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Bcas2 BCAS2 pre-mRNA processing factor [ Mus musculus (house mouse) ]

Gene ID: 68183, updated on 2-Nov-2024

Summary

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Official Symbol
Bcas2provided by MGI
Official Full Name
BCAS2 pre-mRNA processing factorprovided by MGI
Primary source
MGI:MGI:1915433
See related
Ensembl:ENSMUSG00000005687 AllianceGenome:MGI:1915433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6430539P16Rik
Summary
Acts upstream of or within several processes, including alternative mRNA splicing, via spliceosome; ovarian follicle development; and spindle assembly. Part of Prp19 complex. Is expressed in several structures, including central nervous system; early conceptus; oocyte; peripheral nervous system ganglion; and submandibular gland primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 58.9), liver E14.5 (RPKM 49.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Bcas2 in Genome Data Viewer
Location:
3 F2.2; 3 45.25 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103078971..103086479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103171655..103179163)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08585 Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene STARR-seq mESC enhancer starr_08586 Neighboring gene DENN domain containing 2C Neighboring gene STARR-seq mESC enhancer starr_08590 Neighboring gene STARR-seq mESC enhancer starr_08592 Neighboring gene STARR-positive B cell enhancer mm9_chr3:102975364-102975665 Neighboring gene STARR-seq mESC enhancer starr_08594 Neighboring gene STARR-seq mESC enhancer starr_08595 Neighboring gene STARR-seq mESC enhancer starr_08596 Neighboring gene STARR-positive B cell enhancer mm9_chr3:103010366-103010667 Neighboring gene STARR-seq mESC enhancer starr_08597 Neighboring gene predicted gene, 40113 Neighboring gene STARR-seq mESC enhancer starr_08598 Neighboring gene STARR-positive B cell enhancer mm9_chr3:103082888-103083189 Neighboring gene tripartite motif-containing 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice. Chen X, et al. Endocrinology, 2023 Nov 20. PMID 37820033
  2. Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via β-catenin. Chen HH, et al. Stem Cell Res Ther, 2022 Apr 11. PMID 35410459, Free PMC Article
  3. Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via β-catenin. Huang CW, et al. Sci Rep, 2016 Oct 7. PMID 27713508, Free PMC Article
  4. BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing. Yao X, et al. J Ovarian Res, 2023 May 29. PMID 37248466, Free PMC Article
  5. Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells. Lee S, et al. Cancer Lett, 2002 Dec 15. PMID 12406557

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing.
    Title: BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing.
  2. BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice.
    Title: BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice.
  3. BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing.
    Title: BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing.
  4. Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via beta-catenin.
    Title: Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via β-catenin.
  5. BCAS2 is involved in alternative splicing and mouse oocyte development.
    Title: BCAS2 is involved in alternative splicing and mouse oocyte development.
  6. Study results suggest that Bcas2 regulates alternative splicing in spermatogonia and the transition to meiosis initiation, and male fertility.
    Title: BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis.
  7. BCAS2 is an upstream regulator of beta-catenin gene expression and plays a role in dendrite growth at least partly through beta-catenin in the forebrain.
    Title: Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via β-catenin.
  8. BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
    Title: BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
  9. Maternal BCAS2 protects genomic integrity in mouse early embryonic development.
    Title: Maternal BCAS2 protects genomic integrity in mouse early embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7712

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within oocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
  
part_of DNA replication factor A complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Prp19 complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of Prp19 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Prp19 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type catalytic step 2 spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pre-mRNA-splicing factor SPF27
Names
DNA amplified in mammary carcinoma 1 protein
breast carcinoma amplified sequence 2
breast carcinoma-amplified sequence 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356330.1 → NP_001343259.1  pre-mRNA-splicing factor SPF27 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC150894
    UniProtKB/TrEMBL
    Q3U5M2
    Conserved Domains (1) summary
    pfam05700
    Location:11 → 197
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

  2. NM_001356331.1 → NP_001343260.1  pre-mRNA-splicing factor SPF27 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC150894
    UniProtKB/TrEMBL
    Q05CL7
    Conserved Domains (1) summary
    pfam05700
    Location:1 → 149
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

  3. NM_026602.4 → NP_080878.2  pre-mRNA-splicing factor SPF27 isoform 1

    See identical proteins and their annotated locations for NP_080878.2

    Status: VALIDATED

    Source sequence(s)
    AC150894
    Consensus CDS
    CCDS17691.1
    UniProtKB/Swiss-Prot
    Q3TKJ5, Q91YX8, Q9D287, Q9D2U4, Q9DAI0
    UniProtKB/TrEMBL
    Q3U5M2
    Related
    ENSMUSP00000005830.9, ENSMUST00000005830.15
    Conserved Domains (1) summary
    pfam05700
    Location:11 → 214
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    103078971..103086479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D287.1 GenPept UniProtKB/Swiss-Prot:Q9D287

Gene LinkOut

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