Slc13a2 solute carrier family 13 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc13a2provided by RGD
Official Full Name: solute carrier family 13 member 2provided by RGD
Primary source: RGD:61920
See related: EnsemblRapid:ENSRNOG00000010337 AllianceGenome:RGD:61920
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nadc1; mucin
Summary: Enables dicarboxylic acid transmembrane transporter activity. Involved in cellular response to lithium ion and dicarboxylic acid transport. Located in apical plasma membrane. Orthologous to human SLC13A2 (solute carrier family 13 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 191.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63789874..63817441, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63291813..63319127, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65664665..65692046, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ITF can improve cytomorphosis ability for promoting cell migration with limited effect on cell proliferation, which can be enhanced with addition of mucin. The main mechanism of ITF in maintaining intestinal mucosal barrier may be attributed to acceleration of cell migration.
Title: Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury.
The renal expression of NaDC1 was decreased in the mouse model of obstructive nephropathy. The urinary excretion of NaDC1 increased after short times of ureteral obstruction.
Title: Renal expression and urinary excretion of Na(+)/dicarboxylate cotransporter 1 (NaDC1) in obstructive nephropathy: a candidate biomarker for this pathology.
Cholestasis induced by common bile duct ligation in the rat induces upregulation of NaDC1 in kidneys.
Title: Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction.
These findings may explain the fructo-oligosaccharides-induced early elevation of IgA and mucin
Title: A short-term ingestion of fructo-oligosaccharides increases immunoglobulin A and mucin concentrations in the rat cecum, but the effects are attenuated with the prolonged ingestion.
NaDC1 was predominantly located in discrete apical membrane or subapical areas in proximal kidney tubules.
Title: Localization of the calcium-regulated citrate transport process in proximal tubule cells.
This is the first study on Oat5 and NaDC1 detection in urine.
Title: Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury.

Submit: New GeneRIF Correction

General gene information

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Markers

AI145271 (e-PCR)
- UniSTS:245410

D11Seg22 (e-PCR), detects polymorphism
- UniSTS:141796

AU049977 (e-PCR)
- UniSTS:146419

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-ketoglutarate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fumarate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fumarate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables fumarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:dicarboxylate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:dicarboxylate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:dicarboxylate symporter activity	ISO Inferred from Sequence Orthology more info
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in alpha-ketoglutarate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in alpha-ketoglutarate transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lithium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lithium ion	ISO Inferred from Sequence Orthology more info
involved_in fumarate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fumarate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in fumarate transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in succinate transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 13 member 2

Names: Na(+)/dicarboxylate cotransporter 1; intestinal sodium/dicarboxylate cotransporter; naDC-1; sodium-dependent dicarboxylate transporter; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031746.1 → NP_113934.1 solute carrier family 13 member 2

See identical proteins and their annotated locations for NP_113934.1

Status: PROVISIONAL

Source sequence(s)

AF058714

UniProtKB/Swiss-Prot

O35055, P70545

Related

ENSRNOP00000038185.3, ENSRNOT00000038690.6

Conserved Domains (2) summary

COG0471
Location:42 → 558

CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]

cl21473
Location:7 → 560

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...