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SEC7-like guanine nucleotide exchange family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825257, updated on 18-Sep-2024

Summary

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Official Full Name
SEC7-like guanine nucleotide exchange family protein
Primary source
TAIR:AT3G60860
Locus tag
AT3G60860
See related
Araport:AT3G60860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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Genomic context

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Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (22484397..22491935)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 65-4 Neighboring gene uncharacterized protein Neighboring gene AT-hook motif nuclear-localized protein 18 Neighboring gene dihydrodipicolinate synthase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BEN3/BIG2 ARF GEF is Involved in Brefeldin A-Sensitive Trafficking at the trans-Golgi Network/Early Endosome in Arabidopsis thaliana. Kitakura S, et al. Plant Cell Physiol, 2017 Oct 1. PMID 29016942
  2. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
  3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BEN3/BIG2 is an guanine nucleotide exchange factors for ADP ribosylation factor component, which confers brefeldin A sensitivity to the trans-Golgi Network/Early Endosome in Arabidopsis.[BEN3]
    Title: BEN3/BIG2 ARF GEF is Involved in Brefeldin A-Sensitive Trafficking at the trans-Golgi Network/Early Endosome in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_115950.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SEC7-like guanine nucleotide exchange family protein
NP_191645.1
  • SEC7-like guanine nucleotide exchange family protein; FUNCTIONS IN: binding, ARF guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity; INVOLVED IN: regulation of ARF protein signal transduction; LOCATED IN: intracellular; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: SEC7-like (InterPro:IPR000904), Armadillo-type fold (InterPro:IPR016024), Protein of unknown function DUF1981, SEC7 associated (InterPro:IPR015403); BEST Arabidopsis thaliana protein match is: SEC7-like guanine nucleotide exchange family protein (TAIR:AT1G01960.1); Has 2962 Blast hits to 2694 proteins in 246 species: Archae - 0; Bacteria - 33; Metazoa - 1475; Fungi - 672; Plants - 315; Viruses - 0; Other Eukaryotes - 467 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    22484397..22491935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115950.4 → NP_191645.1  SEC7-like guanine nucleotide exchange family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191645.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LZX8
    UniProtKB/TrEMBL
    A0A654FJM2
    Conserved Domains (6) summary
    PLN03076
    Location:1 → 1793
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    pfam01369
    Location:617 → 799
    Sec7; Sec7 domain
    pfam09324
    Location:1166 → 1249
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:345 → 499
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:1346 → 1421
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:6 → 217
    DCB; Dimerization and cyclophilin-binding domain of Mon2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LZX8.1

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