3AV4,4NW3,5W9Q,4D4W


Conserved Protein Domain Family
zf-CXXC
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pfam02008: zf-CXXC 
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CXXC zinc finger domain
This domain contains eight conserved cysteine residues that bind to two zinc ions. The CXXC domain is found in a variety of chromatin-associated proteins. This domain binds to nonmethyl-CpG dinucleotides. The domain is characterized by two repeats, and shows a peculiar internal duplication in which the second unit is inserted into the first one. Each of these units is characterized by four conserved cysteines, displaying a CXXCXXCX(n)C motif that chelate a Zn+2 ion. The DNA binding interface has been identified by NMR. In eukaryotes, the CXXC domain is found in stramenopiles, plants and metazoans. Plants possess a mono-CXXC domain that is present in distinct chromatin proteins. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases.
Links
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Statistics
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PSSM-Id: 366873
Aligned: 35 rows
Threshold Bit Score: 41.5712
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3AV4_A        358 ENAMKRRRCGVCEVCQQPE-CGKCKACKDMVKFGGTGRSKQ-ACLKRRC 404 
XP_018883582  257 K--KKRKRCGMCAPCRRRInCEQCSSCRNRKT------GHQ-ICKFRKC 296 
Q91WA4        250 SGKKKRKRCGMCAPCRRRInCEQCSSCRNRKT------GHQ-ICKFRKC 291  house mouse
Q29IC4        136 KEPKAGKRCGTCEGCRRPN-CNQCNACRIRVG------HKP-RCIYRTC 176  Drosophila pseudoobscura
Q7ZYD4        210 RVLHKSDECGVCQGCCREDdCEGCSVCLDKMHKPGMDIKEK--CLQRRC 256  African clawed frog
Q28EE6        211 RNLRKGDDCGMCQGCQRDDdCEGCSVCLDKMHKPDADIKER--CLLRRC 257  tropical clawed frog
Q28EE6        163 QKLHKNTGCGTCEACKVTEnCGHCTVCLLR-SHNPEFSSSW-KCVRRRC 209  tropical clawed frog
Q2KIY8        168 QRMFKRVGCGECTACQVKEdCGACSTCLLQLPHDVASGLFC-KCERRRC 215  cattle
Q9Z2E2        235 RIMEKSRGCGVCRGCQTQEdCGHCCICLRSPR---PGLKRQwRCLQRRC 280  house mouse
4D4W_A          7 QRMFKRVGCGECAACQVTEdCGACSTCLLQLPHDVASGLFC-KCERRRC 54
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