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OCLN occludin [ Canis lupus familiaris (dog) ]

Gene ID: 403844, updated on 17-Aug-2024

Summary

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Official Symbol
OCLNprovided by VGNC
Official Full Name
occludinprovided by VGNC
Primary source
VGNC:VGNC:44094
See related
Ensembl:ENSCAFG00845012752
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See OCLN in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (55004936..55058838)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (51466637..51511781)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (53733721..53779092)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (52076201..52121488)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (52843313..52888432)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119870032 Neighboring gene uncharacterized LOC119870033 Neighboring gene MICOS complex subunit MIC27-like Neighboring gene general transcription factor IIH subunit 2 Neighboring gene uncharacterized LOC119870283 Neighboring gene survival motor neuron

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Angulin-1 seals tricellular contacts independently of tricellulin and claudins.
    Title: Angulin-1 seals tricellular contacts independently of tricellulin and claudins.
  2. In the present study, organspecific expression of the tight junction proteins, claudin, occludin, junction adhesion molecule A and zona occludens 1 was examined in the canine duodenum, lung, liver and kidney.
    Title: Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
  3. Occludin and ZO-1 expression remained unchanged between atopic and clinically normal dogs.
    Title: Tight junction proteins in the canine epidermis: a pilot study on their distribution in normal and in high IgE-producing canines.
  4. EhCP112 and EhADH112 co-localize with occludin and claudin-1 at tight junctions.
    Title: The EhCPADH112 complex of Entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage.
  5. occludin has a role in centrosome separation and mitosis
    Title: Occludin localizes to centrosomes and modifies mitotic entry.
  6. The 41- and 48-kDa C-terminal occludin fragments formed during cholesterol depletion result from the action of a GM6001-sensitive metalloproteinase(s) at some point in the path leading to release of the membrane particles.
    Title: Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments.
  7. Elevated expression of p110 CUX1 causes loss of E-cadherin and Occludin from cell-cell junctions
    Title: p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin.
  8. a unique motif in the occludin sequence that is involved in the regulation of ZO-1 binding by reversible phosphorylation of specific Tyr residues.
    Title: Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions.
  9. Knockdown of occludin caused mislocalization of tricellulin to bTJs, implying that occludin supports tricellular localization of tricellulin by excluding tricellulin from bicellular tight junctions.
    Title: Loss of occludin affects tricellular localization of tricellulin.
  10. Removing Cholesterol from the plasma membrane increased tyrosine and threonine phosphorylation of occludin, and transepithelial electrical resistance (TER).
    Title: Cholesterol depletion alters detergent-specific solubility profiles of selected tight junction proteins and the phosphorylation of occludin.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
occludin
NP_001003195.1
XP_038513646.1
XP_038513647.1
XP_038513648.1
XP_038513649.1
XP_038513650.1
XP_038513651.1
XP_038513652.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003195.1 → NP_001003195.1  occludin

    See identical proteins and their annotated locations for NP_001003195.1

    Status: PROVISIONAL

    Source sequence(s)
    U49221
    UniProtKB/Swiss-Prot
    Q28269
    UniProtKB/TrEMBL
    A0A8C0M4A4, A0A8I3NDV4
    Conserved Domains (2) summary
    pfam01284
    Location:58 → 262
    MARVEL; Membrane-associating domain
    pfam07303
    Location:422 → 517
    Occludin_ELL; Occludin homology domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    55004936..55058838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657721.1 → XP_038513649.1  occludin isoform X1

    UniProtKB/TrEMBL
    A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
    Related
    ENSCAFP00845017787.1, ENSCAFT00845022680.1
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 262
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

  2. XM_038657718.1 → XP_038513646.1  occludin isoform X1

    UniProtKB/TrEMBL
    A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 262
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

  3. XM_038657724.1 → XP_038513652.1  occludin isoform X2

    UniProtKB/TrEMBL
    A0A8C0M4A4, A0A8I3NDV4
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 262
    MARVEL; Membrane-associating domain
    pfam07303
    Location:347 → 446
    Occludin_ELL; Occludin homology domain

  4. XM_038657719.1 → XP_038513647.1  occludin isoform X1

    UniProtKB/TrEMBL
    A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 262
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

  5. XM_038657720.1 → XP_038513648.1  occludin isoform X1

    UniProtKB/TrEMBL
    A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 262
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

  6. XM_038657722.1 → XP_038513650.1  occludin isoform X1

    UniProtKB/TrEMBL
    A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 262
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

  7. XM_038657723.1 → XP_038513651.1  occludin isoform X1

    UniProtKB/TrEMBL
    A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
    Related
    ENSCAFP00845017865.1, ENSCAFT00845022789.1
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 262
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    52076201..52121488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    52843313..52888432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    53733721..53779092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    51466637..51511781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28269.1 GenPept UniProtKB/Swiss-Prot:Q28269

Gene LinkOut

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Molecular Biology Databases
Research Materials