U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plppr5 phospholipid phosphatase related 5 [ Mus musculus (house mouse) ]

Gene ID: 75769, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Plppr5provided by MGI
Official Full Name
phospholipid phosphatase related 5provided by MGI
Primary source
MGI:MGI:1923019
See related
Ensembl:ENSMUSG00000033342 AllianceGenome:MGI:1923019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lppr5; PRG-5; Pap2d; 4833424O15Rik
Summary
Predicted to enable phosphatidate phosphatase activity. Involved in positive regulation of filopodium assembly and positive regulation of neuron projection development. Located in plasma membrane. Is expressed in brain and cerebellum. Orthologous to human PLPPR5 (phospholipid phosphatase related 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 3.1), CNS E18 (RPKM 1.7) and 5 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Plppr5 in Genome Data Viewer
Location:
3 G1; 3 51.21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (117368274..117483157)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (117574608..117689508)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32216 Neighboring gene predicted gene, 40130 Neighboring gene STARR-seq mESC enhancer starr_08803 Neighboring gene STARR-seq mESC enhancer starr_08804 Neighboring gene phospholipid phosphatase related 4 Neighboring gene STARR-seq mESC enhancer starr_08806 Neighboring gene STARR-seq mESC enhancer starr_08807 Neighboring gene STARR-seq mESC enhancer starr_08808 Neighboring gene sorting nexin 7 Neighboring gene STARR-seq mESC enhancer starr_08809 Neighboring gene predicted gene, 52614 Neighboring gene STARR-seq mESC enhancer starr_08810 Neighboring gene predicted gene, 32344

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Plppr5 gene inactivation causes a more severe neurological phenotype and abnormal mitochondrial homeostasis in a mouse model of juvenile seizure. Wang D, et al. Epilepsy Res, 2022 Jul. PMID 35617916
  2. Plasticity-related gene 5 promotes spine formation in murine hippocampal neurons. Coiro P, et al. J Biol Chem, 2014 Sep 5. PMID 25074937, Free PMC Article
  3. Genetic Inhibition of Plppr5 Aggravates Hypoxic-Ischemie-Induced Cortical Damage and Excitotoxic Phenotype. Sun Y, et al. Front Neurosci, 2022. PMID 35401091, Free PMC Article
  4. Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice. Sun Y, et al. Front Endocrinol (Lausanne), 2021. PMID 33692754, Free PMC Article
  5. PRG5 Knockout Precipitates Late-Onset Hypersusceptibility to Pilocarpine-Induced Juvenile Seizures by Exacerbating Hippocampal Zinc Signaling-Mediated Mitochondrial Damage. Wang D, et al. Front Neurosci, 2021. PMID 34512249, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice.
    Title: Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice.
  2. Data indicate that plasticity-related genes 5 (PRG5) expression is involved in proper spine formation.
    Title: Plasticity-related gene 5 promotes spine formation in murine hippocampal neurons.
  3. Data show that PRG5 induces filopodia growth independently of Cdc42, and that axon collapse and RhoA activation induced by LPA and myelin-associated neurite inhibitor Nogo-A is attenuated in the presence of PRG5.
    Title: Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
phospholipid phosphatase-related protein type 5
Names
lipid phosphate phosphatase-related protein type 5
phosphatidic acid phosphatase type 2d
plasticity-related gene 5 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305451.1 → NP_001292380.1  phospholipid phosphatase-related protein type 5 isoform 1

    See identical proteins and their annotated locations for NP_001292380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC116774, AC122030, AK032034, AK076176
    Consensus CDS
    CCDS80009.1
    UniProtKB/Swiss-Prot
    Q8BIL7, Q8BJ52, Q8K0B6, Q9D606
    UniProtKB/TrEMBL
    A0A5F8MPS1
    Related
    ENSMUSP00000102081.3, ENSMUST00000106473.5
    Conserved Domains (1) summary
    cd03384
    Location:118 → 267
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  2. NM_029425.3 → NP_083701.2  phospholipid phosphatase-related protein type 5 isoform 2

    See identical proteins and their annotated locations for NP_083701.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC122030, AK014763, AK043629, BB351291, BB611685, BB622243, CB722774
    Consensus CDS
    CCDS17796.1
    UniProtKB/TrEMBL
    A0A5F8MPS1
    Related
    ENSMUSP00000045121.7, ENSMUST00000039564.11
    Conserved Domains (1) summary
    cd03384
    Location:118 → 267
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    117368274..117483157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163380.1 → XP_036019273.1  phospholipid phosphatase-related protein type 5 isoform X3

    Conserved Domains (1) summary
    cl00474
    Location:118 → 207
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

  2. XM_036163381.1 → XP_036019274.1  phospholipid phosphatase-related protein type 5 isoform X4

    Conserved Domains (1) summary
    cl00474
    Location:118 → 208
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

  3. XM_036163382.1 → XP_036019275.1  phospholipid phosphatase-related protein type 5 isoform X5

    Conserved Domains (1) summary
    cl00474
    Location:118 → 207
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

  4. XM_036163379.1 → XP_036019272.1  phospholipid phosphatase-related protein type 5 isoform X2

    Conserved Domains (1) summary
    cd03384
    Location:118 → 266
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  5. XM_036163378.1 → XP_036019271.1  phospholipid phosphatase-related protein type 5 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MPS1
    Conserved Domains (1) summary
    cd03384
    Location:118 → 267
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ52.1 GenPept UniProtKB/Swiss-Prot:Q8BJ52

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous