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TCL1A TCL1 family AKT coactivator A [ Homo sapiens (human) ]

Gene ID: 8115, updated on 2-Nov-2024

Summary

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Official Symbol
TCL1Aprovided by HGNC
Official Full Name
TCL1 family AKT coactivator Aprovided by HGNC
Primary source
HGNC:HGNC:11648
See related
Ensembl:ENSG00000100721 MIM:186960; AllianceGenome:HGNC:11648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCL1
Summary
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Expression
Biased expression in lymph node (RPKM 72.1), spleen (RPKM 19.8) and 2 other tissues See more
Orthologs
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Genomic context

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See TCL1A in Genome Data Viewer
Location:
14q32.13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (95709947..95714125, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (89941532..89945710, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96176284..96180462, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene TCL1 family AKT coactivator B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8972 Neighboring gene uncharacterized LOC124903373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6050 Neighboring gene uncharacterized LOC107984703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8980 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96237254-96237437 Neighboring gene uncharacterized LOC105370644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia. Herling M, et al. Blood, 2008 Jan 1. PMID 17890451, Free PMC Article
  2. TCL1: a shared tumor-associated antigen for immunotherapy against B-cell lymphomas. Weng J, et al. Blood, 2012 Aug 23. PMID 22645177, Free PMC Article
  3. Recurrent breakpoints in 14q32.13/TCL1A region in mature B-cell neoplasms with villous lymphocytes. Urbankova H, et al. Leuk Lymphoma, 2012 Dec. PMID 22553924
  4. Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia. Sivina M, et al. Leukemia, 2012 Aug. PMID 22460735
  5. Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression. Liu M, et al. Breast Cancer Res, 2012 Mar 9. PMID 22405131, Free PMC Article

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation.
    Title: B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation.
  2. Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
    Title: Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
  3. TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.
    Title: TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.
  4. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
    Title: Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
  5. TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.
    Title: TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.
  6. Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.
    Title: Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.
  7. Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.
    Title: Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.
  8. TCL1A also acts as a transcriptional coregulator with NF-kappaB p65
    Title: TCL1A, a Novel Transcription Factor and a Coregulator of Nuclear Factor κB p65: Single Nucleotide Polymorphism and Estrogen Dependence.
  9. TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.
    Title: TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.
  10. Combination of T-cell lymphoma-1 protein (TCL1)-overexpression and damaging ataxia telangiectasia mutated protein (ATM) functionally synergistically contribute to T-cell prolymphocytic leukemia (T-PLL) specific phenotype of impaired DNA damage processing.
    Title: Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
Submit: New GeneRIF Correction See all GeneRIFs (69)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
T-cell leukemia/lymphoma protein 1A
Names
T cell leukemia/lymphoma 1A
T-cell lymphoma-1
oncogene TCL-1
oncogene TCL1
protein p14 TCL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098725.2 → NP_001092195.1  T-cell leukemia/lymphoma protein 1A

    See identical proteins and their annotated locations for NP_001092195.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL139020, BC014024, BG718395, X82240
    Consensus CDS
    CCDS9941.1
    UniProtKB/Swiss-Prot
    P56279, Q6IBK7
    Related
    ENSP00000451506.1, ENST00000554012.5
    Conserved Domains (1) summary
    pfam01840
    Location:1 → 112
    TCL1_MTCP1; TCL1/MTCP1 family

  2. NM_021966.3 → NP_068801.1  T-cell leukemia/lymphoma protein 1A

    See identical proteins and their annotated locations for NP_068801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AL139020, BC014024, BG718395, X82240
    Consensus CDS
    CCDS9941.1
    UniProtKB/Swiss-Prot
    P56279, Q6IBK7
    Related
    ENSP00000385036.1, ENST00000402399.6
    Conserved Domains (1) summary
    pfam01840
    Location:1 → 112
    TCL1_MTCP1; TCL1/MTCP1 family

RNA

  1. NR_049726.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL139020, BU602054, X82240

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    95709947..95714125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    89941532..89945710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56279.1 GenPept UniProtKB/Swiss-Prot:P56279

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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