 AIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI----LGNLLAALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 362 DYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVV 441
Cdd:cd17324 86 SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLAL 164
|
....*..
gi 767975940 442 AASVWLL 448
Cdd:cd17324 165 LAALLLW 171
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
101-445 |
1.52e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 53.46 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 101 VSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYR-KRPMANGLAMAG 179
Cdd:cd06180 53 LASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALR-FLAGAASAFVFVFGSNLVLHHATAaGRGHLIGLLFAG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 180 SPV--FLSSLApfnQYLFNTFG--WKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGkteddsspkkiktkkst 255
Cdd:cd06180 132 VGLgiALSGLL---VPAGLGGGlsWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESA----------------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 256 wekvnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLlsvMAFVDMFARPSVGLianSKYI 335
Cdd:cd06180 192 -----------PGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLL---WSLFGLAAVPSCFL---WGAL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 336 RPRIQYFFSFAIMF--NGVCHLLCPLAQDYTSLVLYAVFFGLGF-GSVSSVLFETLMdlVGAPRFSSAVGLVTIVECGPV 412
Cdd:cd06180 255 SDRWGTRRALAANLlvQAVGVLLPLLSPGPAGLVLSAVLFGGTFmAITALVMALARE--LAPPAAPRALALMTASFGVGQ 332
|
330 340 350
....*....|....*....|....*....|...
gi 767975940 413 LLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 445
Cdd:cd06180 333 ILGPLLAGWLADATGGFAPALILAAAALVVAAL 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
112-468 |
2.09e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.37 E-value: 2.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 112 RPVVIAGGLLCCLGMVLASFSSSVVQ-----LYLTMGFITGLGLAFNLQPALTIIGKYF--YRKRPMANGLAMAGSPV-- 182
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPtgkliYALVTYLLLGLAYTLVNIPYSALGAELTpdYEERTRLSSWRFAFAGLgg 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 183 FLSSLAPFnqYLFNTF------GWKGSFLILGSLLLnACVAGSLMRplgpnqttsksknktgkTEDDSSPKKikTKKSTW 256
Cdd:COG2211 161 LLASVLPP--PLVAAFggdaalGYRLTALIFAVLGL-LAFLLTFFG-----------------TKERPVPEE--EKVSLK 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 257 EKVnkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIAnsKYI 335
Cdd:COG2211 219 ESL-----KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLA--KRF 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 336 RPRIQYFFSFAIMfnGVCHLLCPLAQ--DYTSLVLYAVFFGLGFGSVSSVLFETLMDLV-------GAPRFSSAVGLVTI 406
Cdd:COG2211 292 GKKKAFIIGLLLA--ALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTF 369
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975940 407 VECGPVLLGPPLAGKLVDLTG-------------EYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENAR 468
Cdd:COG2211 370 AIKLGQALAGALAGLLLALFGyvagaaqspsaltGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
20-449 |
7.51e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 51.03 E-value: 7.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 20 WIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMlavmyaggriFESFLIFtslriqcsftqsgsclG 99
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAF----------FLGYALF----------------Q 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 100 PVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMA 178
Cdd:cd17319 56 VPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 179 GSPVFLSSLAPFNQYLFNTFGWKGSFLILGslllnacVAGSLMRPLgpnqttsksknktgkteddsspkkiktkkstWek 258
Cdd:cd17319 135 GAPLGAAIGPPLSGWLLLLFGWRWAFIIEG-------LLGLLLAVL-------------------------------W-- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 259 vnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPR 338
Cdd:cd17319 175 --------WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 339 IQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL 418
Cdd:cd17319 247 RRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
410 420 430
....*....|....*....|....*....|.
gi 767975940 419 AGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd17319 327 IGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
18-206 |
9.09e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.58 E-value: 9.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 18 WGWIVVGAAFISIGFSYAfpkAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGrifesfliftslriqcsftqsgsc 97
Cdd:COG0477 14 RALLALALGTFLEGLDFT---IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGL------------------------ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 98 lgPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLA 176
Cdd:COG0477 67 --LLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIA-ARALQGIGAGGLMPGALALIAELFpARERGRALGLW 143
|
170 180 190
....*....|....*....|....*....|.
gi 767975940 177 MAGSPVFLsSLAPF-NQYLFNTFGWKGSFLI 206
Cdd:COG0477 144 GAAIGLGL-ALGPLlGGLLVAALGWRWIFLI 173
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
97-221 |
9.48e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.66 E-value: 9.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 97 CLGPVSsvlvNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGL 175
Cdd:cd17365 53 LAGPLA----DRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAITLVSEYApARRRSLAVTL 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 767975940 176 AMAGSPV------FLSSLapfnqyLFNTFGWKGSFLILGS--LLLNACVAGSLM 221
Cdd:cd17365 128 MFCGYPLgaalggFLAAA------LIPAFGWRSVFLLGGVppLILLPLLRGTLL 175
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
273-449 |
2.12e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.05 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 273 FLIYL-SGNVIMFLGFFAPIIflapyAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqyfFSFAIMFNG 351
Cdd:TIGR00895 23 FLIMLmDGYDLAAMGFAAPAI-----SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLAD-RIGRRRV---LLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 352 VCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKY 431
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG-WRS 172
|
170
....*....|....*...
gi 767975940 432 MYMsCGAIVVAASVWLLI 449
Cdd:TIGR00895 173 LFY-VGGIAPLLLLLLLM 189
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
277-449 |
2.13e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 2.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 277 LSGNVIMFLGFFAPIIFLAPY-AKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIanSKYIRPRIQYFFSFAIMfnGVCHL 355
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRL--SDRFGRRRVLLIGLLLF--ALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 356 LCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMS 435
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....
gi 767975940 436 CGAIVVAASVWLLI 449
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
279-453 |
5.65e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.33 E-value: 5.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 279 GNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIqyFFSFAIMFNGVCHLLCP 358
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD--RFGRRR--VLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 359 LAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIveCGPV--LLGPPLAGKLVDLTGeYKYMYMSC 436
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNA--GGPLggALAPPLLGWLLAAFG-WRAAFLIL 170
|
170
....*....|....*..
gi 767975940 437 GAIVVAASVWLLIGNAI 453
Cdd:COG2271 171 GLPGLLLALLRFWLLAL 187
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
99-210 |
5.83e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.10 E-value: 5.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYFYR-KRPMANGLAM 177
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII-ARFLQGFGAAFALVAGAALIADIYPPeERGVALGLMS 93
|
90 100 110
....*....|....*....|....*....|...
gi 767975940 178 AGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSL 210
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWRAPFLFLAIL 126
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
39-378 |
1.20e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.57 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 39 AVTVFFKEIQQIFHTTYSEIAWISSimlavmyaggrifeSFLIFTSLRIqcsftqsgsclgPVSSVLVNKYGSRPVVIAG 118
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVIT--------------SYLLALAIMI------------PLSGWLADRFGTRRLFLTA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 119 GLLCCLGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYFYR-KRPMAngLAMAGSPVflsSLAP-----FNQ 192
Cdd:cd17503 68 LALFTLGSLLCGLAPNLASL-IIFRILQGFGGGVLIPLAQTILLRIYPPeKRGAA--MGLVGLVI---LLAPaigptLGG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 193 YLFNTFGWKGSFLILgsllLNACVAGSLMRPLgpnqttsksknktgkteddsspkkiktkkstwekvnkyLDFSLFKHRG 272
Cdd:cd17503 142 WLTDNLSWRWIFYIN----LPIGILALLLAPL--------------------------------------LDLRLFKDRN 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 273 FLIYLSGNVIMFLGFFAPIIFLAPYAkdQGIDEYSA---AFLLSVMAFVDMFARPSVGLIanSKYIRPRIQYFFSFAIMF 349
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYL--QNVLGYSAfesGLVLAPGGLASAILSPLVGRL--LDKFGPRLLLLAGLLLLA 255
|
330 340
....*....|....*....|....*....
gi 767975940 350 nGVCHLLCPLAQDYTSLVLYAVFFGLGFG 378
Cdd:cd17503 256 -LGTLLLAFLTPDTSLWLIILPLFIRGLG 283
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
105-380 |
1.35e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 47.25 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 105 LVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAfNLQPALTIIGKYFYRKRP-----MANGLAMAG 179
Cdd:cd17341 57 LCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIggaagGIAGAGNMG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 180 SPV---FLSSLAPFNQYLFNTFGWKGSFLILGSLLLnacVAGSLMRPLGPNQTTSKSKNKTGKTEddssPKKIKTKKSTW 256
Cdd:cd17341 136 VAVsqlLAPLIAGAIVFDGGFVGWRNAFFVPGILLA---IAAVLVLLFGDDLPTGKASALEFLKV----QLAVLKNYRTW 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 257 EkvnkyldFSLFkhrgfliYlsgnVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANskYI 335
Cdd:cd17341 209 I-------LSLL-------Y----GVTFGSFVGFSNVLPTYFKTRfGLPLVTAGILAALFPLAGALARPAGGWLSD--RF 268
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 767975940 336 RPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFF-------GLGFGSV 380
Cdd:cd17341 269 GGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFvalglgaGAGNGSV 320
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
44-393 |
1.62e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 47.19 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 44 FKEIQQIFHTTYSEIAWISSIMLAvMYAGGRIFesfliftslriqcsftqsgscLGPVSSvlvnKYGSRPVVIAGGLLCC 123
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLL-GFALGQLL---------------------YGPLSD----RFGRRPVLLAGLLLFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 124 LGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTII-GKYFYRKRPMANGLAMAG---SPVflssLAP-FNQYLFNTF 198
Cdd:cd17320 76 LASLLCALASSIEQL-LIARFLQGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMIlaiAPA----LAPlLGGLLLLFF 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 199 GWKGSFLILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddSSPKKIKTKKSTWEKVNKYldFSLFKHRGFLIYLS 278
Cdd:cd17320 151 GWRAIFVFLALLGLLLLLLVLLFLP--------------------ETLPEEKRKPLLSSLLRAY--KRVLKNRRFLGYAL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 279 GNVIMFLGFF-----APIIFLAPYakDQGIDEYSAAFLLSVMAFVdmfarpsVGLIANSKYIR----PRIQYFFSFAIMF 349
Cdd:cd17320 209 ALGLSFAGLFaylaaAPFIYIEQL--GLSPAQFGLLFALNAIALI-------LGSLLNGRLVRrfgpRRLLRLGLLLLLA 279
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 767975940 350 NGVCHLLCPLAQD--YTSLVLYAVFFGLGFGSVSSVLFETLMDLVG 393
Cdd:cd17320 280 AALVLLLAALLGGlsLWPLVAPLFLIFFGFGLIFPNATSLALEPFP 325
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
98-449 |
2.62e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 98 LGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASF-----SSSVVQLYLTMgFITGLGLAFNlQPALT-----IIGKyfyR 167
Cdd:cd06173 50 FSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLA-FLLGIASAFF-GPARQallpeLVPK---E 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 168 KRPMANGL---AMAGSPVFLSSLAPFnqyLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDds 244
Cdd:cd06173 125 QLVRANALnslATQLARIIGPALGGL---LVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLRE-- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 245 spkkiktkkstwekvnkylDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAP-YAKDQGIDEYSAAFLLSVMAFVDMFAr 323
Cdd:cd06173 200 -------------------GLRYLRRSPLLRLLLLALALFALLGGALTVLLPlLAKEVLGGGAAGYGLLLAAFGVGALL- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 324 psVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGsVSSVLFETLMDLVGAPRFSSAV-G 402
Cdd:cd06173 260 --GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGG-LFNVPLNTLLQLRVPDELRGRVfS 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 767975940 403 LVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd06173 337 VYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-212 |
5.94e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.26 E-value: 5.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 60 WISSIMLAVMYAGGRIFESFL-IFTSLRIQCSFTQSGSCLGPVSSV----------LVNKYGSRPVVIAGGLLCCLGMVL 128
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLpLYAAELGGLSPAQIGLLFGAQGLAsalsqppagkLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 129 ASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYF-YRKRPMANG-------LAMAGSPVFLSslapfnqYLFNTFGW 200
Cdd:cd17325 282 LPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVpPEGRGTAMGlfntafsLGMVLGPLLGG-------FLYDAFGF 353
|
170
....*....|..
gi 767975940 201 KGSFLILGSLLL 212
Cdd:cd17325 354 ATPFLAAAALLL 365
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
101-208 |
1.58e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.88 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 101 VSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAG 179
Cdd:TIGR00895 71 FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYApKRFRGTAVGLMFCG 149
|
90 100
....*....|....*....|....*....
gi 767975940 180 SPVFLSSLAPFNQYLFNTFGWKGSFLILG 208
Cdd:TIGR00895 150 YPIGAAVGGFLAGWLIPVFGWRSLFYVGG 178
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
99-222 |
3.12e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.97 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSsvlvNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTII-GKYFYRKRPMANGLAM 177
Cdd:PRK11652 64 GPLS----DRVGRRPVILVGMSIFILGTLVALFAHSLTVL-IAASAIQGLGTGVGGVMARTLPrDLYEGTQLRHANSLLN 138
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 767975940 178 AGSpVFLSSLAPF-NQYLFNTFGWKGSFLILgsLLLNACVAGSLMR 222
Cdd:PRK11652 139 MGI-LVSPLLAPLiGGLLTTLFGWRACYLFL--LLLGAGVTFSMAR 181
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
91-445 |
3.41e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 3.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 91 FTQSGSCLGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYFYRKRP 170
Cdd:cd17478 40 FSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLL-LLLVALAGIGSAAFHPEGARLASQAAGGRRG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 171 MANGLAMAG-------SPVFLSslapfnqYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKsknktgktedD 243
Cdd:cd17478 119 LAMSIFSVGgnlgfalGPLIAA-------ALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKA----------A 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 244 SSPKKIKTKKSTWekvnkyldfslfkhRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFAR 323
Cdd:cd17478 182 AKSSARSTLKGVW--------------RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 324 PSVGLIanSKYIRPRIQYFFSFAIMFngVCHLLCPLAQDYTSLVLYAV--FFGLGFGSVSSVLFETLMdlvgaPRFSSAV 401
Cdd:cd17478 248 LIGGPL--SDRFGRRRVIIASLLLAA--PFLLLFLLTPGIWSYILLVLagFLLFASFPVTVVLAQELL-----PGNVGLA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 767975940 402 -GLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASV 445
Cdd:cd17478 319 sGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLGAL 362
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
99-161 |
6.18e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.18 E-value: 6.18e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTII 161
Cdd:cd17504 234 GPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV 296
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
271-405 |
6.53e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.16 E-value: 6.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 271 RGFLIYLSGNVIMFLGFFAPIIFLAPYAKD-QGIDEYSAAFLLSVMAFVDMFARPSVGLIANSkyIRPRIQYFFSFAIMF 349
Cdd:cd17321 168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADR--FGPRLVLVAGLLLTA 245
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 767975940 350 NGVCHL-LCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVT 405
Cdd:cd17321 246 VGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILN 302
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
99-161 |
1.08e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.39 E-value: 1.08e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMG--FITGLGLAFNLQPALTII 161
Cdd:cd17321 221 APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPglVLLGLGLGLFATPLTNAA 285
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-449 |
2.15e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 20 WIVVGAAFISIGFSYAFPkAVTVFFkeiqqifHTTYSEIAWISSIMLAVMYAGGRIFesfliftslriqcsftqsgsclG 99
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWP-FMAIYL-------HQQLGLSASIVGLVLALSAVAGIVA----------------------S 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 100 PVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVqLYLTMGFITGLGLAFNLQPALTIIG--------KYFYRKRPM 171
Cdd:cd17329 53 LIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW-LFAIALVLTGFGGGLFEPASEAMIAdvttpenrTRAFSLLYW 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 172 ANGLAMAGSPVFLSSLApfnQYLFNTFgwkgsFLILGSLLLNACVAgsLMRPLGPNQTTSKSKNKTGkteddsSPKKIKT 251
Cdd:cd17329 132 AINLGVAIGPLLGGLLL---LYSFRLL-----FLAAAVLFLLAALV--LLFLLPETRPKRRAAEKTE------ILRGYKI 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 252 KkstwekvnkyldfslFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSA-AFLLSVMAFVDMFARPSVGLIA 330
Cdd:cd17329 196 V---------------LRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPVARLV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 331 NSKYIRPRIqyffSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLG---FGSVSSVLFETLMDLVGAPRFSSAVGLVTIV 407
Cdd:cd17329 261 ERFRLRKIL----MIGILLFAIGFAVLAFANTLAVLILAMIVLTLGemlVFPAVQTLVAALAPPDKRGSYMGFYALAWGL 336
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 767975940 408 EcgpVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLLI 449
Cdd:cd17329 337 G---RAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALLLG 374
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
99-446 |
2.32e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVqLYLTMGFITGLGLAFNL---QPAL----------TIIGKYF 165
Cdd:cd17477 48 SPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLFvvsESWLnalatnenrgRVLGLYS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 166 yrkrpMANGLAMAGSPVFLSslapfnqyLFNTFGWKgSFLILGSLLLNACVAGSLMRPLGPNQttsksknktgKTEDDSS 245
Cdd:cd17477 127 -----TVLGLGFALGPLLLA--------LVGTAGAL-PFLIAAVLLLLALVPLLLTRRAAPEI----------EEAESIS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 246 PKKIKtkkstwekvnkyldfslfkhRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPS 325
Cdd:cd17477 183 LRRLL--------------------RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 326 VGLIANsKYIRPRIQYFFSFAIMfngVCHLLCPLAqDYTSLVLYAVFF--GLGFGSVSSVLFETLMDLVGAPRFSSAVGL 403
Cdd:cd17477 243 LGWLAD-RFDRRRVLLGCALLGA---LAALLLPLV-PGLPLALLVLLFlwGGAAGPLYTLALALAGDRLPGDELVAANAA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 767975940 404 VTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW 446
Cdd:cd17477 318 LLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
99-155 |
3.21e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.93 E-value: 3.21e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975940 99 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTM---GFITGLG-LAFNLQ 155
Cdd:cd17393 51 MPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALflfGAANGALdVAMNAQ 111
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
274-450 |
4.62e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.50 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 274 LIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIA---NSKYIRpRIQYFFSFAIMF 349
Cdd:COG2211 13 LAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSdrtRTRWGR-RRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 350 nGVCHLLCPLA--QDYTSLVLYAVFFGLGFG---SVSSVLFETLM-DLVGAPR-------FSSAVGLVTIvecgpvLLGP 416
Cdd:COG2211 92 -ALSFVLLFTApdLSPTGKLIYALVTYLLLGlayTLVNIPYSALGaELTPDYEertrlssWRFAFAGLGG------LLAS 164
|
170 180 190
....*....|....*....|....*....|....*....
gi 767975940 417 PLAGKLVDLTGE-----YKYMYMSCGAIVVAASVWLLIG 450
Cdd:COG2211 165 VLPPPLVAAFGGdaalgYRLTALIFAVLGLLAFLLTFFG 203
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
98-427 |
5.64e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 39.10 E-value: 5.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 98 LGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTmgFITGLGLAFN--LQPALtiIGKYFYRKRPMANGL 175
Cdd:cd17339 50 FSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLGT--ALAGAGIAVGnvLLPSL--IKRDFPRRVGLMTGL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 176 ---AMAGSPVFLSSLA-PFNQYLFntFGWKGSFLILGSL-LLNACVAGSLMRPLGPNQTTSKSKnktgkteddsSPKKIK 250
Cdd:cd17339 126 yttSMNLGAALASGLSvPLAQALG--GGWRGALAIWALPaLLALLIWLPQLRRRKRAAAAAAPL----------TKISVW 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 251 TKKSTWEkvnkyldfslfkhrgfliylsgnVIMFLG-----FFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPS 325
Cdd:cd17339 194 RSPLAWQ-----------------------VTLFMGlqsllFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 326 VGLIAnSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQdytSLVLYAVFFGLGFGSvssvLFETLMDLVG--APRFSSAVGL 403
Cdd:cd17339 251 VPILA-TRLKNQRPIVVLLAVLFIIGVLGLLFAPTA---LALLWAVLLGLGGGA----AFSLALTLISlrSSDPAEAAAL 322
|
330 340
....*....|....*....|....*..
gi 767975940 404 VTIVECGPVLL---GPPLAGKLVDLTG 427
Cdd:cd17339 323 SGMAQSVGYLLaalGPLLFGVLHDLTG 349
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
288-448 |
6.84e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 38.75 E-value: 6.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 288 FAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKyirPRIQYFFSFAIMFNGVChLLCPLAQDYTSLV 367
Cdd:PRK10213 37 FLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQAT---DRRYVVILFAVLLTLSC-LLVSFANSFSLLL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 368 LYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWL 447
Cdd:PRK10213 113 IGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIG-WRNVFNAAAVMGVLCIFWI 191
|
.
gi 767975940 448 L 448
Cdd:PRK10213 192 I 192
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-223 |
7.80e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.70 E-value: 7.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 20 WIVVGAAFISIGFSYAFpkaVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGrifesfliftslriqcsftqsgsclg 99
Cdd:COG2271 183 WLLALAYFLVYFALYGF---LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGS-------------------------- 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975940 100 PVSSVLVNKYGSR--PVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYRK-RPMANGLA 176
Cdd:COG2271 234 LLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALL-FLAGFGLGGAFGLLWALAAELFPKKaRGTASGLV 312
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 767975940 177 MAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRP 223
Cdd:COG2271 313 NTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| |
