U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nt5c3b 5'-nucleotidase, cytosolic IIIB [ Mus musculus (house mouse) ]

Gene ID: 68106, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Nt5c3bprovided by MGI
Official Full Name
5'-nucleotidase, cytosolic IIIBprovided by MGI
Primary source
MGI:MGI:1915356
See related
Ensembl:ENSMUSG00000017176 AllianceGenome:MGI:1915356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nt5c3l; 2610037D24Rik; C330027I04Rik
Summary
Predicted to enable hydrolase activity; magnesium ion binding activity; and nucleotide binding activity. Predicted to act upstream of or within nucleotide metabolic process. Predicted to be active in cytoplasm. Orthologous to human NT5C3B (5'-nucleotidase, cytosolic IIIB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.3), limb E14.5 (RPKM 21.9) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nt5c3b in Genome Data Viewer
Location:
11 D; 11 63.47 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100313143..100332634, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100422317..100441808, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12348 Neighboring gene prolyl 3-hydroxylase family member 4 (non-enzymatic) Neighboring gene FK506 binding protein 10 Neighboring gene kelch-like 10 Neighboring gene kelch-like 11 Neighboring gene STARR-positive B cell enhancer ABC_E3020 Neighboring gene microRNA 7116 Neighboring gene ATP citrate lyase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
7-methylguanosine phosphate-specific 5'-nucleotidase
Names
5'-nucleotidase, cytosolic III-like
7-methylguanosine nucleotidase
N(7)-methylguanylate 5'-phosphatase
cN-III-like protein
cytosolic 5'-nucleotidase 3B
cytosolic 5'-nucleotidase III-like protein
NP_001096120.1
NP_001349895.1
NP_001349896.1
NP_001349897.1
NP_080837.3
XP_006534109.1
XP_017170212.1
XP_017170213.1
XP_017170214.1
XP_017170215.1
XP_017170216.1
XP_017170217.1
XP_030102118.1
XP_030102119.1
XP_030102120.1
XP_030102121.1
XP_036012818.1
XP_036012819.1
XP_036012820.1
XP_036012821.1
XP_036012822.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102650.2 → NP_001096120.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 1

    See identical proteins and their annotated locations for NP_001096120.1

    Status: VALIDATED

    Source sequence(s)
    AK148222, AL590968, BE944684, BY047327
    Consensus CDS
    CCDS48931.1
    UniProtKB/Swiss-Prot
    A2A4I2, A2A4I3, Q3TLP3, Q3UFY7, Q8BHU9, Q91WE8, Q9D9F9
    Related
    ENSMUSP00000090360.6, ENSMUST00000092688.12
    Conserved Domains (1) summary
    cd07504
    Location:17 → 289
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  2. NM_001362966.1 → NP_001349895.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL590968, BE944684
    Consensus CDS
    CCDS88254.1
    Related
    ENSMUSP00000103020.2, ENSMUST00000107397.2
    Conserved Domains (1) summary
    cd07504
    Location:9 → 281
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  3. NM_001362967.1 → NP_001349896.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK011707, AL590968, BE944684
    Consensus CDS
    CCDS88253.1
    UniProtKB/TrEMBL
    A0A0R4J146
    Related
    ENSMUSP00000090361.3, ENSMUST00000092689.9
    Conserved Domains (1) summary
    pfam05822
    Location:1 → 246
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

  4. NM_001362968.1 → NP_001349897.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK166393, AL590968
    Related
    ENSMUST00000130666.2
    Conserved Domains (1) summary
    cl21460
    Location:17 → 76
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  5. NM_026561.5 → NP_080837.3  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 2

    See identical proteins and their annotated locations for NP_080837.3

    Status: VALIDATED

    Source sequence(s)
    AK006972, AL590968
    Consensus CDS
    CCDS48930.1
    UniProtKB/Swiss-Prot
    Q3UFY7
    Related
    ENSMUSP00000103021.2, ENSMUST00000107398.8
    Conserved Domains (1) summary
    pfam05822
    Location:44 → 259
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100313143..100332634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156926.1 → XP_036012819.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X7

    Conserved Domains (1) summary
    cd07504
    Location:4 → 227
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  2. XM_017314725.1 → XP_017170214.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X4

    Conserved Domains (1) summary
    cd07504
    Location:25 → 268
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  3. XM_036156929.1 → XP_036012822.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X9

    Conserved Domains (1) summary
    cl21460
    Location:10 → 192
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  4. XM_030246258.1 → XP_030102118.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    A2A4I2, A2A4I3, Q3TLP3, Q3UFY7, Q8BHU9, Q91WE8, Q9D9F9
    Conserved Domains (1) summary
    cd07504
    Location:17 → 289
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  5. XM_017314727.2 → XP_017170216.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X6

    Conserved Domains (1) summary
    pfam05822
    Location:10 → 222
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

  6. XM_017314728.1 → XP_017170217.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X6

    Conserved Domains (1) summary
    pfam05822
    Location:10 → 222
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

  7. XM_017314726.1 → XP_017170215.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X5

    Conserved Domains (1) summary
    pfam05822
    Location:11 → 256
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

  8. XM_017314723.1 → XP_017170212.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X1

    Conserved Domains (1) summary
    cd07504
    Location:25 → 297
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  9. XM_036156925.1 → XP_036012818.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X6

    Conserved Domains (1) summary
    pfam05822
    Location:10 → 222
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

  10. XM_017314724.3 → XP_017170213.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X3

    Conserved Domains (1) summary
    cd07504
    Location:12 → 264
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  11. XM_036156928.1 → XP_036012821.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

    Conserved Domains (1) summary
    cl21460
    Location:1 → 188
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  12. XM_030246259.1 → XP_030102119.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X6

    Conserved Domains (1) summary
    pfam05822
    Location:10 → 222
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

  13. XM_030246261.2 → XP_030102121.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

    Conserved Domains (1) summary
    cl21460
    Location:1 → 188
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  14. XM_006534046.5 → XP_006534109.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

    See identical proteins and their annotated locations for XP_006534109.1

    Conserved Domains (1) summary
    cl21460
    Location:1 → 188
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  15. XM_030246260.2 → XP_030102120.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

    Conserved Domains (1) summary
    cl21460
    Location:1 → 188
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  16. XM_036156927.1 → XP_036012820.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

    Conserved Domains (1) summary
    cl21460
    Location:1 → 188
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UFY7.3 GenPept UniProtKB/Swiss-Prot:Q3UFY7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous