DHX8 DEAH-box helicase 8 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: DHX8provided by VGNC
Official Full Name: DEAH-box helicase 8provided by VGNC
Primary source: VGNC:VGNC:71765
See related: Ensembl:ENSMMUG00000012071
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	16	NC_041769.1 (54719245..54763554)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	16	NC_027908.1 (49265188..49309363)

Chromosome 16 - NC_041769.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D17S1212 (e-PCR)
- UniSTS:56073

D17S1234 (e-PCR)
- UniSTS:149847

DHX8__4735 (e-PCR)
- UniSTS:468380

SHGC-148771 (e-PCR)
- UniSTS:176598

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info	PubMed
involved_in spliceosomal complex disassembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in intracellular anatomical structure	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ATP-dependent RNA helicase DHX8

XP_014975300.1

EC 3.6.1.-

EC 3.6.4.13

XP_014975301.1

EC 3.6.1.-

EC 3.6.4.13

XP_028692373.1

EC 3.6.1.-

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041769.1 Reference Mmul_10 Primary Assembly

Range

54719245..54763554

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015119814.2 → XP_014975300.1 ATP-dependent RNA helicase DHX8 isoform X1

UniProtKB/TrEMBL

A0A1D5QP06, G7NIV0

Related

ENSMMUP00000049783.2, ENSMMUT00000077894.2

Conserved Domains (6) summary

smart00487
Location:563 → 748

DEXDc; DEAD-like helicases superfamily

smart00847
Location:966 → 1048

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:584 → 722

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd00079
Location:747 → 904

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd05684
Location:267 → 345

S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...

pfam07717
Location:1082 → 1181

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
XM_015119815.2 → XP_014975301.1 ATP-dependent RNA helicase DHX8 isoform X3

UniProtKB/TrEMBL

G7NIV0

Conserved Domains (6) summary

smart00487
Location:563 → 748

DEXDc; DEAD-like helicases superfamily

smart00847
Location:966 → 1048

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:584 → 722

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd00079
Location:747 → 904

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd05684
Location:267 → 345

S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...

pfam07717
Location:1082 → 1151

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
XM_028836540.1 → XP_028692373.1 ATP-dependent RNA helicase DHX8 isoform X2

UniProtKB/TrEMBL

G7NIV0

Conserved Domains (3) summary

COG0539
Location:263 → 422

RpsA; Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]

COG1643
Location:557 → 1219

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

cd05684
Location:265 → 343

S1_DHX8_helicase; The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced mRNA by releasing ...