U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fru fruitless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42226, updated on 27-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
fruprovided by FlyBase
Official Full Name
fruitlessprovided by FlyBase
Primary source
FLYBASE:FBgn0004652
Locus tag
Dmel_CG14307
See related
AllianceGenome:FB:FBgn0004652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BTB-VI; BtbVI; CG14307; cg7688; CG7688; cg7689; CG7689; CG7690; CT22773; Dmel\CG14307; Dmfru; Fru; FRU; FRU-PI; fruC; FruM; fry; fty; ms(3)06411; sat
Summary
Predicted to enable DNA-binding transcription factor activity. Involved in several processes, including aggressive behavior; mating behavior; and neuron development. Predicted to be active in nucleus. Is expressed in several structures, including adult; central nervous system; chemosensory system; imaginal disc; and reproductive system. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
91A6-91B3; 3-64 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18414273..18545586, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14239995..14371308, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hemotin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutually exclusive expression of sex-specific and non-sex-specific fruitless gene products in the Drosophila central nervous system. Sato K, et al. Gene Expr Patterns, 2022 Mar. PMID 35124238
  2. Drosophila sechellia: A Genetic Model for Behavioral Evolution and Neuroecology. Auer TO, et al. Annu Rev Genet, 2021 Nov 23. PMID 34530638
  3. Generation and characterization of fruitless P1 promoter mutant in Drosophila melanogaster. Neville MC, et al. J Neurogenet, 2021 Sep. PMID 34338589, Free PMC Article
  4. A non-coding indel polymorphism in the fruitless gene of Drosophila melanogaster exhibits antagonistically pleiotropic fitness effects. Jardine MD, et al. Proc Biol Sci, 2021 May 12. PMID 33975471, Free PMC Article
  5. Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization. Brovkina MV, et al. PLoS Genet, 2021 Feb. PMID 33600447, Free PMC Article

See all (490) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of fruitless in specifying courtship behaviors across divergent Drosophila species.
    Title: The role of fruitless in specifying courtship behaviors across divergent Drosophila species.
  2. Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.
    Title: Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.
  3. From fruitless to sex: On the generation and diversification of an innate behavior.
    Title: From fruitless to sex: On the generation and diversification of an innate behavior.
  4. fruitless tunes functional flexibility of courtship circuitry during development.
    Title: fruitless tunes functional flexibility of courtship circuitry during development.
  5. Generation and characterization of fruitless P1 promoter mutant in Drosophila melanogaster.
    Title: Generation and characterization of fruitless P1 promoter mutant in Drosophila melanogaster.
  6. Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior.
    Title: Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior.
  7. Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization.
    Title: Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization.
  8. Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons.
    Title: Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons.
  9. Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophila.
    Title: Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophila.
  10. Drosulfakinin (DSKM) and fruitless (fruM)-expressing neurons inhibit male courtship.
    Title: Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

mobile_element

  • Loc: c18465625-18465569 mobile_element_type = transposon:Doc3{}5636

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in aggressive behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon midline choice point recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in central nervous system neuron development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in copulation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in copulation TAS
Traceable Author Statement
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in male courtship behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in male courtship behavior, orientation prior to leg tapping and wing vibration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in male courtship behavior, tapping to detect pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior, veined wing extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior, veined wing generated song production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior, veined wing generated song production TAS
Traceable Author Statement
more info
 PubMed 
involved_in male courtship behavior, veined wing vibration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male sex differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating behavior, sex discrimination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mating behavior, sex discrimination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating behavior, sex discrimination TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sex determination TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
fruitless
Names
BTB-protein-VI
CG14307-PA
CG14307-PB
CG14307-PC
CG14307-PD
CG14307-PE
CG14307-PF
CG14307-PG
CG14307-PH
CG14307-PI
CG14307-PJ
CG14307-PK
CG14307-PL
CG14307-PM
CG14307-PN
CG14307-PO
fru-PA
fru-PB
fru-PC
fru-PD
fru-PE
fru-PF
fru-PG
fru-PH
fru-PI
fru-PJ
fru-PK
fru-PL
fru-PM
fru-PN
fru-PO
fru-satori
fruity
satori

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18414273..18545586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079673.3 → NP_524397.2  fruitless, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524397.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Related
    FBpp0083064
    Conserved Domains (5) summary
    smart00225
    Location:31 → 115
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00614
    Location:643 → 680
    ZnF_BED; BED zinc finger
    sd00017
    Location:632 → 649
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20 → 115
    BTB; BTB/POZ domain
    cl19237
    Location:615 → 666
    DUF45; Protein of unknown function DUF45

  2. NM_169816.2 → NP_732344.1  fruitless, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732344.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Related
    FBpp0083061
    Conserved Domains (3) summary
    smart00614
    Location:744 → 781
    ZnF_BED; BED zinc finger
    sd00017
    Location:733 → 750
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:130 → 213
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

  3. NM_169817.2 → NP_732345.1  fruitless, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732345.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Related
    FBpp0083065
    Conserved Domains (2) summary
    sd00019
    Location:638 → 655
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:130 → 213
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

  4. NM_169818.2 → NP_732346.1  fruitless, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Related
    FBpp0083060
    Conserved Domains (3) summary
    smart00225
    Location:31 → 115
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:561 → 577
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20 → 115
    BTB; BTB/POZ domain

  5. NM_001275783.1 → NP_001262712.1  fruitless, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG97
    Conserved Domains (3) summary
    smart00225
    Location:31 → 115
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:537 → 554
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20 → 115
    BTB; BTB/POZ domain

  6. NM_206514.2 → NP_996236.1  fruitless, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996236.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Conserved Domains (3) summary
    smart00225
    Location:41 → 125
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:571 → 587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:30 → 125
    BTB; BTB/POZ domain

  7. NM_169819.2 → NP_732347.1  fruitless, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732347.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V334, O44708, P91618, P91619, Q24004, Q29QE0, Q7KSD2, Q7KSD5, Q7KSD6, Q8IN80, Q8IN81, Q8IN82, Q8IN83, Q8IS35, Q8IS36, Q9GU18, Q9GU19, Q9GU20, Q9GU21, Q9GU22, Q9VE64, Q9VE65, Q9VE66, Q9VE67
    Related
    FBpp0083063
    Conserved Domains (3) summary
    smart00225
    Location:132 → 216
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:896 → 913
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:121 → 216
    BTB; BTB/POZ domain

  8. NM_001170177.2 → NP_001163648.1  fruitless, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIP5
    Conserved Domains (3) summary
    smart00225
    Location:137 → 221
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:901 → 918
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:126 → 221
    BTB; BTB/POZ domain

  9. NM_169820.2 → NP_732348.1  fruitless, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732348.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Related
    FBpp0083062
    Conserved Domains (3) summary
    smart00225
    Location:31 → 115
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:795 → 812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20 → 115
    BTB; BTB/POZ domain

  10. NM_206516.2 → NP_996238.1  fruitless, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996238.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Conserved Domains (3) summary
    smart00225
    Location:47 → 131
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:811 → 828
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:36 → 131
    BTB; BTB/POZ domain

  11. NM_206515.2 → NP_996237.1  fruitless, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Conserved Domains (3) summary
    smart00225
    Location:83 → 167
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:847 → 864
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:72 → 167
    BTB; BTB/POZ domain

  12. NM_206513.2 → NP_996235.1  fruitless, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996235.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Conserved Domains (3) summary
    smart00225
    Location:31 → 115
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:795 → 812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20 → 115
    BTB; BTB/POZ domain

  13. NM_206512.2 → NP_996234.1  fruitless, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996234.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Conserved Domains (3) summary
    smart00225
    Location:31 → 115
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:795 → 812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20 → 115
    BTB; BTB/POZ domain

  14. NM_169821.2 → NP_732349.1  fruitless, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732349.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Related
    FBpp0083066
    Conserved Domains (2) summary
    smart00225
    Location:31 → 115
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:20 → 115
    BTB; BTB/POZ domain

  15. NM_169822.2 → NP_732350.1  fruitless, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732350.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN81
    Related
    FBpp0083067
    Conserved Domains (3) summary
    smart00225
    Location:31 → 115
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00597
    Location:559 → 634
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam00651
    Location:20 → 115
    BTB; BTB/POZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG97 A0A0B4KG97
E1JIP5 E1JIP5
Q8IN81.1 Q8IN81

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools