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Conserved domains on  [gi|148922879|ref|NP_001092195|]
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T-cell leukemia/lymphoma protein 1A [Homo sapiens]

Protein Classification

TCL1_MTCP1 domain-containing protein( domain architecture ID 10486444)

TCL1_MTCP1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 1-112 3.70e-44

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


:

Pssm-ID: 460358  Cd Length: 118  Bit Score: 139.45  E-value: 3.70e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922879    1 MAECPTLgEAVTDHPDRLWAWEKFVYLDEKQHAWLPLTIEIKDRLQLRVLLRR-------EDVVLGRPMTPTQIGPSLLP 73
Cdd:pfam01840   1 MAEEASF-PHLPSPPDRLWIWRPGIYEDENGRTWLPVVVETSGSSRGWRIETQvtvhlwqMDVPPGEPMSPSQLTPSELP 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 148922879   74 IMWQLYPDGRYRSSDSSFWRLVYHIKIDGVEDMLLELLP 112
Cdd:pfam01840  80 LMWQLYPGNRYRASDSRFWRIVDHIQIDGTEQLILELMP 118
 
Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 1-112 3.70e-44

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


Pssm-ID: 460358  Cd Length: 118  Bit Score: 139.45  E-value: 3.70e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922879    1 MAECPTLgEAVTDHPDRLWAWEKFVYLDEKQHAWLPLTIEIKDRLQLRVLLRR-------EDVVLGRPMTPTQIGPSLLP 73
Cdd:pfam01840   1 MAEEASF-PHLPSPPDRLWIWRPGIYEDENGRTWLPVVVETSGSSRGWRIETQvtvhlwqMDVPPGEPMSPSQLTPSELP 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 148922879   74 IMWQLYPDGRYRSSDSSFWRLVYHIKIDGVEDMLLELLP 112
Cdd:pfam01840  80 LMWQLYPGNRYRASDSRFWRIVDHIQIDGTEQLILELMP 118
 
Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 1-112 3.70e-44

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


Pssm-ID: 460358  Cd Length: 118  Bit Score: 139.45  E-value: 3.70e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922879    1 MAECPTLgEAVTDHPDRLWAWEKFVYLDEKQHAWLPLTIEIKDRLQLRVLLRR-------EDVVLGRPMTPTQIGPSLLP 73
Cdd:pfam01840   1 MAEEASF-PHLPSPPDRLWIWRPGIYEDENGRTWLPVVVETSGSSRGWRIETQvtvhlwqMDVPPGEPMSPSQLTPSELP 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 148922879   74 IMWQLYPDGRYRSSDSSFWRLVYHIKIDGVEDMLLELLP 112
Cdd:pfam01840  80 LMWQLYPGNRYRASDSRFWRIVDHIQIDGTEQLILELMP 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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