smarca5.S SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: smarca5.S
Official Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 S homeolog
Primary source: Xenbase:XB-GENE-866389
Locus tag: XELAEV_18009263mg
See related: EnsemblRapid:ENSXLAG00005031138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: iswi; SNF2H; smarca5
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1S

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (47808714..47832459, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (47484851..47508599, complement)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The tight coupling of ATP hydrolysis to DNA translocation suggests that DNA translocation is not energetically rate limiting for nucleosome repositioning by ISWI.
Title: Low processivity for DNA translocation by the ISWI molecular motor.
results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation
Title: ISWI is a RanGTP-dependent MAP required for chromosome segregation.
Plays a critical role for ISWI chromatin remodeling complexes in neural development, including eye differentiation, in the Xenopus laevis embryo.
Title: Neural and eye-specific defects associated with loss of the imitation switch (ISWI) chromatin remodeler in Xenopus laevis.
present the X-ray structure of Xenopus laevis ISWI SANT domain, derived from limited proteolysis of a C-terminal fragment of ISWI protein
Title: Structure of the SANT domain from the Xenopus chromatin remodeling factor ISWI.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens fiber cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleosome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 S homeolog

Names: imitation switch ISWI

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090399.1 → NP_001083868.1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 S homeolog

See identical proteins and their annotated locations for NP_001083868.1

Status: PROVISIONAL

Source sequence(s)

BC076715

UniProtKB/TrEMBL

A0A974DSD6, Q6DFM0

Related

ENSXLAP00005093638.1, ENSXLAT00005095336.1

Conserved Domains (6) summary

PLN03142
Location:2 → 1001

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

cd00046
Location:193 → 332

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd00167
Location:837 → 876

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00271
Location:475 → 590

Helicase_C; Helicase conserved C-terminal domain

pfam09110
Location:736 → 821

HAND; HAND

pfam09111
Location:891 → 1001

SLIDE; SLIDE

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

47808714..47832459 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)