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smarcal1.L SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734728, updated on 17-Aug-2024

Summary

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Official Symbol
smarcal1.L
Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 L homeolog
Primary source
Xenbase:XB-GENE-866253
Locus tag
XELAEV_18044415mg
See related
EnsemblRapid:ENSXLAG00005017273
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
harp; smarcal1
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Genomic context

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Location:
chromosome: 9_10L
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (59543811..59564984)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (48939876..48961224)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog Neighboring gene membrane associated ring-CH-type finger 4 L homeolog Neighboring gene uncharacterized protein MGC147242 L homeolog Neighboring gene insulin-like growth factor-binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments. Kolinjivadi AM, et al. Mol Cell, 2017 Sep 7. PMID 28757209, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brca2 and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 and Mre11 predisposes to genome instability.
    Title: Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC115661

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA/DNA annealing activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Names
Sucrose nonfermenting protein 2-like 1
hepA-related protein
NP_001089668.1
XP_018090083.1
XP_018090084.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096199.1 → NP_001089668.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

    See identical proteins and their annotated locations for NP_001089668.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100245
    UniProtKB/Swiss-Prot
    Q498E7
    Related
    ENSXLAP00005050957.1, ENSXLAT00005052119.1
    Conserved Domains (4) summary
    COG0553
    Location:406 → 877
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00046
    Location:475 → 603
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:733 → 843
    Helicase_C; Helicase conserved C-terminal domain
    pfam07443
    Location:365 → 418
    HARP; HepA-related protein (HARP)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    59543811..59564984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018234594.2 → XP_018090083.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A1L8EVE4, A0A974H3Q6

  2. XM_018234595.2 → XP_018090084.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A1L8EVE4, A0A974H3Q6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q498E7.1 GenPept UniProtKB/Swiss-Prot:Q498E7

Gene LinkOut

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