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SELENOS selenoprotein S [ Bos taurus (cattle) ]

Gene ID: 512276, updated on 4-Jun-2024

Summary

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Official Symbol
SELENOSprovided by VGNC
Official Full Name
selenoprotein Sprovided by VGNC
Primary source
VGNC:VGNC:57162
See related
Ensembl:ENSBTAG00000000640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
SELS; VIMP
Summary
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]
Orthologs
human mouse all
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Genomic context

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See SELENOS in Genome Data Viewer
Location:
chromosome: 21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (5245019..5254197)

Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene spindle and kinetochore-associated protein 2-like Neighboring gene uncharacterized LOC132343323 Neighboring gene chondroitin sulfate synthase 1 Neighboring gene leucine rich repeat kinase 1 Neighboring gene microRNA mir-2362

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S. Bubenik JL, et al. PLoS One, 2013. PMID 23614019, Free PMC Article
  2. Characterization of mammalian selenoproteomes. Kryukov GV, et al. Science, 2003 May 30. PMID 12775843
  3. Selenoprotein Gene Nomenclature. Gladyshev VN, et al. J Biol Chem, 2016 Nov 11. PMID 27645994, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC137429

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retrograde protein transport, ER to cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of Derlin-1-VIMP complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
selenoprotein S
Names
VCP interacting membrane selenoprotein
VCP-interacting membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046114.3 → NP_001039579.2  selenoprotein S isoform 1

    See identical proteins and their annotated locations for NP_001039579.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC112740, DV822816, EE934364
    UniProtKB/Swiss-Prot
    Q2KI76
    Related
    ENSBTAP00000000842.7, ENSBTAT00000000842.8
    Conserved Domains (1) summary
    pfam06936
    Location:1 → 188
    Selenoprotein_S; Selenoprotein S (SelS)

  2. NM_001348225.1 → NP_001335154.1  selenoprotein S isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 5' end, which results in translation initiation from an in-frame downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    DN534347, EE243695, EV727840
    Conserved Domains (1) summary
    pfam06936
    Location:1 → 100
    Selenoprotein_S; Selenoprotein S (SelS)

  3. NM_001348226.1 → NP_001335155.1  selenoprotein S isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is alternatively spliced at the 5' end, which results in translation initiation from an in-frame downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    BC112740, DT848352, EE934364, NKLS02000021
    UniProtKB/Swiss-Prot
    Q2KI76
    Conserved Domains (1) summary
    pfam06936
    Location:1 → 100
    Selenoprotein_S; Selenoprotein S (SelS)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    5245019..5254197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KI76.2 GenPept UniProtKB/Swiss-Prot:Q2KI76

Gene LinkOut

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Research Materials