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Cxxc5 CXXC finger 5 [ Mus musculus (house mouse) ]

Gene ID: 67393, updated on 5-Nov-2024

Summary

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Official Symbol
Cxxc5provided by MGI
Official Full Name
CXXC finger 5provided by MGI
Primary source
MGI:MGI:1914643
See related
Ensembl:ENSMUSG00000046668 AllianceGenome:MGI:1914643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930415K17Rik
Summary
Predicted to enable DNA-binding transcription factor binding activity; methyl-CpG binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and regulation of generation of precursor metabolites and energy. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CXXC5 (CXXC finger protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 24.2), testis adult (RPKM 22.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cxxc5 in Genome Data Viewer
Location:
18 B2; 18 19.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35962432..35994746)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35829379..35861693)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44252 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2D 2A Neighboring gene STARR-seq mESC enhancer starr_44255 Neighboring gene STARR-seq mESC enhancer starr_44256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:35991804-35992030 Neighboring gene predicted gene 29417 Neighboring gene VISTA enhancer mm1664 Neighboring gene STARR-positive B cell enhancer mm9_chr18:36003985-36004286 Neighboring gene VISTA enhancer mm1614 Neighboring gene STARR-positive B cell enhancer ABC_E1206 Neighboring gene predicted gene, 41693 Neighboring gene STARR-seq mESC enhancer starr_44261 Neighboring gene predicted gene, 36315

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis. Ma L, et al. Cell Commun Signal, 2024 Jan 2. PMID 38167023, Free PMC Article
  2. CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation. Kim MY, et al. Glia, 2016 Mar. PMID 26462610
  3. Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment. Seo SH, et al. Exp Mol Med, 2022 Sep. PMID 36114279, Free PMC Article
  4. CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. Kim HY, et al. Cell Death Differ, 2015 Jun. PMID 25633194, Free PMC Article
  5. CXXC5 Attenuates Pulmonary Fibrosis in a Bleomycin-Induced Mouse Model and MLFs by Suppression of the CD40/CD40L Pathway. Cheng W, et al. Biomed Res Int, 2020. PMID 32337277, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis.
    Title: CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis.
  2. Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
    Title: Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
  3. Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/beta-catenin signaling pathway.
    Title: Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/β-catenin signaling pathway.
  4. Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.
    Title: Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.
  5. Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
    Title: Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
  6. CXXC5 orchestrates Stat3/Erk/Akt signaling networks to modulate P. gingivalis-elicited autophagy in cementoblasts.
    Title: CXXC5 orchestrates Stat3/Erk/Akt signaling networks to modulate P. gingivalis-elicited autophagy in cementoblasts.
  7. CXXC5 Attenuates Pulmonary Fibrosis in a Bleomycin-Induced Mouse Model and MLFs by Suppression of the CD40/CD40L Pathway.
    Title: CXXC5 Attenuates Pulmonary Fibrosis in a Bleomycin-Induced Mouse Model and MLFs by Suppression of the CD40/CD40L Pathway.
  8. Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.
    Title: Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.
  9. These results reveal an important role for CXXC5 as a suppressor of longitudinal bone growth involving growth plate activity.
    Title: CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.
  10. Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
    Title: Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC101987

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methyl-CpG binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpG binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of generation of precursor metabolites and energy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CXXC-type zinc finger protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357458.1 → NP_001344387.1  CXXC-type zinc finger protein 5

    Status: VALIDATED

    Source sequence(s)
    AC141471, AI843749
    Consensus CDS
    CCDS29150.1
    UniProtKB/Swiss-Prot
    Q3V0R4, Q8CES6, Q8CF49, Q91WA4
    Conserved Domains (1) summary
    pfam02008
    Location:250 → 291
    zf-CXXC; CXXC zinc finger domain

  2. NM_001357459.1 → NP_001344388.1  CXXC-type zinc finger protein 5

    Status: VALIDATED

    Source sequence(s)
    AC141471, AI843749, AK132950, BC089314
    Consensus CDS
    CCDS29150.1
    UniProtKB/Swiss-Prot
    Q3V0R4, Q8CES6, Q8CF49, Q91WA4
    Conserved Domains (1) summary
    pfam02008
    Location:250 → 291
    zf-CXXC; CXXC zinc finger domain

  3. NM_133687.3 → NP_598448.1  CXXC-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_598448.1

    Status: VALIDATED

    Source sequence(s)
    AI843749, BC089314, BY705532
    Consensus CDS
    CCDS29150.1
    UniProtKB/Swiss-Prot
    Q3V0R4, Q8CES6, Q8CF49, Q91WA4
    Related
    ENSMUSP00000054307.7, ENSMUST00000060722.8
    Conserved Domains (1) summary
    pfam02008
    Location:250 → 291
    zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35962432..35994746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526180.3 → XP_006526243.1  CXXC-type zinc finger protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006526243.1

    UniProtKB/Swiss-Prot
    Q3V0R4, Q8CES6, Q8CF49, Q91WA4
    Conserved Domains (1) summary
    pfam02008
    Location:250 → 291
    zf-CXXC; CXXC zinc finger domain

  2. XM_006526176.5 → XP_006526239.1  CXXC-type zinc finger protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006526239.1

    UniProtKB/Swiss-Prot
    Q3V0R4, Q8CES6, Q8CF49, Q91WA4
    Conserved Domains (1) summary
    pfam02008
    Location:250 → 291
    zf-CXXC; CXXC zinc finger domain

  3. XM_030250576.2 → XP_030106436.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q3V0R4, Q8CES6, Q8CF49, Q91WA4
    Conserved Domains (1) summary
    pfam02008
    Location:250 → 291
    zf-CXXC; CXXC zinc finger domain

  4. XM_036161256.1 → XP_036017149.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q3V0R4, Q8CES6, Q8CF49, Q91WA4
    Conserved Domains (1) summary
    pfam02008
    Location:250 → 291
    zf-CXXC; CXXC zinc finger domain

  5. XM_006526181.5 → XP_006526244.1  CXXC-type zinc finger protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006526244.1

    UniProtKB/Swiss-Prot
    Q3V0R4, Q8CES6, Q8CF49, Q91WA4
    Conserved Domains (1) summary
    pfam02008
    Location:250 → 291
    zf-CXXC; CXXC zinc finger domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WA4.1 GenPept UniProtKB/Swiss-Prot:Q91WA4

Gene LinkOut

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