aldh1l1.L aldehyde dehydrogenase 1 family member L1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: aldh1l1.L
Official Full Name: aldehyde dehydrogenase 1 family member L1 L homeolog
Primary source: Xenbase:XB-GENE-1016244
Locus tag: XELAEV_18023971mg
See related: EnsemblRapid:ENSXLAG00005023579 AllianceGenome:Xenbase:XB-GENE-1016244
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: FDH; aldh1l1
Summary: Predicted to enable formyltetrahydrofolate dehydrogenase activity. Predicted to act upstream of or within 10-formyltetrahydrofolate catabolic process and NADPH regeneration. Predicted to be located in cytosol. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (132962188..132992882)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (127714457..127745334)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables aldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables formyltetrahydrofolate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables formyltetrahydrofolate dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 10-formyltetrahydrofolate catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within 10-formyltetrahydrofolate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within NADPH regeneration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytosolic 10-formyltetrahydrofolate dehydrogenase

Names: 10-FTHFDH; 10-formyltetrahydrofolate dehydrogenase; aldehyde dehydrogenase 1 family, member L1; aldehyde dehydrogenase family 1 member L1

NP_001085894.1

EC 1.5.1.6

XP_018112200.1

EC 1.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092425.2 → NP_001085894.1 cytosolic 10-formyltetrahydrofolate dehydrogenase

See identical proteins and their annotated locations for NP_001085894.1

Status: PROVISIONAL

Source sequence(s)

BC073490

UniProtKB/Swiss-Prot

Q6GNL7

Related

ENSXLAP00005069831.1, ENSXLAT00005071366.1

Conserved Domains (5) summary

cd07140
Location:417 → 902

ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L

cd08647
Location:1 → 203

FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain

cd08703
Location:206 → 306

FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase

COG0223
Location:1 → 305

Fmt; Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]

pfam00550
Location:325 → 391

PP-binding; Phosphopantetheine attachment site