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Cad87A Cadherin 87A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41441, updated on 2-Nov-2024

Summary

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Official Symbol
Cad87Aprovided by FlyBase
Official Full Name
Cadherin 87Aprovided by FlyBase
Primary source
FLYBASE:FBgn0037963
Locus tag
Dmel_CG6977
See related
AllianceGenome:FB:FBgn0037963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cad87; CG6977; CT21611; DCad87A; Dmel\CG6977
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules and cell-cell adhesion mediated by cadherin. Predicted to be active in plasma membrane. Is expressed in adult head; main body follicle cell; and oocyte. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; autosomal recessive nonsyndromic deafness; autosomal recessive nonsyndromic deafness 12; cone-rod dystrophy 15; and pituitary adenoma 5. Orthologous to human CDH23 (cadherin related 23) and CDHR1 (cadherin related family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Cad87A in Genome Data Viewer
Location:
87A1-87A2; 3-51 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11893512..11949129, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7719234..7774851, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene methuselah-like 5 Neighboring gene Dynein axonemal light intermediate chain 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 70 Aa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New properties of Drosophila scs and scs' insulators. Kyrchanova O, et al. PLoS One, 2013. PMID 23638134, Free PMC Article
  2. Cadherins in embryonic and neural morphogenesis. Tepass U, et al. Nat Rev Mol Cell Biol, 2000 Nov. PMID 11253370
  3. Expression patterns of cadherin genes in Drosophila oogenesis. Zartman JJ, et al. Gene Expr Patterns, 2009 Jan. PMID 18817893, Free PMC Article
  4. Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis. Harris KP, et al. J Cell Biol, 2008 Dec 15. PMID 19064670, Free PMC Article
  5. The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells. Skwarek LC, et al. Development, 2014 Aug. PMID 25053431, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
cadherin 87A
Names
CG6977-PA
Cad87A-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11893512..11949129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169440.3 → NP_731649.2  cadherin 87A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731649.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MQL5, Q9VGG5
    Related
    FBpp0081987
    Conserved Domains (3) summary
    cd11304
    Location:778 → 873
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:692 → 772
    CA; Cadherin repeats
    cl09101
    Location:627 → 667
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGG5.4 Q9VGG5

Gene LinkOut

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