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C8g complement component 8, gamma polypeptide [ Mus musculus (house mouse) ]

Gene ID: 69379, updated on 28-Oct-2024

Summary

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Official Symbol
C8gprovided by MGI
Official Full Name
complement component 8, gamma polypeptideprovided by MGI
Primary source
MGI:MGI:88237
See related
Ensembl:ENSMUSG00000015083 AllianceGenome:MGI:88237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a secreted protein that is a core component of the complement 8 (C8) complex. C8 is part of the membrane attack complex which participates in the innate immune response against bacterial pathogens. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Expression
Biased expression in liver adult (RPKM 279.9), liver E18 (RPKM 36.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See C8g in Genome Data Viewer
Location:
2 A3; 2 17.31 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25388662..25391731, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25498650..25501777, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35287 Neighboring gene lipocalin 12 Neighboring gene STARR-positive B cell enhancer ABC_E9193 Neighboring gene F-box and WD-40 domain protein 5 Neighboring gene TNF receptor-associated factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E273 Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25404685-25404887 Neighboring gene STARR-positive B cell enhancer ABC_E11127 Neighboring gene predicted gene, 35476

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human complement protein C8 gamma. Schreck SF, et al. Biochim Biophys Acta, 2000 Oct 18. PMID 11058761
  2. Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit. Slade DJ, et al. J Mol Biol, 2008 May 30. PMID 18440555, Free PMC Article
  3. International Colloquium on beta-trace. Osaka, Japan, November 17, 1995. Abstracts. . Prostaglandins, 1996 Apr. PMID 8966221
  4. Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain. Musingarimi P, et al. Biochemistry, 2002 Sep 17. PMID 12220191
  5. Role of the human C8 subunits in complement-mediated bacterial killing: evidence that C8 gamma is not essential. Parker CL, et al. Mol Immunol, 2002 Nov. PMID 12413696

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A review of the human C8 gamma ortholog.
    Title: Human complement protein C8 gamma.
  2. This is a study of the human C8 orthologs. Binding of C8 gamma subunit to C8 beta is dependent on the thrombospondin type 1 module, low-density lipoprotein receptor class A module, and membrane attack complex/perforin domain of C8 beta.
    Title: Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain.
  3. This is a study of the human orthologs of C8 alpha, beta, and gamma. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria.
    Title: Role of the human C8 subunits in complement-mediated bacterial killing: evidence that C8 gamma is not essential.
  4. Results describe the crystal structure of the human ortholog C8 alpha MACPF domain disulfide-linked to C8 gamma (alphaMACPF-gamma) at 2.15 A resolution.
    Title: Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables complement binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables complement binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables retinol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of immune response NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of membrane attack complex ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
complement component C8 gamma chain
Names
complement component 8, gamma subunit
novel lipocalin protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271777.1 → NP_001258706.1  complement component C8 gamma chain isoform 2

    See identical proteins and their annotated locations for NP_001258706.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK005962, AL732557
    Consensus CDS
    CCDS71001.1
    UniProtKB/TrEMBL
    Q9DAC2
    Related
    ENSMUSP00000015227.4, ENSMUST00000015227.4
    Conserved Domains (1) summary
    pfam00061
    Location:14 → 150
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  2. NM_001421917.1 → NP_001408846.1  complement component C8 gamma chain isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL732557

  3. NM_001421918.1 → NP_001408847.1  complement component C8 gamma chain isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL732557

  4. NM_001421919.1 → NP_001408848.1  complement component C8 gamma chain isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL732557

  5. NM_027062.3 → NP_081338.1  complement component C8 gamma chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_081338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL732557
    Consensus CDS
    CCDS15777.1
    UniProtKB/Swiss-Prot
    Q8VCG4
    Related
    ENSMUSP00000041855.5, ENSMUST00000040042.11
    Conserved Domains (1) summary
    pfam00061
    Location:48 → 184
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25388662..25391731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCG4.1 GenPept UniProtKB/Swiss-Prot:Q8VCG4

Gene LinkOut

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