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lost lost [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40559, updated on 18-Sep-2024

Summary

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Official Symbol
lostprovided by FlyBase
Official Full Name
lostprovided by FlyBase
Primary source
FLYBASE:FBgn0263594
Locus tag
Dmel_CG14648
See related
AllianceGenome:FB:FBgn0263594
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.126; CG14648; Dmel\CG14648; growl; Growl; Lost; nev; nvd
Summary
Involved in pole cell development and pole plasm oskar mRNA localization. Located in cytoplasm. Part of ribonucleoprotein complex. Is expressed in adult head; adult heart; ovary; and primordial germ cell. Orthologous to human MTHFSD (methenyltetrahydrofolate synthetase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See lost in Genome Data Viewer
Location:
82A6-82A6; 3-47.1 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4403076..4407182)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (228798..232904)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45187 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spargel Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ouija board: A transcription factor evolved for only one target in steroid hormone biosynthesis in the fruit fly Drosophila melanogaster. Niwa YS, et al. Transcription, 2016 Oct 19. PMID 27434771, Free PMC Article
  2. Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26. Salerno-Kochan A, et al. Life Sci Alliance, 2022 Aug. PMID 35512835, Free PMC Article
  3. A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin. Sinsimer KS, et al. Development, 2011 Aug. PMID 21752933, Free PMC Article
  4. The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth. Alizzi RA, et al. PLoS Genet, 2020 Dec. PMID 33370772, Free PMC Article
  5. RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor. Ryu YH, et al. Dev Biol, 2015 Nov 15. PMID 26433064, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in pole cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pole plasm mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm oskar mRNA localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lost
Names
CG14648-PA
growl
lost boys
lost-PA
neverland

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4403076..4407182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141209.3 → NP_649466.1  lost [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649466.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGE9, Q9VN21
    Related
    FBpp0078561
    Conserved Domains (2) summary
    cd12270
    Location:384 → 455
    RRM_MTHFSD; RNA recognition motif in vertebrate methenyltetrahydrofolate synthetase domain-containing proteins
    cl00360
    Location:67 → 238
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGE9 Q8IGE9
Q9VN21 Q9VN21

Gene LinkOut

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