BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  81 LCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 159
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 45553417 160 LQVRG 164
Cdd:cd18315  81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  81 LCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 159
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 45553417 160 LQVRG 164
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417     83 DVTLACEGETVKAHQTILSACSPYFETIFLQNQ--HPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESL 160
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 45553417    161 QVRGLTD 167
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  81 LCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 159
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 45553417 160 LQVRG 164
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417     83 DVTLACEGETVKAHQTILSACSPYFETIFLQNQ--HPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESL 160
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 45553417    161 QVRGLTD 167
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  64 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMYKG 141
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNlsEKENSEVEFQCIDETALQAIVEYAYTG 80

                        90       100
                ....*....|....*....|..
gi 45553417 142 EVNVGQSSLPMFLKTAESLQVR 163
Cdd:cd18257  81 TVFISQATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  76 LQRE----ALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHP---IIYLKDVRYSEMRSLLDFMYKGEVNVGQS 148
Cdd:cd18293   6 LHRQqnsgVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGqkvVLELQGLKAHTLLKLVDFLYTSELEVSSE 85

                        90
                ....*....|....*..
gi 45553417 149 SLPMFLKTAESLQVRGL 165
Cdd:cd18293  86 EAQDVLAAARRLQISEL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  62 NNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMY 139
Cdd:cd18242   2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEmsEKGKSEVELQGLTASTMEILLDFVY 81

                        90       100
                ....*....|....*....|....*
gi 45553417 140 KGEVNVGQSSLPMFLKTAESLQVRG 164
Cdd:cd18242  82 TETVHVTVENVQELLPAACLLQLKG 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  64 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMYKG 141
Cdd:cd18237   4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNmtESKSSEVELKDAEPDIIELLVEFAYTA 83

                        90       100
                ....*....|....*....|.
gi 45553417 142 EVNVGQSSLPMFLKTAESLQV 162
Cdd:cd18237  84 RISVNSNNVQSLLDAANQYQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  71 VLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHPIIyLKDVRYSEMRSLLDFMYKGEVNVGQ 147
Cdd:cd18235  11 VMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFtgdLSESRANRVT-LQDVDGKALLLLIDYVYTAEIQVTE 89

                        90       100
                ....*....|....*....|
gi 45553417 148 SSLPMFLKTAESLQvrgLTD 167
Cdd:cd18235  90 ENVQVLLPAANLLQ---LTD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  65 PTNLTGVLTSLLQREALCDVTLACEGETVK----AHQTILSACSPYFETIFLQNQ---HPHPIIYLKDVRYSEMRSLLDF 137
Cdd:cd18211   9 PSNLLNEMHKLRLLGHLCDVTVQVEHQGSKeefsAHKAVLAASSKYFKEVFLNEKisdGKNTNVMLNEIYTADFASFLEF 88

                        90       100       110
                ....*....|....*....|....*....|
gi 45553417 138 MYKGEVNVGQSSLPMFLKTAESLQVRGLTD 167
Cdd:cd18211  89 VYTAKVEVEEDRVQRMLEIAEKLKCLDLSE 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  71 VLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFL--QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQS 148
Cdd:cd18338  11 VMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTgeMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEE 90

                        90
                ....*....|....*
gi 45553417 149 SLPMFLKTAESLQVR 163
Cdd:cd18338  91 NVQVLLPAAGLLQLQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  58 CLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLK-DVRYSEMRSLL 135
Cdd:cd18331   1 CIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTdQLKCNLSVINLDpEINPEGFNILL 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 45553417 136 DFMYKGEVNVGQSSLPMFLKTAESLQVRGLTD 167
Cdd:cd18331  81 DFMYTSRLNLREGNIMAVMATAMYLQMEHVVD 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  64 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQ-----NQHphpIIYLKDVRYSEMRSLLDFM 138
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmresSQD---EIELKGVSAKGLKHILDFA 77

                        90       100
                ....*....|....*....|....
gi 45553417 139 YKGEVNVGQSSLPMFLKTAESLQV 162
Cdd:cd18255  78 YTSELTLDLDCIQDVLGAAVHLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  72 LTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF----LQNQHPHpiIYLKDVRYSEMRSLLDFMYKGEVNVGQ 147
Cdd:cd18246  30 MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFtnemSESRQTH--VTLHDIDPQALEQLVQYAYTAEIVVGE 107

                        90       100
                ....*....|....*....|
gi 45553417 148 SSLPMFLKTAESLQVRGLTD 167
Cdd:cd18246 108 GNVQTLLPAASLLQLNGVRD 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  68 LTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQH-----PHPIIyLKDVRYSEMRSLLDFMYKGE 142
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPkddgsTYKIE-LEGISVEVMEEILDYIYTGQ 79

                        90       100
                ....*....|....*....|....*
gi 45553417 143 VNVGQSSLPMFLKTAESLQVRGLTD 167
Cdd:cd18245  80 IKLSEDNIQDIVQAADLLLMTDLKD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  71 VLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHpIIYLKDVRYSEMRSLLDFMYKGEVNVGQ 147
Cdd:cd18240   7 VFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFtngWNETEKK-VYKIPGVSPEMMELIIEYAYTRTVPITA 85

                        90
                ....*....|....*...
gi 45553417 148 SSLPMFLKTAESLQVRGL 165
Cdd:cd18240  86 ENVEELLPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  64 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHpIIYLKDVRYSEMRSLLDFMYK 140
Cdd:cd18265   6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFgghLKESRQA-VVEIQKVSAAAMEVLLDYMYG 84

                        90       100
                ....*....|....*....|....*..
gi 45553417 141 GEVNVGQSSLPMFLKTAESLQVRGLTD 167
Cdd:cd18265  85 GGLRIQEDNVESVLEASDLLQVSKLRE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  64 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHphpIIYLKDVRYSEMRSLLDFMYKGEV 143
Cdd:cd18206   5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKD---VVHLDISNAAGLGQVLEFMYTAKL 81

                        90       100
                ....*....|....*....|
gi 45553417 144 NVGQSSLPMFLKTAESLQVR 163
Cdd:cd18206  82 SLSPENVDDVLAVATFLQMQ 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  63 NHPTNLTGVLTSLLQREALCDVTLACEGETVKA--------HQTILSACSPYFETIFL--QNQHPHPIIYLKDVRYSEMR 132
Cdd:cd18273   8 AHARALLAQLKSFYDARLLTDVTIEVNGPGSGPgsgrlfpcNRNVLAAASPYFKSMFTggLYESKQETVTIHDVDSESMA 87

                        90       100       110
                ....*....|....*....|....*....|
gi 45553417 133 SLLDFMYKGEVNVGQSSLPMFLKTAESLQV 162
Cdd:cd18273  88 LIIDYCYTGRVTLSEANVQRLYAAANMLQL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  77 QREALCDVTLACEGETVKAHQTILSACSPYFETiFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNV-GQSSLPMFLK 155
Cdd:cd18221  14 ELDQFTDITLIVDGHQFKAHKAVLAACSQFFYK-FFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVqGEEEANDVWK 92

                        90       100
                ....*....|....*....|.
gi 45553417 156 TAESLQ----VRGLTDNNNLN 172
Cdd:cd18221  93 AAEYLQmqeaIKALEFRNKES 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  66 TNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETI---FLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGE 142
Cdd:cd18330   3 TKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALlihYIQDSGRHSTASLDIVTSEAFSIILDFLYSGK 82

                        90       100
                ....*....|....*....|
gi 45553417 143 VNVGQSSLPMFLKTAESLQV 162
Cdd:cd18330  83 LDLCSENVIEVMSAASYLQM 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  64 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLqNQHPHP---IIYLKDVRYSEMRSLLDFMYK 140
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFC-NDHRESremLVEINGILAEAMDCFLQYVYT 79

                        90       100
                ....*....|....*....|....*..
gi 45553417 141 GEVNVGQSSLPMFLKTAESLQVRGLTD 167
Cdd:cd18253  80 GKVKITTENVQYLFETSSLFQISPLRD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  64 HPTNLTGVLTSLLQ-------REALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYLKDVRysEMRSLLD 136
Cdd:cd18208   1 HSINLHNFSNSVLEtlneqrnRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQ--SVQKLID 78

                        90       100       110
                ....*....|....*....|....*....|.
gi 45553417 137 FMYKGEVNVGQSSLPMFLKTAESLQVRGLTD 167
Cdd:cd18208  79 FMYSGVLRVSQSEALQILTAASILQIKTVID 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  76 LQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHpIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLK 155
Cdd:cd18226  17 QKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTD-AVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLE 95

                ....*..
gi 45553417 156 TAESLQV 162
Cdd:cd18226  96 AAKFLDI 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  60 RWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF------LQNQHphpiIYLKDVRYSEMRS 133
Cdd:cd18251   2 RSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFagglreMQQTE----VLIHGVSYNAMCK 77

                        90       100
                ....*....|....*....|....*....
gi 45553417 134 LLDFMYKGEVNVGQSSLPMFLKTAESLQV 162
Cdd:cd18251  78 ILDFIYTSELELSLDNVQETLTAACQLQI 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  63 NHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQ-HPHPIIYLKD-VRYSEMRSLLDFMYK 140
Cdd:cd18198   7 DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAvVDQQNVYEIDfVSPEALTALLEFAYT 86

                        90       100
                ....*....|....*....|..
gi 45553417 141 GEVNVGQSSLPMFLKTAESLQV 162
Cdd:cd18198  87 ATLTVSTANVGDILSAARLLEI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  82 CDVTLACEGETVKAHQTILSACSPYFETIFlQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEV--NVGQSSLPMFlkTAES 159
Cdd:cd18290  28 CDVSVVVKGHAFKAHRAVLAASSSYFRDLF-NSSRSAVVELPAAVQPQSFQQILSFCYTGRLsmNVGDQFLLMY--TAGF 104

                ....*...
gi 45553417 160 LQVRGLTD 167
Cdd:cd18290 105 LQIQEIME 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  59 LRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYLKD-VRYSEMRSLLDF 137
Cdd:cd18224   4 LHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDfITPANFEKVLSF 83

                        90       100
                ....*....|....*....|....*...
gi 45553417 138 MYKGEVNVGQSSLPMFLKTAESLQVRGL 165
Cdd:cd18224  84 IYTSELFTDLINVGVIYEVAEKLGMEDL 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  81 LCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYL-KDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 159
Cdd:cd18955   1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                ....*...
gi 45553417 160 LQVRGLTD 167
Cdd:cd18955  81 LGVHNIEK 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  82 CDVTLACEGETVKAHQTILSACSPYFETIFLQNqhpHPIIYLKDVRYSE-MRSLLDFMYKGEVNVGQSSLPMFLKTAESL 160
Cdd:cd18229  19 CDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLG---HSEIEVPPVVPAQtVRQLVEFMYSGSLVVAQSEALQILTAASIL 95

                ....*..
gi 45553417 161 QVRGLTD 167
Cdd:cd18229  96 QIKTVID 102

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45553417  75 LLQREALCDVTLACEGETVKAHQTILSACSPYFETIFL-------QNQHPHPIIYLKDvryseMRSLLDFMYKGEVNVGQ 147
Cdd:cd18263   7 LWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTsgmkestQSVVQLPTIPAKD-----LRLLISFAYSGILHLSW 81

                        90
                ....*....|....*...
gi 45553417 148 SSLPMFLKTAESLQVRGL 165
Cdd:cd18263  82 ENLFEATCTALQLQISGA 99