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woc without children [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47249, updated on 22-Aug-2024

Summary

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Official Symbol
wocprovided by FlyBase
Official Full Name
without childrenprovided by FlyBase
Primary source
FLYBASE:FBgn0010328
Locus tag
Dmel_CG5965
See related
AllianceGenome:FB:FBgn0010328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5965; Dmel\CG5965; Woc; WOC
Summary
Contributes to chromatin binding activity. Involved in ecdysone biosynthetic process and regulation of transcription by RNA polymerase II. Located in chromosome and nucleus. Part of protein-containing complex. Is expressed in several structures, including embryonic/larval central nervous system; embryonic/larval gut; gastrula embryo; germ band; and ring gland. Orthologous to several human genes including ZMYM3 (zinc finger MYM-type containing 3) and ZMYM4 (zinc finger MYM-type containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
97E11-97E11; 3-92 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27256595..27264055, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23082317..23089777, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tubulin tyrosine ligase-like 6B Neighboring gene Transcription factor IIA L Neighboring gene pelle Neighboring gene antisense RNA:CR44049 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lethal (3) malignant brain tumor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 20E-regulated USP expression and phosphorylation in Drosophila melanogaster. Song Q, et al. Insect Biochem Mol Biol, 2003 Dec. PMID 14599493
  2. The mutation without children(rgl) causes ecdysteroid deficiency in third-instar larvae of Drosophila melanogaster. Wismar J, et al. Dev Biol, 2000 Oct 1. PMID 10993670
  3. The zinc-finger proteins WOC and ROW play distinct functions within the HP1c transcription complex. Di Mauro G, et al. Biochim Biophys Acta Gene Regul Mech, 2020 Mar. PMID 32006714
  4. If the cap fits, wear it: an overview of telomeric structures over evolution. Fulcher N, et al. Cell Mol Life Sci, 2014 Mar. PMID 24042202, Free PMC Article
  5. Heterochromatin Protein 1a (HP1a) partner specificity is determined by critical amino acids in the chromo shadow domain and C-terminal extension. Mendez DL, et al. J Biol Chem, 2013 Aug 2. PMID 23793104, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that WOC and ROW play distinct functions within the HP1c complex, supporting a model in which WOC interacts with Dsk2 and recruits it to the complex, while ROW mediates binding of the complex to chromatin.
    Title: The zinc-finger proteins WOC and ROW play distinct functions within the HP1c transcription complex.
  2. Without children is required for Stat-mediated zfh1 transcription and for germline stem cell differentiation.
    Title: Without children is required for Stat-mediated zfh1 transcription and for germline stem cell differentiation.
  3. interaction between HP1c and Woc constitutes a transcriptional feedback loop that operates to balance the concentration of HP1c within the cell
    Title: Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc.
  4. HP1c, WOC, and ROW regulate a common gene expression program that, in part, is executed in the context of the nervous system.
    Title: Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression.
  5. Woc gene mutation causes 20E-dependent alpha-tubulin detyrosination in Drosophila melanogaster.
    Title: Woc gene mutation causes 20E-dependent alpha-tubulin detyrosination in Drosophila melanogaster.
  6. Data show that mutations in the woc gene cause frequent telomeric fusions in Drosophila brain cells.
    Title: The putative Drosophila transcription factor woc is required to prevent telomeric fusions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to chromatin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ecdysone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
part_of euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
without children
Names
CG5965-PA
CG5965-PB
CG5965-PC
CG5965-PD
CG5965-PE
with out children
woc-PA
woc-PB
woc-PC
woc-PD
woc-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27256595..27264055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276081.1 → NP_001263010.1  without children, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263010.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHZ0, Q6AWL3
    Conserved Domains (3) summary
    smart00746
    Location:683 → 720
    TRASH; metallochaperone-like domain
    pfam06467
    Location:723 → 761
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1530 → 1689
    DUF3504; Domain of unknown function (DUF3504)

  2. NM_001104476.2 → NP_001097946.1  without children, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097946.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRE3, Q6AWL3
    Conserved Domains (3) summary
    smart00746
    Location:684 → 721
    TRASH; metallochaperone-like domain
    pfam06467
    Location:724 → 762
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1531 → 1690
    DUF3504; Domain of unknown function (DUF3504)

  3. NM_001276080.1 → NP_001263009.1  without children, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263009.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI43, Q6AWL3
    Conserved Domains (3) summary
    smart00746
    Location:668 → 705
    TRASH; metallochaperone-like domain
    pfam06467
    Location:708 → 746
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1515 → 1674
    DUF3504; Domain of unknown function (DUF3504)

  4. NM_080147.3 → NP_524886.2  without children, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524886.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWL3, Q9VB55
    Related
    FBpp0084548
    Conserved Domains (3) summary
    smart00746
    Location:669 → 706
    TRASH; metallochaperone-like domain
    pfam06467
    Location:709 → 747
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1516 → 1675
    DUF3504; Domain of unknown function (DUF3504)

  5. NM_001260397.1 → NP_001247326.1  without children, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247326.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7W6
    Conserved Domains (1) summary
    pfam12012
    Location:540 → 699
    DUF3504; Domain of unknown function (DUF3504)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7W6 A0A0B4K7W6
A0A0B4KHZ0 A0A0B4KHZ0
A0A0B4KI43 A0A0B4KI43
A8JRE3 A8JRE3
Q6AWL3 Q6AWL3
Q95TK6 Q95TK6
Q9N9Z6 Q9N9Z6
Q9VB55 Q9VB55

Gene LinkOut

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