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SUVH2 SU(VAR)3-9 homolog 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817892, updated on 18-Sep-2024

Summary

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Official Symbol
SUVH2
Official Full Name
SU(VAR)3-9 homolog 2
Primary source
TAIR:AT2G33290
Locus tag
AT2G33290
See related
Araport:AT2G33290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATSUVH2; F4P9.6; F4P9_6; SDG3; SET DOMAIN-CONTAINING PROTEIN 3; SU(VAR)3-9 homolog 2
Summary
Encodes a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression and act as histone methyltransferases. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. Gene is expressed in rosettes, stems, floral buds, and flowers by RT-PCR.
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Genomic context

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See SUVH2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (14108529..14112464)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene atypical CYS HIS rich thioredoxin 3 Neighboring gene Major facilitator superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription elongation factor (TFIIS) family protein Neighboring gene auxin-induced protein 13 Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUVH2 and SUVH9 Couple Two Essential Steps for Transcriptional Gene Silencing in Arabidopsis. Jing Y, et al. Mol Plant, 2016 Aug 1. PMID 27216319
  2. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Johnson LM, et al. Nature, 2014 Mar 6. PMID 24463519, Free PMC Article
  3. Developmentally non-redundant SET domain proteins SUVH2 and SUVH9 are required for transcriptional gene silencing in Arabidopsis thaliana. Kuhlmann M, et al. Plant Mol Biol, 2012 Aug. PMID 22669745, Free PMC Article
  4. Epigenetic programming via histone methylation at WRKY53 controls leaf senescence in Arabidopsis thaliana. Ay N, et al. Plant J, 2009 Apr. PMID 19143996
  5. Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. Naumann K, et al. EMBO J, 2005 Apr 6. PMID 15775980, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA polymerase epsilon interacts with SUVH2/9 to repress the expression of genes associated with meiotic DSB hotspot in Arabidopsis.
    Title: DNA polymerase epsilon interacts with SUVH2/9 to repress the expression of genes associated with meiotic DSB hotspot in Arabidopsis.
  2. Study propose that SUVH2 and SUVH9 bind to the methylated DNA and facilitate the recruitment of a chromatin-remodeling complex to the target loci in association with MORC proteins.
    Title: SUVH2 and SUVH9 Couple Two Essential Steps for Transcriptional Gene Silencing in Arabidopsis.
  3. Our CHIP assay demonstrated that SUVH2 and SUVH9 are required for the occupancy of Pol V at RdDM loci and facilitate the production of Pol V-dependent noncoding RNAs
    Title: The SET domain proteins SUVH2 and SUVH9 are required for Pol V occupancy at RNA-directed DNA methylation loci.
  4. SUVH2 and SUVH9 functions in RdDM and TGS are overlapping. Pol V specific transcripts were reduced in suvh2 suvh9 plants. This might indicate a role of these SUVH proteins in Pol V complex recruitment.
    Title: Developmentally non-redundant SET domain proteins SUVH2 and SUVH9 are required for transcriptional gene silencing in Arabidopsis thaliana.
  5. SUVH2 overexpression inhibits senescence-associated global changes in chromatin organization.
    Title: Epigenetic programming via histone methylation at WRKY53 controls leaf senescence in Arabidopsis thaliana.
  6. SRA-domain proteins (SUVH2) are also essential for DRM2-mediated de novo and maintenance DNA methylation in Arabidopsis thaliana.
    Title: SRA-domain proteins required for DRM2-mediated de novo DNA methylation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001336444.1
NM_001336446.1
NM_128889.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epigenetic regulation of gene expression TAS
Traceable Author Statement
more info
 PubMed 
involved_in gene silencing by siRNA-directed DNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
SU(VAR)3-9 homolog 2
NP_001318341.1
  • SU(VAR)3-9 homolog 2 (SUVH2); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), SRA-YDG (InterPro:IPR003105), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 9 (TAIR:AT4G13460.2); Has 2532 Blast hits to 2457 proteins in 202 species: Archae - 0; Bacteria - 14; Metazoa - 1497; Fungi - 199; Plants - 683; Viruses - 0; Other Eukaryotes - 139 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    14108529..14112464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336445.1 → NP_001324077.1  SU(VAR)3-9 homolog 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22781
    UniProtKB/TrEMBL
    A0A654EYF6

  2. NM_001336444.1 → NP_001318341.1  SU(VAR)3-9 homolog 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22781
    UniProtKB/TrEMBL
    A0A654EYF6

  3. NM_001336446.1 → NP_001324078.1  SU(VAR)3-9 homolog 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22781
    UniProtKB/TrEMBL
    A0A654EYF6

  4. NM_128889.3 → NP_180887.1  SU(VAR)3-9 homolog 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180887.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22781
    UniProtKB/TrEMBL
    A0A654EYF6
    Conserved Domains (3) summary
    smart00466
    Location:202 → 358
    SRA; SET and RING finger associated domain
    smart00317
    Location:495 → 642
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam05033
    Location:389 → 487
    Pre-SET; Pre-SET motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22781.1

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