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AGO3 argonaute RISC catalytic component 3 [ Bos taurus (domestic cattle) ]

Gene ID: 406231, updated on 10-Oct-2024

Summary

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Gene symbol
AGO3
Gene description
argonaute RISC catalytic component 3
See related
BGD:BT25515; Ensembl:ENSBTAG00000018324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
EIF2C3
Orthologs
human mouse all
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Genomic context

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See AGO3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (109741897..109873016, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene magnesium transporter 1-like pseudogene Neighboring gene tektin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA aspartic acid (anticodon AUC) Neighboring gene argonaute RISC component 1 Neighboring gene argonaute RISC component 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein argonaute-3
Names
argonaute3
eIF-2C 3
eIF2C 3
eukaryotic translation initiation factor 2C, 3
NP_001001133.2
XP_024840986.1
XP_024841008.2
XP_024841013.1
XP_059737958.1
XP_059737962.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001133.2 → NP_001001133.2  protein argonaute-3

    Status: VALIDATED

    Source sequence(s)
    NKLS02000003
    UniProtKB/TrEMBL
    A0A3Q1M249, A0A3Q1NME7
    Related
    ENSBTAP00000063841.1, ENSBTAT00000073962.1
    Conserved Domains (4) summary
    cd02846
    Location:228 → 348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393 → 818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177 → 227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:73 → 167
    ArgoN; N-terminal domain of argonaute

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    109741897..109873016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024985218.2 → XP_024840986.1  protein argonaute-3 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1NME7
    Conserved Domains (4) summary
    cd02846
    Location:228 → 348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393 → 830
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177 → 227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:73 → 167
    ArgoN; N-terminal domain of argonaute

  2. XM_059881975.1 → XP_059737958.1  protein argonaute-3 isoform X2

  3. XM_059881979.1 → XP_059737962.1  protein argonaute-3 isoform X3

  4. XM_024985245.2 → XP_024841013.1  protein argonaute-3 isoform X5

    UniProtKB/TrEMBL
    A0A3Q1MCZ3
    Conserved Domains (3) summary
    cd02846
    Location:77 → 197
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:242 → 679
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:26 → 76
    ArgoL1; Argonaute linker 1 domain

  5. XM_024985240.2 → XP_024841008.2  protein argonaute-3 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6T5B7.2 GenPept UniProtKB/Swiss-Prot:Q6T5B7

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