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Ntng1 netrin G1 [ Mus musculus (house mouse) ]

Gene ID: 80883, updated on 2-Nov-2024

Summary

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Official Symbol
Ntng1provided by MGI
Official Full Name
netrin G1provided by MGI
Primary source
MGI:MGI:1934028
See related
Ensembl:ENSMUSG00000059857 AllianceGenome:MGI:1934028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmnt1; A930010C08Rik
Summary
Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including regulation of cell projection organization; regulation of neuron migration; and synaptic membrane adhesion. Acts upstream of or within axonogenesis. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. Is expressed in several structures, including brain and enteric nervous system. Orthologous to human NTNG1 (netrin G1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 3.3), whole brain E14.5 (RPKM 3.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Ntng1 in Genome Data Viewer
Location:
3 F3; 3 48.47 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (109687366..110057291, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (109780050..110149972, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zona pellucida binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:109144693-109144846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:109164872-109165133 Neighboring gene STARR-positive B cell enhancer mm9_chr3:109251268-109251568 Neighboring gene vav 3 oncogene Neighboring gene STARR-seq mESC enhancer starr_08700 Neighboring gene STARR-seq mESC enhancer starr_08701 Neighboring gene STARR-seq mESC enhancer starr_08702 Neighboring gene STARR-seq mESC enhancer starr_08703 Neighboring gene STARR-seq mESC enhancer starr_08704 Neighboring gene STARR-positive B cell enhancer ABC_E4578 Neighboring gene predicted gene, 25681 Neighboring gene predicted gene, 54214 Neighboring gene STARR-seq mESC enhancer starr_08706 Neighboring gene STARR-positive B cell enhancer mm9_chr3:110053793-110054094 Neighboring gene predicted gene 43405 Neighboring gene protein arginine N-methyltransferase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs. Meltzer S, et al. Proc Natl Acad Sci U S A, 2022 Oct 25. PMID 36252008, Free PMC Article
  2. Somatosensory cortical signature of facial nociception and vibrotactile touch-induced analgesia. Lu J, et al. Sci Adv, 2022 Nov 18. PMID 36383651, Free PMC Article
  3. Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits. Zhang Q, et al. Sci Rep, 2016 Jun 27. PMID 27345935, Free PMC Article
  4. Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence. Kelaï S, et al. Addict Biol, 2018 Jan. PMID 28074533
  5. Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins. Zhang Q, et al. Mol Brain, 2016 Jan 8. PMID 26746425, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs.
    Title: A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs.
  2. Decreased Ntng1 expression was initially observed in the nucleus accumbens of mice conditioned to cocaine.
    Title: Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence.
  3. findings support a crucial role for netrin-G1 in dissociable neural circuits for the modulation of emotion-related behaviors, and provide genetic models for investigating the mechanisms underlying the dissociation.
    Title: Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits.
  4. Pre-synaptic netrin-G1 and netrin-G2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties.
    Title: Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.
  5. netrin-G/NGL interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
    Title: Netrin-G/NGL complexes encode functional synaptic diversification.
  6. The complementary expression patterns of Ntng1 and Ntng2 are determined by transcriptional cis-regulatory elements widely scattered in these loci.
    Title: Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice.
  7. selectively expressed in distinct neuronal subsets that include populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia
    Title: Laminets: laminin- and netrin-related genes expressed in distinct neuronal subsets.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC99878

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables cell-cell adhesion mediator activity IEA
Inferred from Electronic Annotation
more info
  
enables cell-cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron projection arborization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic membrane adhesion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
netrin-G1
Names
laminet-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163348.1 → NP_001156820.1  netrin-G1 isoform b

    See identical proteins and their annotated locations for NP_001156820.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) lacks an alternate in-frame exon compared to variant a. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB038666, AB038667, AK034465, BB621591, BC079881
    Consensus CDS
    CCDS59652.1
    UniProtKB/TrEMBL
    F8WJ48
    Related
    ENSMUSP00000120688.3, ENSMUST00000138344.9
    Conserved Domains (3) summary
    smart00180
    Location:364 → 411
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  2. NM_001163349.1 → NP_001156821.1  netrin-G1 isoform c

    See identical proteins and their annotated locations for NP_001156821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) lacks two alternate in-frame exons compared to variant a. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB038665, AB038667, AK034465, BB621591, BC079881
    Consensus CDS
    CCDS59651.1
    UniProtKB/TrEMBL
    F8WJ50
    Related
    ENSMUSP00000117371.3, ENSMUST00000133268.9
    Conserved Domains (3) summary
    cd00054
    Location:373 → 397
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  3. NM_001163350.1 → NP_001156822.1  netrin-G1 isoform d

    See identical proteins and their annotated locations for NP_001156822.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) lacks two alternate in-frame exons and contains two other alternate in-frame exons compared to variant a. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB038664, AB038667, AK034465, BB621591, BC079881
    Consensus CDS
    CCDS59654.1
    UniProtKB/TrEMBL
    F8WJ50
    Related
    ENSMUSP00000116213.3, ENSMUST00000138953.9
    Conserved Domains (3) summary
    cd00054
    Location:415 → 439
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  4. NM_030699.2 → NP_109624.1  netrin-G1 isoform a precursor

    See identical proteins and their annotated locations for NP_109624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB038667, AK034465, BB621591
    Consensus CDS
    CCDS38604.1
    UniProtKB/Swiss-Prot
    Q68FE5, Q69ZU3, Q8R4F3, Q8R4F4, Q8R4F5, Q8R4F6, Q8R4F7, Q8R4F8, Q8R4F9, Q8R4G0, Q9ESR3, Q9ESR4, Q9ESR5, Q9ESR6, Q9ESR7, Q9ESR8
    UniProtKB/TrEMBL
    F8WJ48
    Related
    ENSMUSP00000072397.6, ENSMUST00000072596.12
    Conserved Domains (3) summary
    smart00180
    Location:420 → 467
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  5. NM_133488.1 → NP_597995.1  netrin-G1 isoform e precursor

    See identical proteins and their annotated locations for NP_597995.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) lacks two alternate in-frame exons and contains another alternate in-frame exon compared to variant a. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB038663, AB038667, AK034465, BB621591, BC079881
    Consensus CDS
    CCDS59653.1
    UniProtKB/TrEMBL
    F8WJ50
    Related
    ENSMUSP00000119534.3, ENSMUST00000156177.9
    Conserved Domains (3) summary
    cd00054
    Location:395 → 419
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    109687366..110057291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240295.4 → XP_011238597.1  netrin-G1 isoform X5

    UniProtKB/TrEMBL
    F8WJ48
    Related
    ENSMUSP00000118800.3, ENSMUST00000131027.9
    Conserved Domains (2) summary
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  2. XM_011240294.4 → XP_011238596.1  netrin-G1 isoform X4

    UniProtKB/TrEMBL
    F8WJ48
    Conserved Domains (3) summary
    smart00180
    Location:386 → 433
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  3. XM_011240293.4 → XP_011238595.1  netrin-G1 isoform X3

    UniProtKB/TrEMBL
    F8WJ50
    Conserved Domains (3) summary
    smart00180
    Location:406 → 453
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  4. XM_011240292.4 → XP_011238594.1  netrin-G1 isoform X2

    UniProtKB/TrEMBL
    F8WJ50
    Conserved Domains (3) summary
    cd00054
    Location:471 → 495
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  5. XM_011240291.4 → XP_011238593.1  netrin-G1 isoform X1

    See identical proteins and their annotated locations for XP_011238593.1

    UniProtKB/TrEMBL
    F8WJ48
    Conserved Domains (3) summary
    smart00180
    Location:462 → 509
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  6. XM_006502355.5 → XP_006502418.1  netrin-G1 isoform X1

    See identical proteins and their annotated locations for XP_006502418.1

    UniProtKB/TrEMBL
    F8WJ48
    Conserved Domains (3) summary
    smart00180
    Location:462 → 509
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

RNA

  1. XR_001783784.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001163351.1: Suppressed sequence

    Description
    NM_001163351.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4G0.2 GenPept UniProtKB/Swiss-Prot:Q8R4G0

Gene LinkOut

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