|
Name |
Accession |
Description |
Interval |
E-value |
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
7-560 |
2.15e-109 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 335.88 E-value: 2.15e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 7 ALWAYRFYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIVLFPLMGIMDA----SEVCIEY 82
Cdd:pfam00939 2 TLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLakalSWALSGF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 83 FKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVRPalLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGS 162
Cdd:pfam00939 82 SSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 163 kkdveggnNNPTFELQEEcpqkevtkldngqpvsapseprtqktqehHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQ 242
Cdd:pfam00939 160 --------FGSDPEKGSE-----------------------------RRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 243 GQVNSlfpQNGNVVNFASWFGFAFPTMIILLLLAWLWLQVLFLGVNFRKNfgfgegeeerkqAAFQVIKTQYRLLGPMSF 322
Cdd:pfam00939 203 GLMNS---ILGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTF 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 323 AEKTVTVLFVLLVVLWFTRE-PGFfpgwgdtvfanekgqsmaSDGTVAIFISLVMFIIPskipglmqdpkkpgklkappa 401
Cdd:pfam00939 268 REKALLGLFVLLLLLWIFGGsLNI------------------DATTVAIIGLALMLLLR--------------------- 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 402 ILTWK-TVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQ--HIPPSATAVILCLLIAIFTECTSNVATTTLF 478
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLsgFSPAMAFIIILSLFYLSHYLFASATAHTAAM 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 479 LPILASMAQAICLHP-LYVMLPCTLAASLA-FMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSWSIP 556
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468
|
....
gi 13929048 557 IFKL 560
Cdd:pfam00939 469 LGSL 472
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
42-553 |
6.90e-90 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 282.55 E-value: 6.90e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 42 IILMALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVRP 121
Cdd:cd01115 4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 122 ALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGSKkdveggnnnptfelqeecpqkevtkldngqpvsapsep 201
Cdd:cd01115 84 RRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISP-------------------------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 202 rtqktqehhrfsQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSLFPQNGNvvnFASWFGFAFPTMIILlllawlwlq 281
Cdd:cd01115 126 ------------SRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLIIG--------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 282 VLFLgvnfrknfgfgegeeerkqaafqviktqyrllgpmsfaektvtvlfvllvvLWFTREPGFFPGWGDTVFANE-KGQ 360
Cdd:cd01115 182 LLYL---------------------------------------------------WFIFRLAVLIITIVLLAALAAiTGL 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 361 SMASDGTVAIFISLVMFiipskipglmqdpkkpgklkappAILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLG 440
Cdd:cd01115 211 LPVSVAIAIGAIVLVFG-----------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIA 267
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 441 DKLTP-LQHIPPSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAI 519
Cdd:cd01115 268 EALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAI 347
|
490 500 510
....*....|....*....|....*....|....
gi 13929048 520 VFSFGGLKVSDMARAGFLLNIIGVLAITLSINSW 553
Cdd:cd01115 348 VLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLI 381
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
91-553 |
1.24e-82 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 263.17 E-value: 1.24e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 91 VGGLMVAIAVEHWNLHKRIALQVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGSKKdveggn 170
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKR------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 171 nnptfelqeecpqkevtkldngqpvsapseprtqktqehHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSLFP 250
Cdd:COG0471 75 ---------------------------------------SKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATG 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 251 QNgnvVNFASWFGFAFPTMIILLLLawlwlqVLFLGVNFRKNfgfgegEEERKQAAFQVIKTQYRLLGPMSFAEKTVTVL 330
Cdd:COG0471 116 IP---ISFFEWMLVGLPVALVGLLL------LWLVLYRLLPP------EIKEVPGSKEVIREELAELGPLSRREKIALAI 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 331 FVLLVVLWFTREPGFFPgwgdtvfanekgqsmasDGTVAIFISLVMFIipskipglmqdpkkpgklkapPAILTWKTVND 410
Cdd:COG0471 181 FALTVLLWITGSLHGIP-----------------IAVVALLGAVLLLL---------------------TGVLTWKDAYK 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 411 KMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTP-LQHIPPSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAI 489
Cdd:COG0471 223 SIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13929048 490 CLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSW 553
Cdd:COG0471 303 GVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
43-553 |
6.89e-53 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 186.78 E-value: 6.89e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 43 ILMALLWCTEALPLAVTALFPI-VLFPLMGIMDASEV--CIEYFKDTNI-LFVGGLMVAIAVEHWNLHKRIALQVLLIIG 118
Cdd:TIGR00785 18 VAAIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFknALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 119 VRPALL-LLGFMLVTAFLSMWISNTA-TTAMMVPIGHAVLEQLqGSKKDveggnnnptfelqeecpqkevtkldngqpvs 196
Cdd:TIGR00785 98 GTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL-GSKPE------------------------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 197 apseprtqktQEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQvnsLFPQNGNVVNFASWFGFAFPTMIILLLLA 276
Cdd:TIGR00785 146 ----------KSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGI---LSKILGIQISWGDWFLAGLPLGIILLLLV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 277 WLWLQVLFlgvnfrknfgfgEGEEERKQAAFQVIKTQYRLLGPMSFAEKTVTVLFVLLVVLWftrepgffpgwgdtVFAN 356
Cdd:TIGR00785 213 PLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLW--------------IFGG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 357 EKGQSmasDGTVAIFISLVMFIIpskipglmqdpkkpgklkappAILTWKTVN-DKMPWNIVILLGGGFALAKGSEQSGL 435
Cdd:TIGR00785 267 SLGIN---ASVVALLAVVLMLFL---------------------GIVTWKDIQkNKVAWNTLILFGGLIGLAGGLKKSGF 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 436 SEWLGDKLTPLQHIPPSATAV--ILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLA-FMLPV 512
Cdd:TIGR00785 323 IKWFSEKLVGILDGLSPTIAVlvLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPY 402
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 13929048 513 ATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSW 553
Cdd:TIGR00785 403 ATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
7-560 |
2.15e-109 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 335.88 E-value: 2.15e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 7 ALWAYRFYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIVLFPLMGIMDA----SEVCIEY 82
Cdd:pfam00939 2 TLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLakalSWALSGF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 83 FKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVRPalLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGS 162
Cdd:pfam00939 82 SSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 163 kkdveggnNNPTFELQEEcpqkevtkldngqpvsapseprtqktqehHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQ 242
Cdd:pfam00939 160 --------FGSDPEKGSE-----------------------------RRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 243 GQVNSlfpQNGNVVNFASWFGFAFPTMIILLLLAWLWLQVLFLGVNFRKNfgfgegeeerkqAAFQVIKTQYRLLGPMSF 322
Cdd:pfam00939 203 GLMNS---ILGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTF 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 323 AEKTVTVLFVLLVVLWFTRE-PGFfpgwgdtvfanekgqsmaSDGTVAIFISLVMFIIPskipglmqdpkkpgklkappa 401
Cdd:pfam00939 268 REKALLGLFVLLLLLWIFGGsLNI------------------DATTVAIIGLALMLLLR--------------------- 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 402 ILTWK-TVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQ--HIPPSATAVILCLLIAIFTECTSNVATTTLF 478
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLsgFSPAMAFIIILSLFYLSHYLFASATAHTAAM 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 479 LPILASMAQAICLHP-LYVMLPCTLAASLA-FMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSWSIP 556
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468
|
....
gi 13929048 557 IFKL 560
Cdd:pfam00939 469 LGSL 472
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
42-553 |
6.90e-90 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 282.55 E-value: 6.90e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 42 IILMALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVRP 121
Cdd:cd01115 4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 122 ALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGSKkdveggnnnptfelqeecpqkevtkldngqpvsapsep 201
Cdd:cd01115 84 RRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISP-------------------------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 202 rtqktqehhrfsQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSLFPQNGNvvnFASWFGFAFPTMIILlllawlwlq 281
Cdd:cd01115 126 ------------SRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLIIG--------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 282 VLFLgvnfrknfgfgegeeerkqaafqviktqyrllgpmsfaektvtvlfvllvvLWFTREPGFFPGWGDTVFANE-KGQ 360
Cdd:cd01115 182 LLYL---------------------------------------------------WFIFRLAVLIITIVLLAALAAiTGL 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 361 SMASDGTVAIFISLVMFiipskipglmqdpkkpgklkappAILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLG 440
Cdd:cd01115 211 LPVSVAIAIGAIVLVFG-----------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIA 267
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 441 DKLTP-LQHIPPSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAI 519
Cdd:cd01115 268 EALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAI 347
|
490 500 510
....*....|....*....|....*....|....
gi 13929048 520 VFSFGGLKVSDMARAGFLLNIIGVLAITLSINSW 553
Cdd:cd01115 348 VLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLI 381
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
91-553 |
1.24e-82 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 263.17 E-value: 1.24e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 91 VGGLMVAIAVEHWNLHKRIALQVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGSKKdveggn 170
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKR------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 171 nnptfelqeecpqkevtkldngqpvsapseprtqktqehHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSLFP 250
Cdd:COG0471 75 ---------------------------------------SKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATG 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 251 QNgnvVNFASWFGFAFPTMIILLLLawlwlqVLFLGVNFRKNfgfgegEEERKQAAFQVIKTQYRLLGPMSFAEKTVTVL 330
Cdd:COG0471 116 IP---ISFFEWMLVGLPVALVGLLL------LWLVLYRLLPP------EIKEVPGSKEVIREELAELGPLSRREKIALAI 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 331 FVLLVVLWFTREPGFFPgwgdtvfanekgqsmasDGTVAIFISLVMFIipskipglmqdpkkpgklkapPAILTWKTVND 410
Cdd:COG0471 181 FALTVLLWITGSLHGIP-----------------IAVVALLGAVLLLL---------------------TGVLTWKDAYK 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 411 KMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTP-LQHIPPSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAI 489
Cdd:COG0471 223 SIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13929048 490 CLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSW 553
Cdd:COG0471 303 GVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
43-553 |
6.89e-53 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 186.78 E-value: 6.89e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 43 ILMALLWCTEALPLAVTALFPI-VLFPLMGIMDASEV--CIEYFKDTNI-LFVGGLMVAIAVEHWNLHKRIALQVLLIIG 118
Cdd:TIGR00785 18 VAAIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFknALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 119 VRPALL-LLGFMLVTAFLSMWISNTA-TTAMMVPIGHAVLEQLqGSKKDveggnnnptfelqeecpqkevtkldngqpvs 196
Cdd:TIGR00785 98 GTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL-GSKPE------------------------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 197 apseprtqktQEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQvnsLFPQNGNVVNFASWFGFAFPTMIILLLLA 276
Cdd:TIGR00785 146 ----------KSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGI---LSKILGIQISWGDWFLAGLPLGIILLLLV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 277 WLWLQVLFlgvnfrknfgfgEGEEERKQAAFQVIKTQYRLLGPMSFAEKTVTVLFVLLVVLWftrepgffpgwgdtVFAN 356
Cdd:TIGR00785 213 PLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLW--------------IFGG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 357 EKGQSmasDGTVAIFISLVMFIIpskipglmqdpkkpgklkappAILTWKTVN-DKMPWNIVILLGGGFALAKGSEQSGL 435
Cdd:TIGR00785 267 SLGIN---ASVVALLAVVLMLFL---------------------GIVTWKDIQkNKVAWNTLILFGGLIGLAGGLKKSGF 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 436 SEWLGDKLTPLQHIPPSATAV--ILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLA-FMLPV 512
Cdd:TIGR00785 323 IKWFSEKLVGILDGLSPTIAVlvLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPY 402
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 13929048 513 ATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSW 553
Cdd:TIGR00785 403 ATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
46-550 |
1.59e-45 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 165.50 E-value: 1.59e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 46 ALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIiGVRPALLL 125
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 126 LGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGSKkdveggnnnptfelqeecpqkevtkldngqpvsapseprtqk 205
Cdd:cd00625 80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSP------------------------------------------ 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 206 tqehhrfSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNslfpqngnvVNFASWFGFAFPTMIILLLLAWLWLQVLFL 285
Cdd:cd00625 118 -------PVPLLLALAFAANIGGAATPIGNPPNLIIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFR 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 286 GVNFRKNFGFGEGEEERKQAAFQVIKTQYRLLGpmsfaektvtvlfvllVVLWFTREPGFFPGWGdtvfanekgqSMASD 365
Cdd:cd00625 182 KKLLLPDEDKLTVLAEPLPARPLLKKFLLLALL----------------LLLLFVLLFFFLIPLG----------LIALL 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 366 GTVAIFISLVMFiipskipglmqdpkkpgklkappaiLTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTP 445
Cdd:cd00625 236 GALLLLLLLVRG-------------------------LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVA 290
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 446 LQHIPPSATAVILCLLIAIFTECTSNVATTTLFLPILASM-----AQAICLHPLYVMLPCTLAASLAFMLPVATPPNAIV 520
Cdd:cd00625 291 LVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLappepAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGV 370
|
490 500 510
....*....|....*....|....*....|
gi 13929048 521 fsfgGLKVSDMARAGFLLNIIGVLAITLSI 550
Cdd:cd00625 371 ----GISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
46-498 |
2.42e-29 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 118.95 E-value: 2.42e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 46 ALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVRPALLL 125
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 126 LGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLqgskkdveggNNNPTFelqeecpqkevtkldngqpvsapseprtqk 205
Cdd:pfam03600 81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRL----------GLPPSP------------------------------ 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 206 tqehhrfsqgLSLCICYSASIGGIATLTGTTPNLVLQGQVNSLFPQNGnvvnFASWFGFAFPTMIILlllawlwlqVLFL 285
Cdd:pfam03600 121 ----------LLIALAFAANIGGTATPIGDPPNIIIASALGLSFGDFG----FFMFPPVGVALLLVG---------LLPL 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 286 GVNFRKNFGFGEGEEERKQAAFQVIKTQYRLLGpmsfaektvtvlfvllvvlwftrepgffpgwgdtvfanekgqsmASD 365
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLA--------------------------------------------ISA 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 366 GTVAIFISLVMFIIPSKIPGLMQDPKKPgklkappaILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTP 445
Cdd:pfam03600 214 LVLALVILGFLLLSVLALAGALLLLLTG--------VLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGG 285
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 13929048 446 LQhiPPSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLYVML 498
Cdd:pfam03600 286 LS--GLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
399-548 |
8.13e-13 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 70.03 E-value: 8.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 399 PPAILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQHIPPSATAVILCLLIAIFTECTSNVATTTLF 478
Cdd:pfam03600 24 LLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIM 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13929048 479 LPILASMAQAICLHPLYVMLPCTLAASLAFML-PVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITL 548
Cdd:pfam03600 104 IPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGL 174
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
42-159 |
6.82e-12 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 67.10 E-value: 6.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 42 IILMALLWCTEA---LPLAVTALFPIVLFPLMGIMDASEVcieyFKDTN----ILFVGGLMVAIAVEHWNLHKRIALQVL 114
Cdd:COG0471 181 FALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDA----YKSIPwgvlLLFGGGLALGAALEKTGLAAWLADALL 256
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 13929048 115 -LIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQL 159
Cdd:COG0471 257 pLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
6-161 |
7.04e-09 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 57.71 E-value: 7.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 6 PALWAYRFYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFKD 85
Cdd:pfam03600 176 PLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWS 255
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13929048 86 TNILFVGGLMVAIAVEHWNLHKRIAlqVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQG 161
Cdd:pfam03600 256 TLLFFAGLFILVGALEKTGLADALA--DALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGL 329
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
402-548 |
1.01e-08 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 57.45 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 402 ILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQHIPPSATAVILCLLIAIFTECTSNVATTTLFLPI 481
Cdd:COG1055 41 VVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPV 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13929048 482 LASMAQAICLHPLYVMLPCTLAASLA-FMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITL 548
Cdd:COG1055 121 VLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLL 188
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
42-154 |
1.69e-06 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 50.71 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 42 IILMALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFK-DTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVR 120
Cdd:cd00625 216 LLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDwGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLP 295
|
90 100 110
....*....|....*....|....*....|....
gi 13929048 121 PALLLLGFMLVTAFLSMWISNTATTAMMVPIGHA 154
Cdd:cd00625 296 PLAALLLIGLLSALLSNFISNVPTVALLLPIAAS 329
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
54-550 |
1.89e-05 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 47.43 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 54 LPLAVTALFPIVLFPLMGIMDASEVcIEYFkDTN-ILFVGGLMVAIAV-EHWNLHKRIALQVLLIIGVRPALLLLGFMLV 131
Cdd:COG1055 23 LNRAVAALLGAALLLLLGVVSLEDA-LEAI-DWNtILFLLGMMIIVAIlDESGFFEWLAIKLARRAKGSPRRLLWLLGLL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 132 TAFLSMWISNTATTAMMVPIGHAVLEQLQGSkkdveggnnnptfelqeecpqkevtkldngqPVSapseprtqktqehhr 211
Cdd:COG1055 101 TALLSAFLDNDTTALLLTPVVLAIARRLGLN-------------------------------PVP--------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 212 fsqgLSLCICYSASIGGIATLTGTTPNLVLQGQVNslfpqngnvVNFASWFGFAFPTMIILLLLAwlwlqVLFLGVNFRK 291
Cdd:COG1055 135 ----FLIAIVFAANIGGAATPIGNPTNIMIASAGG---------LSFLDFLANLFPPSLVSLLVT-----LLVLYLLFRK 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 292 NFGFGEGEEERKQAAFQviktqYRLLGPMSFAektvtvlfvllvvlwftrepgffpgwgdtVFAnekgqsmasdGTVAIF 371
Cdd:COG1055 197 ELPAAPDLEDDPKEAIK-----DRRLLRISLL-----------------------------VLA----------LLLVGF 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 372 ISLVMFIIPSKIPGLMqdpkkpgkLKAPPAILTWKTVND---KMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQH 448
Cdd:COG1055 233 VLHSFLGLPPALIALL--------GAAVLLLLARVDVREvlkKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTG 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 449 IPPSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLY--VMLPCTLAASLafmLPVATPPNAIVFSF--- 523
Cdd:COG1055 305 GNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPLWlaLALGATLGGNL---TPIGSAANVIVLGIaek 381
|
490 500
....*....|....*....|....*....
gi 13929048 524 GGLKVS--DMARAGFLLNIIGVLAITLSI 550
Cdd:COG1055 382 KGIKISfgEFLKVGLPLTLLTLLIALLYL 410
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
400-531 |
8.54e-03 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 38.77 E-value: 8.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13929048 400 PAILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQHIPPSATAVILCLLIAIFTECTSNVATTTLFL 479
Cdd:cd01116 33 TLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMV 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 13929048 480 PILASMAQAICLHPLYVMLPCTLAASLAFML-PVATPPNAIVFSFGGLKVSDM 531
Cdd:cd01116 113 PVTIRLCEVLGLNPVPVLISEVIAANIGGAAtLIGDPPNIMIGSAAGLTFNDF 165
|
|
| |
