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nedd1 NEDD1 gamma-tubulin ring complex targeting factor [ Danio rerio (zebrafish) ]

Gene ID: 406827, updated on 18-Sep-2024

Summary

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Official Symbol
nedd1provided by ZNC
Official Full Name
NEDD1 gamma-tubulin ring complex targeting factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2906
See related
Ensembl:ENSDARG00000013472 AllianceGenome:ZFIN:ZDB-GENE-040426-2906
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb78g03; zgc:63491; wu:fb78g03
Summary
Acts upstream of or within protein localization to centrosome. Located in centrosome and cytoplasm. Is expressed in central nervous system; neural tube; optic cup; and solid lens vesicle. Orthologous to human NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See nedd1 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (19541021..19556974)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (19443070..19459023)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene glutaminase like Neighboring gene SH3-domain GRB2-like 3b Neighboring gene si:ch211-59o9.10 Neighboring gene LYR motif containing 5b Neighboring gene synaptonemal complex protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An essential function for the centrosomal protein NEDD1 in zebrafish development. Manning JA, et al. Cell Death Differ, 2010 Aug. PMID 20150915
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein NEDD1
Names
neural precursor cell expressed, developmentally down-regulated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213506.1 → NP_998671.1  protein NEDD1

    See identical proteins and their annotated locations for NP_998671.1

    Status: PROVISIONAL

    Source sequence(s)
    BC058053
    UniProtKB/TrEMBL
    Q6PEI2
    Conserved Domains (3) summary
    COG2319
    Location:14 → 301
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:34 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:38 → 77
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    19541021..19556974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163004.5 → XP_005163061.1  protein NEDD1 isoform X1

    See identical proteins and their annotated locations for XP_005163061.1

    UniProtKB/TrEMBL
    A0A8M2BA03, F1QAL1
    Related
    ENSDARP00000016280.8, ENSDART00000027740.8
    Conserved Domains (3) summary
    COG2319
    Location:14 → 301
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:34 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:38 → 77
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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