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trim2.S tripartite motif containing 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 443918, updated on 4-Nov-2024

Summary

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Official Symbol
trim2.S
Official Full Name
tripartite motif containing 2 S homeolog
Primary source
Xenbase:XB-GENE-942464
Locus tag
XELAEV_18009220mg
See related
EnsemblRapid:ENSXLAG00005033932 AllianceGenome:Xenbase:XB-GENE-942464
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
trim2
Summary
Predicted to enable translation repressor activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to act upstream of or within negative regulation of translation; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See trim2.S in Genome Data Viewer
Location:
chromosome: 1S
Exon count:
15
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (44194434..44245138, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (43925965..43965249, complement)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene toll like receptor 2 S homeolog Neighboring gene transmembrane 131 like S homeolog Neighboring gene uncharacterized LOC108706053 Neighboring gene FH2 domain containing 1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interplay of TRIM2 E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis. Lokapally A, et al. Cells, 2020 Jul 20. PMID 32698497, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interplay of TRIM2 E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis.
    Title: Interplay of TRIM2 E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC80218

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation repressor activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tripartite motif containing 2 S homeolog
Names
tripartite motif-containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092023.1 → NP_001085492.1  tripartite motif containing 2 S homeolog

    See identical proteins and their annotated locations for NP_001085492.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072842
    UniProtKB/TrEMBL
    A0A974DS04, Q6GQA4
    Related
    ENSXLAP00005101345.1, ENSXLAT00005103322.1
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:2 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    44194434..44245138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041575227.1 → XP_041431161.1  tripartite motif containing 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974DS04, Q6GQA4
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:2 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  2. XM_041575224.1 → XP_041431158.1  tripartite motif containing 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974DS04, Q6GQA4
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:2 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  3. XM_018236810.2 → XP_018092299.1  tripartite motif containing 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974DS04, Q6GQA4
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:2 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  4. XM_018236814.2 → XP_018092303.1  tripartite motif containing 2 S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A1L8HLP6, A0A974DS54

  5. XM_041575231.1 → XP_041431165.1  tripartite motif containing 2 S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1LR11
    Conserved Domains (4) summary
    smart00502
    Location:75 → 201
    BBC; B-Box C-terminal domain
    smart00557
    Location:239 → 335
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:385 → 662
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd19824
    Location:29 → 70
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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