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naxd NAD(P)HX dehydratase [ Danio rerio (zebrafish) ]

Gene ID: 797867, updated on 17-Aug-2024

Summary

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Official Symbol
naxdprovided by ZNC
Official Full Name
NAD(P)HX dehydrataseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080204-1
See related
Ensembl:ENSDARG00000077119 AllianceGenome:ZFIN:ZDB-GENE-080204-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
carkd; zgc:171429
Summary
Predicted to enable ADP-dependent NAD(P)H-hydrate dehydratase activity; ATP binding activity; and ATP-dependent NAD(P)H-hydrate dehydratase activity. Predicted to be involved in nicotinamide nucleotide metabolic process. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See naxd in Genome Data Viewer
Location:
chromosome: 9
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (8897881..8923471)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (8919435..8945141)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 2 Neighboring gene RAB20, member RAS oncogene family Neighboring gene ankyrin repeat domain 10b Neighboring gene ubiquitin conjugating enzyme E2 A, like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC171429

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent NAD(P)H-hydrate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nicotinamide nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
Names
carbohydrate kinase domain containing
NP_001315079.1
XP_005167513.1
XP_005167514.1
XP_005167516.1
XP_005167517.1
XP_005167519.1
XP_005167520.1
XP_005167521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110120.2 → NP_001103590.2  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX539345
    UniProtKB/TrEMBL
    A8KB11
    Related
    ENSDARP00000102965.4, ENSDART00000111214.4

  2. NM_001328150.1 → NP_001315079.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 1

    Status: PROVISIONAL

    Source sequence(s)
    BX539345
    UniProtKB/TrEMBL
    A0A8M1P3L1, E7F490
    Related
    ENSDARP00000107908.3, ENSDART00000130208.3
    Conserved Domains (2) summary
    cd01171
    Location:347 → 615
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
    pfam13837
    Location:11 → 94
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    8897881..8923471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167460.4 → XP_005167517.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X4

    UniProtKB/TrEMBL
    A0A8M2BFH6, A8KB11
    Conserved Domains (1) summary
    cd01171
    Location:202 → 470
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

  2. XM_005167462.4 → XP_005167519.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X5

    UniProtKB/TrEMBL
    A0A8M2BEY3, A8KB11
    Conserved Domains (1) summary
    cd01171
    Location:192 → 460
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

  3. XM_005167463.4 → XP_005167520.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X6

    UniProtKB/TrEMBL
    A0A8M2BEU7
    Conserved Domains (1) summary
    cd01171
    Location:58 → 326
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

  4. XM_005167464.4 → XP_005167521.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X7

    See identical proteins and their annotated locations for XP_005167521.1

    UniProtKB/Swiss-Prot
    F1Q575
    Related
    ENSDARP00000123516.1, ENSDART00000147098.3
    Conserved Domains (1) summary
    cd01171
    Location:52 → 320
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

  5. XM_005167459.2 → XP_005167516.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X3

    UniProtKB/TrEMBL
    A0A8M2BET0, A8KB11
    Conserved Domains (1) summary
    cd01171
    Location:204 → 472
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

  6. XM_005167456.4 → XP_005167513.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X1

    UniProtKB/TrEMBL
    A0A8M2BEU4
    Conserved Domains (2) summary
    cd01171
    Location:343 → 611
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
    pfam13837
    Location:11 → 94
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  7. XM_005167457.4 → XP_005167514.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X2

    UniProtKB/TrEMBL
    A0A8M2BEW7
    Conserved Domains (2) summary
    cd01171
    Location:337 → 605
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
    pfam13837
    Location:11 → 94
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1Q575.1 GenPept UniProtKB/Swiss-Prot:F1Q575

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