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cluha clustered mitochondria (cluA/CLU1) homolog a [ Danio rerio (zebrafish) ]

Gene ID: 562666, updated on 19-Jun-2024

Summary

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Official Symbol
cluhaprovided by ZNC
Official Full Name
clustered mitochondria (cluA/CLU1) homolog aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061103-457
See related
Ensembl:ENSDARG00000030913 AllianceGenome:ZFIN:ZDB-GENE-061103-457
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cluh; cb498; sb:cb498; wu:fb77e08; wu:fd36f07; wu:fe05g06; wu:fi27b10; zgc:152873
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in intracellular distribution of mitochondria. Predicted to be active in cytoplasm. Is expressed in several structures, including adaxial cell; eye; midbrain; musculature system; and pleuroperitoneal region. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See cluha in Genome Data Viewer
Location:
chromosome: 15
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (25321572..25367283, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (25386309..25432022, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene methyltransferase 16, N6-methyladenosine Neighboring gene platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a Neighboring gene coiled-coil domain containing 92Ba Neighboring gene TLC domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary plasticity of segmentation clock networks. Krol AJ, et al. Development, 2011 Jul. PMID 21652651, Free PMC Article
  2. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
  3. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • KIAA0664

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intracellular distribution of mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular distribution of mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within organelle organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
clustered mitochondria protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077560.1 → NP_001071028.1  clustered mitochondria protein homolog

    See identical proteins and their annotated locations for NP_001071028.1

    Status: PROVISIONAL

    Source sequence(s)
    BC125829
    UniProtKB/Swiss-Prot
    A0JMD0, Q5CZT5
    Related
    ENSDARP00000047470.5, ENSDART00000047471.8
    Conserved Domains (6) summary
    sd00006
    Location:1172 → 1200
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:879 → 1058
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:401 → 621
    CLU; Clustered mitochondria
    pfam13374
    Location:1131 → 1170
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:1210 → 1288
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:110 → 183
    CLU_N; Mitochondrial function, CLU-N-term

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    25321572..25367283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157586.4 → XP_005157643.1  clustered mitochondria protein homolog isoform X2

    UniProtKB/TrEMBL
    A0A8M2B4G7
    Conserved Domains (6) summary
    sd00006
    Location:1143 → 1171
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:850 → 1029
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:401 → 621
    CLU; Clustered mitochondria
    pfam13374
    Location:1102 → 1141
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:1181 → 1259
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:110 → 183
    CLU_N; Mitochondrial function, CLU-N-term

  2. XM_005157587.4 → XP_005157644.1  clustered mitochondria protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A8M2B4F2
    Conserved Domains (6) summary
    sd00006
    Location:1122 → 1150
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:829 → 1008
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:351 → 571
    CLU; Clustered mitochondria
    pfam13374
    Location:1081 → 1120
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:1160 → 1238
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:60 → 133
    CLU_N; Mitochondrial function, CLU-N-term

  3. XM_021481439.1 → XP_021337114.1  clustered mitochondria protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A8M9QHB0
    Conserved Domains (5) summary
    sd00006
    Location:1172 → 1200
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:876 → 1058
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:401 → 621
    CLU; Clustered mitochondria
    pfam13424
    Location:1212 → 1288
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:110 → 183
    CLU_N; Mitochondrial function, CLU-N-term
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JMD0.1 GenPept UniProtKB/Swiss-Prot:A0JMD0

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