Tmem138 transmembrane protein 138 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem138provided by MGI
Official Full Name: transmembrane protein 138provided by MGI
Primary source: MGI:MGI:1920232
See related: Ensembl:ENSMUSG00000024666 AllianceGenome:MGI:1920232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700113I01Rik; 2900055D14Rik
Summary: Predicted to be involved in cilium assembly. Predicted to be located in vacuolar membrane. Predicted to be active in cilium. Is expressed in several structures, including 4th ventricle choroid plexus; brain ventricular layer; choroid invagination; genitourinary system; and gut gland. Human ortholog(s) of this gene implicated in Joubert syndrome 16. Orthologous to human TMEM138 (transmembrane protein 138). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 6.9), CNS E11.5 (RPKM 6.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.6 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10547842..10554765, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10570478..10577386, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487951

NoName (e-PCR)
- UniSTS:237896

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 138

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302218.1 → NP_001289147.1 transmembrane protein 138 isoform 2

See identical proteins and their annotated locations for NP_001289147.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a downstream alternate 5'-terminal exon and includes an upstream alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC125093, AK007197

UniProtKB/Swiss-Prot

Q9D6G5

Related

ENSMUST00000236958.2

Conserved Domains (1) summary

pfam14935
Location:38 → 100

TMEM138; Transmembrane protein 138
NM_028411.4 → NP_082687.1 transmembrane protein 138 isoform 1

See identical proteins and their annotated locations for NP_082687.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AA030680, AC125093, AK031921, AK050471

Consensus CDS

CCDS29581.1

UniProtKB/Swiss-Prot

Q9D6G5, Q9D9A8

Related

ENSMUSP00000025568.3, ENSMUST00000025568.3

Conserved Domains (1) summary

pfam14935
Location:38 → 156

TMEM138; Transmembrane protein 138

RNA

NR_126092.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the central region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AA030680, AC125093, AK031921, AK050471

Related

ENSMUST00000235990.2