2E5J


Conserved Protein Domain Family
RRM_MTHFSD
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cd12270: RRM_MTHFSD (this model, PSSM-Id:240716 is obsolete and has been replaced by 409713)
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RNA recognition motif in vertebrate methenyltetrahydrofolate synthetase domain-containing proteins
This subfamily corresponds to methenyltetrahydrofolate synthetase domain (MTHFSD), a putative RNA-binding protein found in various vertebrate species. It contains an N-terminal 5-formyltetrahydrofolate cyclo-ligase domain and a C-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). The biological role of MTHFSD remains unclear.
Links
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Statistics
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PSSM-Id: 240716
Aligned: 10 rows
Threshold Bit Score: 105.499
Created: 13-Sep-2011
Updated: 1-Feb-2013
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2E5J_A        21 DVYVGNLPrDARVSDLKRALRElGSVPLRLTWQGpRRRAFLHYPD-----------SAAAQQAVSCLQGLRLGTDTLRVA 89  human
Q52L34       312 TVYIGDIPsTTRVSELKSMLRErGAAPLRLTWQGaQHRAFLDYRD-----------VAQAKQALSSLEGISINGISLLVE 380 African clawed ...
XP_414185    316 TVYVGNIPpNLRVSELKCALREfRAAPLRVSWQGaQHRAFLDYKD-----------KATAESAVSSLKGLSLGGNTLRVE 384 chicken
NP_001038564 307 TVYLSDIPpALRVSELKGLLREqEVVPLQIRWQGaKRKAFLLYAD-----------FTGAERATAILQKLFINGHTIQAK 375 zebrafish
BAH72686      47 VLKVGNIAnNVRVRDLKAALMErGVKPLHITWRGpRGFAYLRYSNs---------sDLDKDDVMGSLQNVRIKPNGIETA 117 pea aphid
EFN60600     338 SLKLSNISsGVRVRDLKNALLErGIKPSEITWQGyRGICYLHFSKlrnen-alpdqPIQVDSIVANLQQLRIGEFMNNEE 416 Camponotus flor...
EHJ78566     275 TVKISNISpNTRVRDIKSALFErGVKPHVMIWKGfRGFCYLHFFKpgpqkgegdipAANMDSVLAALAQMSVGGSGGAPD 354 monarch butterfly
NP_649466    384 CIKLTNLSrDIRVKDLKSELRKrECTPMSISWKGhFGKCFLHFGNrkgv----pstQDDMDKVLKSLNDLSLTITTGGET 459 fruit fly
XP_001846943 346 CIRVSNINrSMRIKELKQVLRVrDLNPMFIKWNGfHGKCYLHFPKkp--------dMNDDDAGAELLKQLENLTVTVTPR 417 southern house ...
XP_002610203 341 TLWVGKLSgSLRVSDFKSHLHEsNINPSRVIWKGnRGFAFLLFKE-----------AGAVDEAAKKLQDLDFSGKKVTVE 409 Florida lancelet

2E5J_A        90 LAR 92  human
Q52L34       381 LAR 383 African clawed frog
XP_414185    385 LAK 387 chicken
NP_001038564 376 CVS 378 zebrafish
BAH72686     118 QTQ 120 pea aphid
EFN60600     417 GFI 419 Camponotus floridanus
EHJ78566     355 ERE 357 monarch butterfly
NP_649466    460 APA 462 fruit fly
XP_001846943 418 EKD 420 southern house mosquito
XP_002610203 410 RAK 412 Florida lancelet
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