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Conserved domains on  [gi|117606121|ref|NP_001071028|]
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clustered mitochondria protein homolog [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLU pfam13236
Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found ...
 401-621 3.47e-103

Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.


:

Pssm-ID: 463814  Cd Length: 225  Bit Score: 327.59  E-value: 3.47e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   401 DWNEELQTTRELSRKNLPERLLRERAIFKVHSDFAAAATRGAMAVIDGNVMAINPGEETRMQMFIWNNIFFSLGFDVRDH 480
Cdd:pfam13236    1 DWNEEFQSLRELPRETLQERLLRERLLSKLASDFVEAATKGAKAIIDGNVLPLNPKEPPGGHKYLYNNIFFSFAVDVRGT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   481 YRELGGDSAAHAAPTNDLNGVRAYSAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQ----SVIYGSIDFGKTV 556
Cdd:pfam13236   81 YPSLGGDEAARKAAGKDLKGVKALNRLDIPGLHTLLTAIVDYRGYRLIAQSILPGILSRDEETiekdTIVYGSSDGGKTV 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117606121   557 VSHPKYLELLEKTSRPLKVQRHAVLNEKDSAVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNF 621
Cdd:pfam13236  161 HSDEEFHELLKKIAKALNLKPHKVGDADGKPVELYGSADIKGIKGTDGRYYVLDLARLFPPDVNF 225
eIF3_p135 pfam12807
Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a ...
 876-1058 1.38e-75

Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.


:

Pssm-ID: 463717  Cd Length: 168  Bit Score: 247.87  E-value: 1.38e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   876 SSLPMDGATLTEALHQRGINVRYLGTVLEFMDNMPAKAQLEHIYRIGISELITRCAKHIFKTYLQGVDLSALSAAVSYFL 955
Cdd:pfam12807    1 SSFPMDGQSLTEALHKRGINMRYLGKIAKKLSKSPNKARLEHLKRLCVQEMIARAAKHILRKYLRGVPPPLLSAAVSHFL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   956 NCLLSSFPDAVAHLPADELVSRKKSRKrrnrvpgggdNTAWASLTPSELWKNITSEAHGYYNFSLQCESVDQavekyGLQ 1035
Cdd:pfam12807   81 NCLLGSSLNPKPTAEIDELLKGLYKKK----------NRAWAKLTPESLWEEIEQEVKSRFRYELPEDWVDS-----GLQ 145

                          170       180
                   ....*....|....*....|...
gi 117606121  1036 KITLLREISIKTGIQILIKEYNF 1058
Cdd:pfam12807  146 KISLLREICLKTGIQLLAREYNF 168
CLU_N pfam15044
Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, ...
 110-183 8.24e-15

Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organizms. The function of this domain is not known. It family is found in association with pfam13236.


:

Pssm-ID: 464466  Cd Length: 79  Bit Score: 70.75  E-value: 8.24e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117606121   110 PQEMVQEIHQVLMDREDTCHRTCFSL---QLDGNVLDNFAELKSI--EGLQEGSLLKVVEEPYTVREARIHVRHIRDLL 183
Cdd:pfam15044    1 KSETVQDLRQVLSELPATKYLTNYHLeyqNGNGERLNEFVTLSEIieELDVDELKLQLKEKPYTEREALEHVLRFREFI 79
TPR_12 pfam13424
Tetratricopeptide repeat;
1212-1288 7.58e-11

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 59.32  E-value: 7.58e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117606121  1212 EMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRSLKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKN 1288
Cdd:pfam13424    1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
FxSxx_TPR super family cl48889
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1109-1294 5.69e-10

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


The actual alignment was detected with superfamily member NF040586:

Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 64.17  E-value: 5.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1109 ELINEALNLFNNVYGAMHVEICACLRLLArLNY-IMGDHPEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALYCFANGQ 1187
Cdd:NF040586  499 ELDEETLERHRRVFGEDHPRTLRAANNLA-VSLrLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGR 577

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1188 LSTALKLLYRA-RYLMLVVCGEDHPEMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRS---LKVALSHhlvA 1263
Cdd:NF040586  578 YAEALDLLEEAlERYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHpdtLAAALSL---A 654

                         170       180       190
                  ....*....|....*....|....*....|.
gi 117606121 1264 RVYESKAEFRSALQHEKEGYTIYKNQVGEAH 1294
Cdd:NF040586  655 NDLRALGDADEARELAREVLDRYRRVLGEDH 685
 
Name Accession Description Interval E-value
CLU pfam13236
Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found ...
 401-621 3.47e-103

Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.


Pssm-ID: 463814  Cd Length: 225  Bit Score: 327.59  E-value: 3.47e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   401 DWNEELQTTRELSRKNLPERLLRERAIFKVHSDFAAAATRGAMAVIDGNVMAINPGEETRMQMFIWNNIFFSLGFDVRDH 480
Cdd:pfam13236    1 DWNEEFQSLRELPRETLQERLLRERLLSKLASDFVEAATKGAKAIIDGNVLPLNPKEPPGGHKYLYNNIFFSFAVDVRGT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   481 YRELGGDSAAHAAPTNDLNGVRAYSAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQ----SVIYGSIDFGKTV 556
Cdd:pfam13236   81 YPSLGGDEAARKAAGKDLKGVKALNRLDIPGLHTLLTAIVDYRGYRLIAQSILPGILSRDEETiekdTIVYGSSDGGKTV 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117606121   557 VSHPKYLELLEKTSRPLKVQRHAVLNEKDSAVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNF 621
Cdd:pfam13236  161 HSDEEFHELLKKIAKALNLKPHKVGDADGKPVELYGSADIKGIKGTDGRYYVLDLARLFPPDVNF 225
eIF3_p135 pfam12807
Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a ...
 876-1058 1.38e-75

Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.


Pssm-ID: 463717  Cd Length: 168  Bit Score: 247.87  E-value: 1.38e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   876 SSLPMDGATLTEALHQRGINVRYLGTVLEFMDNMPAKAQLEHIYRIGISELITRCAKHIFKTYLQGVDLSALSAAVSYFL 955
Cdd:pfam12807    1 SSFPMDGQSLTEALHKRGINMRYLGKIAKKLSKSPNKARLEHLKRLCVQEMIARAAKHILRKYLRGVPPPLLSAAVSHFL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   956 NCLLSSFPDAVAHLPADELVSRKKSRKrrnrvpgggdNTAWASLTPSELWKNITSEAHGYYNFSLQCESVDQavekyGLQ 1035
Cdd:pfam12807   81 NCLLGSSLNPKPTAEIDELLKGLYKKK----------NRAWAKLTPESLWEEIEQEVKSRFRYELPEDWVDS-----GLQ 145

                          170       180
                   ....*....|....*....|...
gi 117606121  1036 KITLLREISIKTGIQILIKEYNF 1058
Cdd:pfam12807  146 KISLLREICLKTGIQLLAREYNF 168
CLU-central cd15466
An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the ...
 879-1058 1.46e-59

An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the mitochondrial CLU proteins have been shown to result in clustered mitochondria. CLU proteins include Saccharomyces cerevisiae clustered mitochondria protein (Clu1p, alias translation initiation factor 31/TIF31p), Dictyostelium discoideum clustered mitochondria protein homolog (CluA), Caenorhabditis elegans clustered mitochondria protein homolog (CLUH/ Protein KIAA0664), Drosophila clueless (alias clustered mitochondria protein homolog), Arabidopsis clustered mitochondria protein (CLU, alias friendly mitochondria protein/FMT), and human clustered mitochondria protein homolog (CLUH). Dictyostelium CluA is involved in mitochondrial dynamics and is necessary for both, mitochondrial fission and fusion. Drosophila clueless is essential for cytoplasmic localization and function of cellular mitochondria. The Drosophila clu gene interacts genetically with parkin (park, the Drosophila ortholog of a human gene responsible for many familial cases of Parkinson's disease). Arabidopsis CLU/FMT is required for correct mitochondrial distribution and morphology. The specific role CLU proteins play in mitochondrial processes in not yet known. In an early study, S. cerevisiae Clu1/TIF31p was reported as sometimes being associated with the elF3 translation initiation factor. The authors noted, however, that its tentative assignment as a subunit of elf3 was uncertain, and to date there has been no direct evidence for a role of this protein in translation.


Pssm-ID: 271318  Cd Length: 159  Bit Score: 201.43  E-value: 1.46e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121  879 PMDGATLTEALHQRGINVRYLGTVLEFMDNMPakaQLEHIYRIGISELITRCAKHIFKTYLQGVDLSALSAAVSYFLNCL 958
Cdd:cd15466     1 PIDGASLTELLHRRGINMRYLGKVAELISKLP---KLPHLKRLLLTEMVARAAKHILRAYLRSVPLAELSAAVAHFLNCL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121  959 LSSFPDAVAHLPADELVSRKksrkrrnrvpgggDNTAWASLTPSELWKNITSEAHGYYNFSLQCESVDQavekyGLQKIT 1038
Cdd:cd15466    78 LGSSSNPAPSAEIDEELKPA-------------ADTSWASLTPSFLWKEIKKEVKKRFRYDLPEESLDE-----GLRKLS 139

                         170       180
                  ....*....|....*....|
gi 117606121 1039 LLREISIKTGIQILIKEYNF 1058
Cdd:cd15466   140 LLRELCLKVGIQLLARDYDF 159
CLU_N pfam15044
Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, ...
 110-183 8.24e-15

Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organizms. The function of this domain is not known. It family is found in association with pfam13236.


Pssm-ID: 464466  Cd Length: 79  Bit Score: 70.75  E-value: 8.24e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117606121   110 PQEMVQEIHQVLMDREDTCHRTCFSL---QLDGNVLDNFAELKSI--EGLQEGSLLKVVEEPYTVREARIHVRHIRDLL 183
Cdd:pfam15044    1 KSETVQDLRQVLSELPATKYLTNYHLeyqNGNGERLNEFVTLSEIieELDVDELKLQLKEKPYTEREALEHVLRFREFI 79
TPR_12 pfam13424
Tetratricopeptide repeat;
1212-1288 7.58e-11

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 59.32  E-value: 7.58e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117606121  1212 EMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRSLKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKN 1288
Cdd:pfam13424    1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1109-1294 5.69e-10

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 64.17  E-value: 5.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1109 ELINEALNLFNNVYGAMHVEICACLRLLArLNY-IMGDHPEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALYCFANGQ 1187
Cdd:NF040586  499 ELDEETLERHRRVFGEDHPRTLRAANNLA-VSLrLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGR 577

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1188 LSTALKLLYRA-RYLMLVVCGEDHPEMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRS---LKVALSHhlvA 1263
Cdd:NF040586  578 YAEALDLLEEAlERYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHpdtLAAALSL---A 654

                         170       180       190
                  ....*....|....*....|....*....|.
gi 117606121 1264 RVYESKAEFRSALQHEKEGYTIYKNQVGEAH 1294
Cdd:NF040586  655 NDLRALGDADEARELAREVLDRYRRVLGEDH 685
TPR_12 pfam13424
Tetratricopeptide repeat;
1133-1198 6.89e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.85  E-value: 6.89e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117606121  1133 LRLLARLNYIMGDHPEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALYCFANGQLSTALKLLYRA 1198
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1132-1316 1.88e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1132 CLRLLARLNYIMGDHPEALSNQQKAVLMservlgieHPNTIQEYMHLALYCFANGQLSTALKLLYRARYLmlvvcgedHP 1211
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL--------DP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1212 EMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRsLKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKNQvG 1291
Cdd:COG0457    74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL-YNLGLALLELGRYDEAIEAYERALELDPDDADALYNL-G 151

                         170       180
                  ....*....|....*....|....*
gi 117606121 1292 EAHEKTKESSEYLKYLTQQAVALQR 1316
Cdd:COG0457   152 IALEKLGRYEEALELLEKLEAAALA 176
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1102-1242 1.75e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 49.53  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1102 GFLKEGCELINEALNLFNNVY-GAMHVEIcaclrLLARLNYIM-----GDHPEALSNQQKAVLMSERVLGIEHPNTIQEY 1175
Cdd:NF040586  576 GRYAEALDLLEEALERYREVLgGPDHPDT-----LRAAKSLAValrraGRLEEALELAEDTYERYRRRFGPDHPDTLAAA 650

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117606121 1176 MHLALYCFANGQLSTALKLL------YRARYlmlvvcGEDHPEMALLDSNIGLVLHGVMEYDLSLRFLENALA 1242
Cdd:NF040586  651 LSLANDLRALGDADEARELArevldrYRRVL------GEDHPFTLACRNNLAVLLRALGDPEEARELAEAALE 717
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1102-1211 3.75e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 48.38  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1102 GFLKEGCELINEALNLFNNVYGAMHVEICACLRLLARLNYIMGDHPEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALY 1181
Cdd:NF040586  619 GRLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVL 698

                          90       100       110
                  ....*....|....*....|....*....|
gi 117606121 1182 CFANGQLSTALKLLYRARYLMLVVCGEDHP 1211
Cdd:NF040586  699 LRALGDPEEARELAEAALEGLRERLGPDHP 728
 
Name Accession Description Interval E-value
CLU pfam13236
Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found ...
 401-621 3.47e-103

Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.


Pssm-ID: 463814  Cd Length: 225  Bit Score: 327.59  E-value: 3.47e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   401 DWNEELQTTRELSRKNLPERLLRERAIFKVHSDFAAAATRGAMAVIDGNVMAINPGEETRMQMFIWNNIFFSLGFDVRDH 480
Cdd:pfam13236    1 DWNEEFQSLRELPRETLQERLLRERLLSKLASDFVEAATKGAKAIIDGNVLPLNPKEPPGGHKYLYNNIFFSFAVDVRGT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   481 YRELGGDSAAHAAPTNDLNGVRAYSAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQ----SVIYGSIDFGKTV 556
Cdd:pfam13236   81 YPSLGGDEAARKAAGKDLKGVKALNRLDIPGLHTLLTAIVDYRGYRLIAQSILPGILSRDEETiekdTIVYGSSDGGKTV 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117606121   557 VSHPKYLELLEKTSRPLKVQRHAVLNEKDSAVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNF 621
Cdd:pfam13236  161 HSDEEFHELLKKIAKALNLKPHKVGDADGKPVELYGSADIKGIKGTDGRYYVLDLARLFPPDVNF 225
eIF3_p135 pfam12807
Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a ...
 876-1058 1.38e-75

Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.


Pssm-ID: 463717  Cd Length: 168  Bit Score: 247.87  E-value: 1.38e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   876 SSLPMDGATLTEALHQRGINVRYLGTVLEFMDNMPAKAQLEHIYRIGISELITRCAKHIFKTYLQGVDLSALSAAVSYFL 955
Cdd:pfam12807    1 SSFPMDGQSLTEALHKRGINMRYLGKIAKKLSKSPNKARLEHLKRLCVQEMIARAAKHILRKYLRGVPPPLLSAAVSHFL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121   956 NCLLSSFPDAVAHLPADELVSRKKSRKrrnrvpgggdNTAWASLTPSELWKNITSEAHGYYNFSLQCESVDQavekyGLQ 1035
Cdd:pfam12807   81 NCLLGSSLNPKPTAEIDELLKGLYKKK----------NRAWAKLTPESLWEEIEQEVKSRFRYELPEDWVDS-----GLQ 145

                          170       180
                   ....*....|....*....|...
gi 117606121  1036 KITLLREISIKTGIQILIKEYNF 1058
Cdd:pfam12807  146 KISLLREICLKTGIQLLAREYNF 168
CLU-central cd15466
An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the ...
 879-1058 1.46e-59

An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the mitochondrial CLU proteins have been shown to result in clustered mitochondria. CLU proteins include Saccharomyces cerevisiae clustered mitochondria protein (Clu1p, alias translation initiation factor 31/TIF31p), Dictyostelium discoideum clustered mitochondria protein homolog (CluA), Caenorhabditis elegans clustered mitochondria protein homolog (CLUH/ Protein KIAA0664), Drosophila clueless (alias clustered mitochondria protein homolog), Arabidopsis clustered mitochondria protein (CLU, alias friendly mitochondria protein/FMT), and human clustered mitochondria protein homolog (CLUH). Dictyostelium CluA is involved in mitochondrial dynamics and is necessary for both, mitochondrial fission and fusion. Drosophila clueless is essential for cytoplasmic localization and function of cellular mitochondria. The Drosophila clu gene interacts genetically with parkin (park, the Drosophila ortholog of a human gene responsible for many familial cases of Parkinson's disease). Arabidopsis CLU/FMT is required for correct mitochondrial distribution and morphology. The specific role CLU proteins play in mitochondrial processes in not yet known. In an early study, S. cerevisiae Clu1/TIF31p was reported as sometimes being associated with the elF3 translation initiation factor. The authors noted, however, that its tentative assignment as a subunit of elf3 was uncertain, and to date there has been no direct evidence for a role of this protein in translation.


Pssm-ID: 271318  Cd Length: 159  Bit Score: 201.43  E-value: 1.46e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121  879 PMDGATLTEALHQRGINVRYLGTVLEFMDNMPakaQLEHIYRIGISELITRCAKHIFKTYLQGVDLSALSAAVSYFLNCL 958
Cdd:cd15466     1 PIDGASLTELLHRRGINMRYLGKVAELISKLP---KLPHLKRLLLTEMVARAAKHILRAYLRSVPLAELSAAVAHFLNCL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121  959 LSSFPDAVAHLPADELVSRKksrkrrnrvpgggDNTAWASLTPSELWKNITSEAHGYYNFSLQCESVDQavekyGLQKIT 1038
Cdd:cd15466    78 LGSSSNPAPSAEIDEELKPA-------------ADTSWASLTPSFLWKEIKKEVKKRFRYDLPEESLDE-----GLRKLS 139

                         170       180
                  ....*....|....*....|
gi 117606121 1039 LLREISIKTGIQILIKEYNF 1058
Cdd:cd15466   140 LLRELCLKVGIQLLARDYDF 159
CLU_N pfam15044
Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, ...
 110-183 8.24e-15

Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organizms. The function of this domain is not known. It family is found in association with pfam13236.


Pssm-ID: 464466  Cd Length: 79  Bit Score: 70.75  E-value: 8.24e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117606121   110 PQEMVQEIHQVLMDREDTCHRTCFSL---QLDGNVLDNFAELKSI--EGLQEGSLLKVVEEPYTVREARIHVRHIRDLL 183
Cdd:pfam15044    1 KSETVQDLRQVLSELPATKYLTNYHLeyqNGNGERLNEFVTLSEIieELDVDELKLQLKEKPYTEREALEHVLRFREFI 79
TPR_12 pfam13424
Tetratricopeptide repeat;
1212-1288 7.58e-11

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 59.32  E-value: 7.58e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117606121  1212 EMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRSLKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKN 1288
Cdd:pfam13424    1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1109-1294 5.69e-10

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 64.17  E-value: 5.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1109 ELINEALNLFNNVYGAMHVEICACLRLLArLNY-IMGDHPEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALYCFANGQ 1187
Cdd:NF040586  499 ELDEETLERHRRVFGEDHPRTLRAANNLA-VSLrLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGR 577

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1188 LSTALKLLYRA-RYLMLVVCGEDHPEMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRS---LKVALSHhlvA 1263
Cdd:NF040586  578 YAEALDLLEEAlERYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHpdtLAAALSL---A 654

                         170       180       190
                  ....*....|....*....|....*....|.
gi 117606121 1264 RVYESKAEFRSALQHEKEGYTIYKNQVGEAH 1294
Cdd:NF040586  655 NDLRALGDADEARELAREVLDRYRRVLGEDH 685
TPR_12 pfam13424
Tetratricopeptide repeat;
1133-1198 6.89e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.85  E-value: 6.89e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117606121  1133 LRLLARLNYIMGDHPEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALYCFANGQLSTALKLLYRA 1198
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
TPR_12 pfam13424
Tetratricopeptide repeat;
1095-1157 3.71e-07

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 48.92  E-value: 3.71e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117606121  1095 GQAKVQQGFLKEGCELINEALNLFNNVYGAMHVEICACLRLLARLNYIMGDHPEALSNQQKAV 1157
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERAL 72
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1132-1316 1.88e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1132 CLRLLARLNYIMGDHPEALSNQQKAVLMservlgieHPNTIQEYMHLALYCFANGQLSTALKLLYRARYLmlvvcgedHP 1211
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL--------DP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1212 EMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRsLKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKNQvG 1291
Cdd:COG0457    74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL-YNLGLALLELGRYDEAIEAYERALELDPDDADALYNL-G 151

                         170       180
                  ....*....|....*....|....*
gi 117606121 1292 EAHEKTKESSEYLKYLTQQAVALQR 1316
Cdd:COG0457   152 IALEKLGRYEEALELLEKLEAAALA 176
TPR_12 pfam13424
Tetratricopeptide repeat;
1175-1246 9.84e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 45.07  E-value: 9.84e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117606121  1175 YMHLALYCFANGQLSTALKLLYRARYLMLVVCGEDHPEMALLDSNIGLVLHGVMEYDLSLRFLENALAINTK 1246
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1095-1316 1.73e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1095 GQAKVQQGFLKEGCELINEALNLFNNVYGAmhveicacLRLLARLNYIMGDHPEALSNQQKAVLMservlgieHPNTIQE 1174
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALELDPDDAEA--------LYNLGLAYLRLGRYEEALADYEQALEL--------DPDDAEA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1175 YMHLALYCFANGQLSTALKLLYRARYLmlvvcgedHPEMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRSLK 1254
Cdd:COG0457    79 LNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117606121 1255 vALSHHLVARVYESKAEFRSALQHEKEGYTIYKNQVGEAHEKTKESSEYLKYLTQQAVALQR 1316
Cdd:COG0457   151 -GIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKL 211
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1102-1242 1.75e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 49.53  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1102 GFLKEGCELINEALNLFNNVY-GAMHVEIcaclrLLARLNYIM-----GDHPEALSNQQKAVLMSERVLGIEHPNTIQEY 1175
Cdd:NF040586  576 GRYAEALDLLEEALERYREVLgGPDHPDT-----LRAAKSLAValrraGRLEEALELAEDTYERYRRRFGPDHPDTLAAA 650

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117606121 1176 MHLALYCFANGQLSTALKLL------YRARYlmlvvcGEDHPEMALLDSNIGLVLHGVMEYDLSLRFLENALA 1242
Cdd:NF040586  651 LSLANDLRALGDADEARELArevldrYRRVL------GEDHPFTLACRNNLAVLLRALGDPEEARELAEAALE 717
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1083-1279 2.76e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.45  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1083 PKASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAmhveicacLRLLARLNYIMGDHPEALSNQQKAVLMser 1162
Cdd:COG3914    73 ALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEA--------LFNLGNLLLALGRLEEALAALRRALAL--- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1163 vlgieHPNTIQEYMHLALYCFANGQLSTALKLLYRARYLmlvvcgedHPEMALLDSNIGLVLHGVMEYDLSLRFLENALA 1242
Cdd:COG3914   142 -----NPDFAEAYLNLGEALRRLGRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 117606121 1243 INtkyhgPRSLKvALSHHLVARVYESKAEFRSALQHE 1279
Cdd:COG3914   209 LD-----PDNAD-AHSNLLFALRQACDWEVYDRFEEL 239
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1102-1211 3.75e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 48.38  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1102 GFLKEGCELINEALNLFNNVYGAMHVEICACLRLLARLNYIMGDHPEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALY 1181
Cdd:NF040586  619 GRLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVL 698

                          90       100       110
                  ....*....|....*....|....*....|
gi 117606121 1182 CFANGQLSTALKLLYRARYLMLVVCGEDHP 1211
Cdd:NF040586  699 LRALGDPEEARELAEAALEGLRERLGPDHP 728
TPR_10 pfam13374
Tetratricopeptide repeat;
1131-1170 4.83e-05

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 41.72  E-value: 4.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 117606121  1131 ACLRLLARLNYIMGDHPEALSNQQKAVLMSERVLGIEHPN 1170
Cdd:pfam13374    3 SSLNNLANALRAQGRYDEAEELLEEALAIRERVLGPDHPD 42
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1169-1324 5.83e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 5.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1169 PNTIQEYMHLALYCFANGQLSTALKLLYRARylmlvvcgEDHPEMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYh 1248
Cdd:COG0457     5 PDDAEAYNNLGLAYRRLGRYEEAIEDYEKAL--------ELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1249 gprslkvALSHHLVARVY-------ESKAEFRSALQHEKEGYTIYKNqVGEAHEKTKESSEYLKYLtQQAVALQRTMNEI 1321
Cdd:COG0457    76 -------AEALNNLGLALqalgryeEALEDYDKALELDPDDAEALYN-LGLALLELGRYDEAIEAY-ERALELDPDDADA 146


                  ...
gi 117606121 1322 YKN 1324
Cdd:COG0457   147 LYN 149
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1085-1244 3.59e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1085 ASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAmhveicacLRLLARLNYIMGDHPEALSNQQKAVLMservl 1164
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEA--------FALLGEILLQLGDLDEAIVLLHEALEL----- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1165 gieHPNTIQEYMHLALYCFANGQLSTALKLLYRARylmlvvcgEDHPEMALLDSNIGLVLHGVMEYDLSLRFLENALAIN 1244
Cdd:COG4783    68 ---DPDEPEARLNLGLALLKAGDYDEALALLEKAL--------KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1143-1244 2.63e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.94  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606121 1143 MGDHPEALSNQQKAVLMservlgieHPNTIQEYMHLALYCFANGQLSTALKLLYRARylmlvvcgEDHPEMALLDSNIGL 1222
Cdd:COG5010    67 LGDFEESLALLEQALQL--------DPNNPELYYNLALLYSRSGDKDEAKEYYEKAL--------ALSPDNPNAYSNLAA 130

                          90       100
                  ....*....|....*....|..
gi 117606121 1223 VLHGVMEYDLSLRFLENALAIN 1244
Cdd:COG5010   131 LLLSLGQDDEAKAALQRALGTS 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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