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MND2 Mnd2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854843, updated on 17-May-2024

Summary

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Gene symbol
MND2
Gene description
Mnd2p
Primary source
FungiDB:YIR025W
Locus tag
YIR025W
See related
SGD:S000001464; AllianceGenome:SGD:S000001464; VEuPathDB:YIR025W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin ligase inhibitor activity. Involved in deactivation of mitotic spindle assembly checkpoint; nuclear division; and regulation of cellular protein metabolic process. Located in nucleus. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MND2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (403659..404765)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Dal81p Neighboring gene Ina22p Neighboring gene tyrosine protein phosphatase YVH1 Neighboring gene allantoinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II. Tan GS, et al. Mol Biol Cell, 2011 Feb 1. PMID 21118994, Free PMC Article
  2. Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. da Fonseca PC, et al. Nature, 2011 Feb 10. PMID 21107322, Free PMC Article
  3. The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces cerevisiae. McDonald CM, et al. Genetics, 2009 Feb. PMID 19087957, Free PMC Article
  4. Mitotic phosphorylation of the anaphase-promoting complex inhibitory subunit Mnd2 is necessary for efficient progression through meiosis i. Torres MP, et al. J Biol Chem, 2007 Jun 15. PMID 17459880
  5. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Foster SA, et al. Mol Cell, 2012 Sep 28. PMID 22940250, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that mitotic phosphorylation of Mnd2 is necessary for anaphase-promoting complex-mediated progression beyond the first meiotic nuclear division.
    Title: Mitotic phosphorylation of the anaphase-promoting complex inhibitory subunit Mnd2 is necessary for efficient progression through meiosis i.
  2. The requirement of Mnd2p for anaphase-promoting complex/cyclosome function appears to be negligible under standard laboratory conditions.
    Title: In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p.
  3. Mnd2, a factor known to associate with APC components, prevents premature securin degradation in meiosis by APC(Ama1).
    Title: Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ubiquitin ligase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in deactivation of mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of anaphase-promoting complex-dependent catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle assembly checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mnd2p
NP_012291.1
  • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    403659..404765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179547.1 → NP_012291.1  TPA: Mnd2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012291.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVV6, P40577
    UniProtKB/TrEMBL
    A0A8H4F9G7, C7GLT1, G2WFV3, N1P0R8
    Conserved Domains (1) summary
    pfam05841
    Location:8 → 136
    Apc15p; Apc15p protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40577.1

Gene LinkOut

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