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Ns1 Nucleostemin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42060, updated on 2-Nov-2024

Summary

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Official Symbol
Ns1provided by FlyBase
Official Full Name
Nucleostemin 1provided by FlyBase
Primary source
FLYBASE:FBgn0038473
Locus tag
Dmel_CG3983
See related
AllianceGenome:FB:FBgn0038473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3983; Dmel\CG3983; dmNS1; ns1; NS1
Summary
Enables ATP hydrolysis activity and GTPase activity. Involved in regulation of cell population proliferation; regulation of growth; and ribosomal large subunit biogenesis. Located in granular component. Is expressed in spermatozoon. Orthologous to several human genes including GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Ns1 in Genome Data Viewer
Location:
89E11-89E11; 3-59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17070523..17072675, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12896245..12898397, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Protein associated with topo II related - 1 Neighboring gene Daughters against dpp Neighboring gene mitochondrial ribosomal protein S11 Neighboring gene Keap1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RpL22e, but not RpL22e-like-PA, is SUMOylated and localizes to the nucleoplasm of Drosophila meiotic spermatocytes. Kearse MG, et al. Nucleus, 2013 May-Jun. PMID 23778934, Free PMC Article
  2. Knockdown of the Drosophila GTPase nucleostemin 1 impairs large ribosomal subunit biogenesis, cell growth, and midgut precursor cell maintenance. Rosby R, et al. Mol Biol Cell, 2009 Oct. PMID 19710426, Free PMC Article
  3. Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila. Hartl TA, et al. Genetics, 2013 May. PMID 23436180, Free PMC Article
  4. Independent active and thermodynamic processes govern the nucleolus assembly in vivo. Falahati H, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28115706, Free PMC Article
  5. Loss of Drosophila nucleostemin 2 (NS2) blocks nucleolar release of the 60S subunit leading to ribosome stress. Wang Y, et al. Chromosoma, 2017 Jun. PMID 27150106

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in granular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleostemin 1
Names
CG3983-PA
Ns1-PA
nucleostemin ortholog 1
nucleostemin1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17070523..17072675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169742.3 → NP_732199.2  nucleostemin 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732199.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V308, B6IDZ0, Q8MT06, Q9VEN7
    Related
    FBpp0082867
    Conserved Domains (5) summary
    cd00882
    Location:271 → 400
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
    cd04178
    Location:152 → 322
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:121 → 443
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08701
    Location:17 → 88
    GN3L_Grn1; GNL3L/Grn1 putative GTPase
    cl21568
    Location:59 → 150
    SurA_N_3; SurA N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MT06.2 Q8MT06

Gene LinkOut

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