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CARD19 caspase recruitment domain family member 19 [ Homo sapiens (human) ]

Gene ID: 84270, updated on 5-Mar-2024

Summary

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Official Symbol
CARD19provided by HGNC
Official Full Name
caspase recruitment domain family member 19provided by HGNC
Primary source
HGNC:HGNC:28148
See related
Ensembl:ENSG00000165233 MIM:617726; AllianceGenome:HGNC:28148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BinCARD; C9orf89
Summary
Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 13.5), testis (RPKM 6.7) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
9q22.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (93096217..93113283)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (105262835..105279901)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95858499..95875565)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95821078-95822058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95822059-95823039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28609 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95824548-95825115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28611 Neighboring gene sushi domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 12079 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95844809-95845437 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95852051-95852551 Neighboring gene uncharacterized LOC101927993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20037 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95869787-95870287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95875683-95876631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95876632-95877579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95881665-95882481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95882482-95883297 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:95887196-95887360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95888965-95889616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28616 Neighboring gene ninjurin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95893060-95893658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95893659-95894256 Neighboring gene uncharacterized LOC124902212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20041 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:95897247-95897843 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95905234-95906106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95906107-95906979 Neighboring gene Sharpr-MPRA regulatory region 13679 Neighboring gene uncharacterized LOC124902213

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Chen KE, et al. Acta Crystallogr D Biol Crystallogr, 2013 May. PMID 23633586
  2. CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement. Rios KE, et al. Cell Immunol, 2020 Oct. PMID 32763502, Free PMC Article
  3. BinCARD2 as a positive regulator of interferon response in innate immunity. Suzuki H, et al. Biochem Biophys Res Commun, 2019 Apr 2. PMID 30795865
  4. Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. Woo HN, et al. FEBS Lett, 2004 Dec 17. PMID 15637807
  5. Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin α7 is counteracted by TBK1-p62 axis-mediated autophagy. Wang X, et al. Cell Mol Immunol, 2022 Oct. PMID 36056146, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-kappaB activation after TCR engagement.
    Title: CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement.
  2. BinCARD isoform2 (BinCARD2) is a one of CARD proteins involved in apoptosis and inflammation. BinCARD2 knock down suppresses innate immune responses induced by 3pRNA, poly(I:C) and vesicular stomatitis virus (VSV).
    Title: BinCARD2 as a positive regulator of interferon response in innate immunity.
  3. the crystal structure of BinCARD reveals that all three cysteines were oxidized
    Title: The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized.
  4. BinCard inhibits BCL10-mediated activation of NF-kappa B.
    Title: Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11115, MGC110898

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CARD domain binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of canonical NF-kappaB signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
caspase recruitment domain-containing protein 19
Names
Bcl10-interacting protein with CARD
bcl10-interacting CARD protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318010.2 → NP_001304939.1  caspase recruitment domain-containing protein 19 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks two alternate exons in the coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL451065, DB550397, DN998463, HY005780
    Conserved Domains (1) summary
    cl14633
    Location:10 → 50
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. NM_001318011.2 → NP_001304940.1  caspase recruitment domain-containing protein 19 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AA804861, BM930683, HY005780
    Related
    ENST00000468781.5
    Conserved Domains (1) summary
    cd13785
    Location:10 → 95
    CARD_BinCARD_like; BinCARD (Bcl10-interacting protein with CARD)

  3. NM_032310.5 → NP_115686.3  caspase recruitment domain-containing protein 19 isoform 1

    See identical proteins and their annotated locations for NP_115686.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL451065, BC004500, DB550397, HY005780
    Consensus CDS
    CCDS6702.2
    Related
    ENSP00000364613.2, ENST00000375464.7
    Conserved Domains (1) summary
    cd13785
    Location:10 → 95
    CARD_BinCARD_like; BinCARD (Bcl10-interacting protein with CARD)

RNA

  1. NR_134464.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and retains two introns, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK091611, AL451065, BC038856, DB550397, HY005780

  2. NR_134465.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) retains two introns, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL451065, BC038856, DB550397, HY005780
    Related
    ENST00000466409.1

  3. NR_134466.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL451065, BC091476, DB550397, HY005780
    Related
    ENST00000490488.5

  4. NR_134467.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA804861, BC004500, BX354102, HY005780

  5. NR_134468.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA804861, CD676329, HY005780

  6. NR_160511.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL451065

  7. NR_160512.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL451065

  8. NR_160513.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL451065

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    93096217..93113283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007061361.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    105262835..105279901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363983.1 → XP_054219958.1  caspase recruitment domain-containing protein 19 isoform X1

RNA

  1. XR_008488080.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LW7.1 GenPept UniProtKB/Swiss-Prot:Q96LW7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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