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FAM110C family with sequence similarity 110 member C [ Homo sapiens (human) ]

Gene ID: 642273, updated on 3-Apr-2024

Summary

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Official Symbol
FAM110Cprovided by HGNC
Official Full Name
family with sequence similarity 110 member Cprovided by HGNC
Primary source
HGNC:HGNC:33340
See related
Ensembl:ENSG00000184731 MIM:611395; AllianceGenome:HGNC:33340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables alpha-tubulin binding activity. Involved in positive regulation of cell migration; positive regulation of protein kinase B signaling; and regulation of cell projection assembly. Located in cell cortex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in esophagus (RPKM 9.1), colon (RPKM 5.4) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
2p25.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (38814..46505, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (32180..40449, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38814..46505, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:67739-68240 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:150593-151572 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:151573-152550 Neighboring gene uncharacterized LOC105373324 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:162049-163248 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:197602-198801 Neighboring gene SH3 and SYLF domain containing 1 Neighboring gene MPRA-validated peak3578 silencer Neighboring gene MPRA-validated peak3579 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11099

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of the FAM110 gene family. Hauge H, et al. Genomics, 2007 Jul. PMID 17499476
  2. Evidence for the involvement of FAM110C protein in cell spreading and migration. Hauge H, et al. Cell Signal, 2009 Dec. PMID 19698782
  3. Whole genome association scan for genetic polymorphisms influencing information processing speed. Luciano M, et al. Biol Psychol, 2011 Mar. PMID 21130836, Free PMC Article
  4. Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors. Feng X, et al. Sci Adv, 2022 May 13. PMID 35559673, Free PMC Article
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Varjosalo M, et al. Nat Methods, 2013 Apr. PMID 23455922

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Whole genome association scan for genetic polymorphisms influencing information processing speed.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell projection assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein FAM110C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077710.3 → NP_001071178.2  protein FAM110C

    See identical proteins and their annotated locations for NP_001071178.2

    Status: VALIDATED

    Source sequence(s)
    AC097643
    Consensus CDS
    CCDS42645.1
    UniProtKB/Swiss-Prot
    Q1W6H9
    UniProtKB/TrEMBL
    B4DYQ4
    Related
    ENSP00000328347.4, ENST00000327669.5
    Conserved Domains (2) summary
    pfam14160
    Location:194 → 303
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:14 → 49
    FAM110_N; Centrosome-associated N terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    38814..46505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510372.3 → XP_011508674.1  protein FAM110C isoform X3

    See identical proteins and their annotated locations for XP_011508674.1

    UniProtKB/TrEMBL
    B4DYQ4
    Conserved Domains (2) summary
    pfam14160
    Location:194 → 303
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:14 → 49
    FAM110_N; Centrosome-associated N terminus

  2. XM_017004690.2 → XP_016860179.1  protein FAM110C isoform X1

    UniProtKB/TrEMBL
    B4DYQ4

  3. XM_017004692.2 → XP_016860181.1  protein FAM110C isoform X2

    UniProtKB/TrEMBL
    B4DYQ4

RNA

  1. XR_001738890.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    32180..40449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343348.1 → XP_054199323.1  protein FAM110C isoform X4

  2. XM_054343349.1 → XP_054199324.1  protein FAM110C isoform X4

  3. XM_054343347.1 → XP_054199322.1  protein FAM110C isoform X3

  4. XM_054343344.1 → XP_054199319.1  protein FAM110C isoform X1

  5. XM_054343345.1 → XP_054199320.1  protein FAM110C isoform X1

  6. XM_054343346.1 → XP_054199321.1  protein FAM110C isoform X2

RNA

  1. XR_008486486.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1W6H9.2 GenPept UniProtKB/Swiss-Prot:Q1W6H9

Gene LinkOut

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