axin1.S axin 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: axin1.S
Official Full Name: axin 1 S homeolog
Primary source: Xenbase:XB-GENE-865645
Locus tag: XELAEV_18047809mg
See related: EnsemblRapid:ENSXLAG00005009234
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: axin; axin1; fused; xAxin
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (106864147..106907628)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (100225346..100268744)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation
Title: Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein kinase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: axin 1 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001095782.1 → NP_001089251.1 axin 1 S homeolog

See identical proteins and their annotated locations for NP_001089251.1

Status: PROVISIONAL

Source sequence(s)

BC089276

UniProtKB/TrEMBL

A0A974BVW4, Q5FWN0

Related

ENSXLAP00005026898.1, ENSXLAT00005027631.1

Conserved Domains (4) summary

cd08707
Location:89 → 209

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

cd11582
Location:11 → 80

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam00778
Location:795 → 870

DIX; DIX domain

pfam08833
Location:464 → 499

Axin_b-cat_bind; Axin beta-catenin binding domain