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Conserved domains on  [gi|1133595323|ref|NP_001335155|]
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selenoprotein S isoform 2 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Selenoprotein_S super family cl06134
Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) ...
 1-100 1.15e-59

Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. Selenoprotein S (SelS) is an intrinsically disordered protein. It formsa selenosulfide bond between cys 174 and Sec 188, that has a redox potential -234 mV. In vitro, SelS is an efficient reductase that depends on the presence of selenocysteine. Due to the high reactivity, SelS also has peroxidase activity that can catalyze the reduction of hydrogen peroxide. It is also resistant to inactivation by hydrogen peroxide which might provide evolutionary advantage compared to cysteine containing peroxidases.


The actual alignment was detected with superfamily member pfam06936:

Pssm-ID: 462043 [Multi-domain]  Cd Length: 192  Bit Score: 180.80  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133595323   1 MQEELNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGKSYKGNTRKPQEE-DSPGPSTSSVIPKRKSDRKPLRGGGYNPL 79
Cdd:pfam06936  92 MQEELDAQAEKFKEKQKQLEEEKRRQKIEMWESMQEGKSYKGNAKLAQEEtEETGPSASSAIPKPKPDKKPLRGSGYNPL 171

                          90       100
                  ....*....|....*....|.
gi 1133595323  80 SGEGGGTCSWRPGRRGPSSGG 100
Cdd:pfam06936 172 TGDGGGSCSWRPGRRGPSSGG 192
 
Name Accession Description Interval E-value
Selenoprotein_S pfam06936
Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) ...
 1-100 1.15e-59

Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. Selenoprotein S (SelS) is an intrinsically disordered protein. It formsa selenosulfide bond between cys 174 and Sec 188, that has a redox potential -234 mV. In vitro, SelS is an efficient reductase that depends on the presence of selenocysteine. Due to the high reactivity, SelS also has peroxidase activity that can catalyze the reduction of hydrogen peroxide. It is also resistant to inactivation by hydrogen peroxide which might provide evolutionary advantage compared to cysteine containing peroxidases.


Pssm-ID: 462043 [Multi-domain]  Cd Length: 192  Bit Score: 180.80  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133595323   1 MQEELNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGKSYKGNTRKPQEE-DSPGPSTSSVIPKRKSDRKPLRGGGYNPL 79
Cdd:pfam06936  92 MQEELDAQAEKFKEKQKQLEEEKRRQKIEMWESMQEGKSYKGNAKLAQEEtEETGPSASSAIPKPKPDKKPLRGSGYNPL 171

                          90       100
                  ....*....|....*....|.
gi 1133595323  80 SGEGGGTCSWRPGRRGPSSGG 100
Cdd:pfam06936 172 TGDGGGSCSWRPGRRGPSSGG 192
 
Name Accession Description Interval E-value
Selenoprotein_S pfam06936
Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) ...
 1-100 1.15e-59

Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. Selenoprotein S (SelS) is an intrinsically disordered protein. It formsa selenosulfide bond between cys 174 and Sec 188, that has a redox potential -234 mV. In vitro, SelS is an efficient reductase that depends on the presence of selenocysteine. Due to the high reactivity, SelS also has peroxidase activity that can catalyze the reduction of hydrogen peroxide. It is also resistant to inactivation by hydrogen peroxide which might provide evolutionary advantage compared to cysteine containing peroxidases.


Pssm-ID: 462043 [Multi-domain]  Cd Length: 192  Bit Score: 180.80  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133595323   1 MQEELNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGKSYKGNTRKPQEE-DSPGPSTSSVIPKRKSDRKPLRGGGYNPL 79
Cdd:pfam06936  92 MQEELDAQAEKFKEKQKQLEEEKRRQKIEMWESMQEGKSYKGNAKLAQEEtEETGPSASSAIPKPKPDKKPLRGSGYNPL 171

                          90       100
                  ....*....|....*....|.
gi 1133595323  80 SGEGGGTCSWRPGRRGPSSGG 100
Cdd:pfam06936 172 TGDGGGSCSWRPGRRGPSSGG 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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