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Conserved domains on  [gi|1907152412|ref|XP_036019271|]
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phospholipid phosphatase-related protein type 5 isoform X1 [Mus musculus]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
118-267 4.61e-72

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 219.42  E-value: 4.61e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 118 RTVRFLGIYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAA 197
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 198 LSVYAATYLTMYITSTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 267
Cdd:cd03384    81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
118-267 4.61e-72

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 219.42  E-value: 4.61e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 118 RTVRFLGIYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAA 197
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 198 LSVYAATYLTMYITSTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 267
Cdd:cd03384    81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
125-272 1.48e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 68.99  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 125 IYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTAlGCQQYTQFISgeeactgnpdlimrarktFPSKEAALSVYAAT 204
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPA-PSTLPGLGYS------------------FPSGHSATAFALAL 61
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152412 205 YLTMYITSTIKAKgtrlaKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVN 272
Cdd:pfam01569  62 LLALLLRRLRKIV-----RVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PLN02715 PLN02715
lipid phosphate phosphatase
128-265 1.78e-13

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 69.70  E-value: 1.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 128 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNytalGCQQYTQFisGEEACTGNPDLIMRARKTFPSKEAALSVYAATYLT 207
Cdd:PLN02715  130 FAVLITGVITDSIKVATGRPRPNFYWRCFPD----GKELYDAL--GGVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLS 203
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 208 MYITSTIKAKGTRLAKPVLCLGLMCL--AFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 265
Cdd:PLN02715  204 LYLSGKIKAFNGEGHVAKLCLVIFPLlaACLVGISRVDDYWHHWQDVFAGALIGILVAAF 263
acidPPc smart00014
Acid phosphatase homologues;
127-267 4.76e-13

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 64.67  E-value: 4.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412  127 AFGLFATDIFVNAGQVVTGNLAPHFLALCKPnytalgcqqytqfisgeeACTGNPDLIMRARKTFPSKEAALSVYAATYL 206
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA------------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFL 62
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907152412  207 TMYItstikakGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 267
Cdd:smart00014  63 LLYL-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
191-267 7.29e-04

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 40.02  E-value: 7.29e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152412 191 FPSKEAALSVYAATYLTMYitstikakgtrLAKPVLCLGLMCLAFLTGLNRVaeYRN-HW-SDVIAGFLVGISIAVFLV 267
Cdd:COG0671   119 FPSGHAAAAFALALVLALL-----------LPRRWLAALLLALALLVGLSRV--YLGvHYpSDVLAGALLGLAIALLLL 184
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
118-267 4.61e-72

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 219.42  E-value: 4.61e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 118 RTVRFLGIYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAA 197
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 198 LSVYAATYLTMYITSTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 267
Cdd:cd03384    81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
49-265 9.73e-22

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 90.36  E-value: 9.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412  49 AYRKPYPgpeDSSAVPPVLLYSLAAGVPVLVIIVgetavFCLqLATRDFENQEKTILTgdccyinplvrrtvrFLGIYAF 128
Cdd:cd03390     2 SISYPFA---ESETVPTWLLVIISVGIPLLVIIL-----ISL-FFRRSLWDLHTSLLG---------------LLLSVSL 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 129 GLFATDIFVNAgqvvTGNLAPHFLALCKPNYTALGCQQYTqfisGEEACTGNPDLIMRARKTFPSKEAALSVYAATYLTM 208
Cdd:cd03390    58 NGVITNVLKNY----AGRPRPDFLARCFPDGGTPSDTLVG----IDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSL 129
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152412 209 YITS--TIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 265
Cdd:cd03390   130 YLAGklHIFDPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYL 188
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
125-272 1.48e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 68.99  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 125 IYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTAlGCQQYTQFISgeeactgnpdlimrarktFPSKEAALSVYAAT 204
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPA-PSTLPGLGYS------------------FPSGHSATAFALAL 61
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152412 205 YLTMYITSTIKAKgtrlaKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVN 272
Cdd:pfam01569  62 LLALLLRRLRKIV-----RVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
120-267 1.73e-14

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 68.64  E-value: 1.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 120 VRFLGIYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYtalgcqqytqfisgeeactgNPDLIMRARKTFPSKEAALS 199
Cdd:cd01610     2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDG--------------------DPLLLTEGGYSFPSGHAAFA 61
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152412 200 VYAATYLTMYITStikakgtRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 267
Cdd:cd01610    62 FALALFLALLLPR-------RLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PLN02715 PLN02715
lipid phosphate phosphatase
128-265 1.78e-13

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 69.70  E-value: 1.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 128 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNytalGCQQYTQFisGEEACTGNPDLIMRARKTFPSKEAALSVYAATYLT 207
Cdd:PLN02715  130 FAVLITGVITDSIKVATGRPRPNFYWRCFPD----GKELYDAL--GGVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLS 203
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 208 MYITSTIKAKGTRLAKPVLCLGLMCL--AFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 265
Cdd:PLN02715  204 LYLSGKIKAFNGEGHVAKLCLVIFPLlaACLVGISRVDDYWHHWQDVFAGALIGILVAAF 263
acidPPc smart00014
Acid phosphatase homologues;
127-267 4.76e-13

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 64.67  E-value: 4.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412  127 AFGLFATDIFVNAGQVVTGNLAPHFLALCKPnytalgcqqytqfisgeeACTGNPDLIMRARKTFPSKEAALSVYAATYL 206
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA------------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFL 62
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907152412  207 TMYItstikakGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 267
Cdd:smart00014  63 LLYL-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
128-265 5.05e-13

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 68.41  E-value: 5.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 128 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALgcqqyTQFISGEEACTGNPDLIMRARKTFPSKEAALSVYAATYLT 207
Cdd:PLN02250  105 FSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV-----FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLS 179
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 208 MYITSTIKAKGTRLAKPVLCLGLMCL--AFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 265
Cdd:PLN02250  180 LYLSGKIRVFDRRGHVAKLCIVFLPLlvAALVGVSRVDDYWHHWQDVFAGALIGLTVASF 239
PLN02731 PLN02731
Putative lipid phosphate phosphatase
128-260 3.06e-11

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 63.12  E-value: 3.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152412 128 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALgcqqYTQFisGEEACTGNPDLIMRARKTFPSKEAALSVYAATYLT 207
Cdd:PLN02731  124 YSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKAL----YDSL--GDVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLS 197
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907152412 208 MYITSTIKAKGTRLAKPVLCLGLMCLAF--LTGLNRVAEYRNHWSDVIAGFLVGI 260
Cdd:PLN02731  198 LYLSGKIQAFDGKGHVAKLCIVILPLLFaaLVGISRVDDYWHHWQDVFAGGLLGL 252
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
191-266 9.26e-05

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 42.60  E-value: 9.26e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152412 191 FPSKEAALSVYAATYLTMYITSTIKAKGTRLAKPVLCLGLmclAFLTGLNRVaeYRN-HW-SDVIAGFLVGISIAVFL 266
Cdd:cd03392   103 FPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAIL---ILLVGLSRL--YLGvHYpSDVLAGWLLGLAWLALL 175
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
191-267 7.29e-04

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 40.02  E-value: 7.29e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152412 191 FPSKEAALSVYAATYLTMYitstikakgtrLAKPVLCLGLMCLAFLTGLNRVaeYRN-HW-SDVIAGFLVGISIAVFLV 267
Cdd:COG0671   119 FPSGHAAAAFALALVLALL-----------LPRRWLAALLLALALLVGLSRV--YLGvHYpSDVLAGALLGLAIALLLL 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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