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Uchl5 ubiquitin carboxyl-terminal esterase L5 [ Mus musculus (house mouse) ]

Gene ID: 56207, updated on 17-Aug-2024

Summary

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Official Symbol
Uchl5provided by MGI
Official Full Name
ubiquitin carboxyl-terminal esterase L5provided by MGI
Primary source
MGI:MGI:1914848
See related
Ensembl:ENSMUSG00000018189 AllianceGenome:MGI:1914848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Uch37; 5830413B11Rik
Summary
Predicted to enable endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in forebrain morphogenesis; lateral ventricle development; and midbrain development. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of Ino80 complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; nose; and orbito-sphenoid. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 10.8), placenta adult (RPKM 8.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 F; 1 62.54 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143652993..143683204)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143777234..143807466)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46161 Neighboring gene glutaredoxin 2 Neighboring gene STARR-positive B cell enhancer ABC_E1564 Neighboring gene STARR-positive B cell enhancer ABC_E2564 Neighboring gene Ro60, Y RNA binding protein Neighboring gene predicted gene, 25663 Neighboring gene STARR-positive B cell enhancer ABC_E499 Neighboring gene STARR-seq mESC enhancer starr_02532 Neighboring gene STARR-positive B cell enhancer ABC_E5813 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:145766106-145766315 Neighboring gene predicted gene, 41964 Neighboring gene STARR-seq mESC enhancer starr_02533 Neighboring gene STARR-positive B cell enhancer ABC_E628 Neighboring gene regulator of G-protein signaling 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs. Zhao W, et al. Int J Biol Sci, 2023. PMID 36778113, Free PMC Article
  2. Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells. Ko YM, et al. Arch Biochem Biophys, 2013 Jul 15. PMID 23500140
  3. METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome. Yang X, et al. Exp Cell Res, 2023 Jun 15. PMID 37044315
  4. Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency. Ma YS, et al. Signal Transduct Target Ther, 2020 Apr 1. PMID 32296042, Free PMC Article
  5. Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs. Peth A, et al. J Biol Chem, 2013 Mar 15. PMID 23341450, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome.
    Title: METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome.
  2. NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.
    Title: NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.
  3. Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency.
    Title: Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency.
  4. PI3K-dependent UCHL5 is required for high glucose-induced TGF-betaR1 protein expression in mesangial cells. UCHL5 is also required for high glucose-induced TGF-betaR1 protein deubiquitination, p21(WAF1) and fibronectin protein expression and cell hypertrophy.
    Title: Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells.
  5. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction
    Title: Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs.
  6. this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis
    Title: Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2)  1 citation
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in forebrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lateral ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in midbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic proteasome complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L5
Names
UCH-L5
ubiquitin C-terminal hydrolase 37
ubiquitin C-terminal hydrolase UCH37
ubiquitin thioesterase L5
NP_001153338.1
NP_062508.2
XP_006529823.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159866.1 → NP_001153338.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2

    See identical proteins and their annotated locations for NP_001153338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK017925, BY279731
    Consensus CDS
    CCDS78699.1
    UniProtKB/Swiss-Prot
    Q9WUP7
    Related
    ENSMUSP00000018333.8, ENSMUST00000018333.13
    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:263 → 308
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  2. NM_019562.2 → NP_062508.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

    See identical proteins and their annotated locations for NP_062508.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF148447, AL592403, BY279731
    Consensus CDS
    CCDS15346.1
    UniProtKB/Swiss-Prot
    Q9CVJ4, Q9CXZ3, Q9R107, Q9WUP7
    Related
    ENSMUSP00000140106.2, ENSMUST00000189936.7
    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:264 → 309
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    143652993..143683204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529760.5 → XP_006529823.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:264 → 309
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

RNA

  1. XR_387185.5 RNA Sequence

  2. XR_001785184.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUP7.2 GenPept UniProtKB/Swiss-Prot:Q9WUP7

Gene LinkOut

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